Dofetilide

Name: Dofetilide
Brand: Tocris Bioscience
SKU: 3757
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3757

(1)

Citations (17)

COA / SDS

KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)

Key Product Details

Description:	K_V11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K⁺ current (I_Kr)
Alternative Names:	Tikosyn,UK 68798
Chemical Name:	1-(4-Methanesulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino]ethane
Purity:	≥98% (HPLC)
Molecular Weight:	441.56

View Full Technical Details for Dofetilide

Technical Data
Citations / Reviews (1)

Biological Activity for Dofetilide

Dofetilide is a selective potassium channel blocker. Blocks K_V11.1 (hERG) channels; inhibits the rapid delayed-rectifier K⁺ current (I_Kr). Displays class III antiarrhythmic properties.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for Dofetilide

Dofetilide is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Dofetilide

M. Wt	441.56
Formula	C₁₉H₂₇N₃O₅S₂
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	115256-11-6
PubChem ID	71329
InChi Key	IXTMWRCNAAVVAI-UHFFFAOYSA-N
Smiles	CN(CCC2=CC=C(NS(=O)(C)=O)C=C2)CCOC1=CC=C(NS(=O)(C)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Dofetilide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	44.16	100

Preparing Stock Solutions for Dofetilide

The following data is based on the product molecular weight 441.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.26 mL	11.32 mL	22.65 mL
5 mM	0.45 mL	2.26 mL	4.53 mL
10 mM	0.23 mL	1.13 mL	2.26 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

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Reconstitution Calculator

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References for Dofetilide

References are publications that support the biological activity of the product.

Carmeliet Voltage- and time-dependent block of delayed K⁺ current in cardiac myocytes by dofet. J.Pharmacol.Exp.Ther. 1992 PMID: 1501123
Finlayson [³H]Dofetilide binding in SHSY5Y and HEK293 cells expressing a HERG-like K⁺ channel. Eur.J.Pharmacol. 2001 PMID: 11166283
Gwilt UK-68,798: a novel, potent and highly selective class III antiarrhythmic agent which blocks potassium channels in cardiac cells. J.Pharmacol.Exp.Ther. 1991 PMID: 1988662