XE 991 dihydrochloride

Name: XE 991 dihydrochloride
Brand: Tocris Bioscience
SKU: 2000
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2000

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Citations (1115)

COA / SDS

Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents

Key Product Details

Description:	Potent, selective K_V7 (KCNQ) channel blocker; blocks M-currents
Chemical Name:	10,10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	449.37

View Full Technical Details for XE 991 dihydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for XE 991 dihydrochloride

XE 991 dihydrochloride is a potent and selective blocker of K_V7 (KCNQ) voltage-gated potassium channels. Blocks K_V7.2+7.3 (KCNQ2+3) / M-currents (IC₅₀ = 0.6 - 0.98 μM) and K_V7.1 (KCNQ1) homomeric channels (IC₅₀ = 0.75 μM) but is less potent against K_V7.1/minK channels (IC₅₀ = 11.1 μM). Augments hippocampal ACh release and is a cognitive enhancer following oral administration in vivo.

Technical Data for XE 991 dihydrochloride

M. Wt	449.37
Formula	C₂₆H₂₀N₂O.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	122955-13-9
PubChem ID	45073462
InChi Key	WOGWMARIFDNZON-UHFFFAOYSA-N
Smiles	Cl.Cl.O=C1C2=C(C=CC=C2)C(CC2=CC=NC=C2)(CC2=CC=NC=C2)C2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for XE 991 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	44.94	100

Preparing Stock Solutions for XE 991 dihydrochloride

The following data is based on the product molecular weight 449.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.23 mL	11.13 mL	22.25 mL
5 mM	0.45 mL	2.23 mL	4.45 mL
10 mM	0.22 mL	1.11 mL	2.23 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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References for XE 991 dihydrochloride

References are publications that support the biological activity of the product.

Passmore KCNQ/M currents in sensory neurons: significance for pain therapy. J.Neurosci. 2003 PMID: 12904483
Zaczek Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J.Pharmacol.Exp.Ther. 1998 PMID: 9580619
Wang Molecular basis for differential sensitivity of KCNQ and I_Ks channels to the cognitive enhancer XE991. Mol.Pharmacol. 2000 PMID: 10825393
Wang KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science 1998 PMID: 9836639