KN 93
Tocris Bioscience, part of Bio-Techne | Catalog # 1278
CaM kinase II inhibitor; also K+ channel blocker (KV)
Key Product Details
Description
CaM kinase II inhibitor; also K+ channel blocker (KV)
Product Description
KN 93 is a potent, cell permeable inhibitor of CaM kinase II (IC50 = 0.37 μM). Also a direct extracellular open channel blocker of voltage-gated potassium channels (IC50 = 307 nM for KV1.5) and abolishes IKr in ventricular myocytes (IC50 = 102.6 nM) independently of CaM kinase II inhibition.Water soluble form and Negative Control also available.
Product Specifications
Molecular Weight
501.04
Formula
C26H29ClN2O4S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulphonamide
CAS Number
139298-40-1
PubChem ID
5312122
InChI Key
LLLQTDSSHZREGW-AATRIKPKSA-N
SMILES
O=S(N(CCO)C1=C(CN(C)C/C=C/C3=CC=C(Cl)C=C3)C=CC=C1)(C2=CC=C(OC)C=C2)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.1 | 100 with gentle warming |
Preparing Stock Solutions
for KN 93
The following data is based on the product molecular weight 501.04
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.00 mL | 9.98 mL | 19.96 mL |
| 5 mM | 0.40 mL | 2.00 mL | 3.99 mL |
| 10 mM | 0.20 mL | 1.00 mL | 2.00 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.40 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hegyi KN-93 inhibits IKr in mammalian cardiomyocytes. J.Mol.Cell.Cardiol. 2015 PMID: 26463508
- Rezazadeh KN-93 (2-[N-(2-Hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]-amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated J.Pharmacol.Exp.Ther. 2006 PMID: 16368898
- Sumi The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces DA content in PC12h cells. Biochem.Biophys.Res.Comm. 1991 PMID: 1662507
- Patel Calcium/calmodulin-dependent phosphorylation and activation of human Cdc25-C at the G2/M phase transition in HeLa cells. J.Biol.Chem. 1999 PMID: 10075693
Product Specific Notices for KN 93
For research use only
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