Dofetilide is a selective potassium channel blocker. Blocks K_V11.1 (hERG) channels; inhibits the rapid delayed-rectifier K⁺ current (I_Kr). Displays class III antiarrhythmic properties.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications

Molecular Weight

441.56

Formula

C₁₉H₂₇N₃O₅S₂

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

1-(4-Methanesulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino]ethane

CAS Number

115256-11-6

PubChem ID

71329

InChI Key

IXTMWRCNAAVVAI-UHFFFAOYSA-N

SMILES

CN(CCC2=CC=C(NS(=O)(C)=O)C=C2)CCOC1=CC=C(NS(=O)(C)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	44.16	100

Preparing Stock Solutions for Dofetilide

The following data is based on the product molecular weight 441.56

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.26 mL	11.32 mL	22.65 mL
5 mM	0.45 mL	2.26 mL	4.53 mL
10 mM	0.23 mL	1.13 mL	2.26 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

Background References

References are publications that support the biological activity of the product.

Carmeliet Voltage- and time-dependent block of delayed K⁺ current in cardiac myocytes by dofet. J.Pharmacol.Exp.Ther. 1992 PMID: 1501123
Finlayson [³H]Dofetilide binding in SHSY5Y and HEK293 cells expressing a HERG-like K⁺ channel. Eur.J.Pharmacol. 2001 PMID: 11166283
Gwilt UK-68,798: a novel, potent and highly selective class III antiarrhythmic agent which blocks potassium channels in cardiac cells. J.Pharmacol.Exp.Ther. 1991 PMID: 1988662

Dofetilide

Tocris Bioscience, part of Bio-Techne | Catalog # 3757

Key Product Details

Description

Alternative Names

View all Voltage-gated Potassium Channel Blockers »

Product Description