XE 991 dihydrochloride
Catalog # 2000 | Tocris Bioscience a Bio-Techne Brand
Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents
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Key Product Details
Description: | Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents |
Chemical Name: | 10,10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride |
Purity: | ≥99% (HPLC) |
Molecular Weight: | 449.37 |
Citations for XE 991 dihydrochloride (34)
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Citations are publications that use Bio-Techne products. Selected citations for XE 991 dihydrochloride include:
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Pagani et al.
(2019)
How Gastrin-Releasing Peptide Opens the Spinal Gate for Itch.
Neuron.
2019;
PMID: 31103358 -
Georgilis et al.
(2018)
PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells.
Cancer Cell.
34:85
PMID: 29990503 -
Greene et al.
(2017)
XE991 and Linopirdine are state-dependent inhibitors for Kv7/KCNQ channels that favor activated single subunits.
J.Pharmacol.Exp.Ther..
362:177
PMID: 28483800 -
Lezmy
(2017)
M-current inhibition rapidly induces a unique CK2-dependent plasticity of the axon initial segment.
Proc Natl Acad Sci U S A.
114(47):E10234
PMID: 29109270 -
Salzer et al.
(2016)
Control of sensory neuron excitability by serotonin involves 5HT2C receptors and Ca2+-activated chloride channels.
Neuropharmacology.
110 (A):277
PMID: 27511837 -
Bordas et al.
(2015)
The M-current contributes to high threshold membrane potential oscillations in a cell type-specific way in the pedunculopontine nucleus of mice.
Mol Brain.
9:121
PMID: 25904846 -
Lee et al.
(2015)
N-MthD.-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity.
J Neurosci.
8:4
PMID: 25599691 -
Sobieski et al.
(2015)
Loss of Local Astrocyte Support Disrupts Action Potential Propagation and Glutamate Release Synchrony from Unmyelinated Hippocampal Axon Terminals In Vitro.
Front Behav Neurosci.
35:11105
PMID: 26245971 -
Parent et al.
(2015)
Cholinergic and ghrelinergic receptors and KCNQ channels in the medial PFC regulate the expression of palatability.
Front Syst Neurosci.
9:284
PMID: 26578914 -
Meredith et al.
(2015)
Kv1 channels and neural processing in vestibular calyx afferents.
Mol Pharmacol.
9:85
PMID: 26082693 -
Pérez-Ramírez et al.
(2015)
KV7 Channels Regulate Firing during Synaptic Integration in GABAergic Striatal Neurons.
PLoS One.
2015:472676
PMID: 26113994 -
Robbins et al.
(2013)
Effects of KCNQ2 gene truncation on M-type Kv7 potassium currents.
PLoS One.
8:e71809
PMID: 23977150 -
Ooi et al.
(2013)
Triple cysteine module within M-type K+ channels mediates reciprocal channel modulation by nitric oxide and reactive oxygen species.
Neural Plast.
33:6041
PMID: 23554485 -
Boehlen et al.
(2013)
Contribution of near-threshold currents to intrinsic oscillatory activity in rat medial entorhinal cortex layer II stellate cells.
J Neurophysiol.
109:445
PMID: 23076110 -
Rubi et al.
(2013)
Raised activity of L-type calcium channels renders neurons prone to form paroxysmal depolarization shifts.
Neuromolecular Med.
15:476
PMID: 23695859 -
Leitner et al.
(2012)
Restoration of ion channel function in deafness-causing KCNQ4 mutants by synthetic channel openers.
Br J Pharmacol.
165:2244
PMID: 21951272 -
Passmore et al.
(2012)
Functional significance of M-type potassium channels in nociceptive cutaneous sensory endings.
Front Mol Neurosci.
5:63
PMID: 22593734 -
He et al.
(2012)
Increased Kv1 channel expression may contribute to decreased sIPSC frequency following chronic inhibition of NR2B-containing NMDAR.
Neuropsychopharmacology.
37:1338
PMID: 22218089 -
Köhn et al.
(2012)
Differential effects of cystathionine-γ-lyase-dependent vasodilatory H2S in periadventitial vasoregulation of rat and mouse aortas.
J Physiol.
7:e41951
PMID: 22870268 -
Zemkova et al.
(2011)
NE causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+.
Endocrinology.
152:3842
PMID: 21828176 -
Zhang et al.
(2011)
AKAP79/150 signal complexes in G-protein modulation of neuronal ion channels.
J Neurosci.
31:7199
PMID: 21562284 -
Geier et al.
(2011)
Dynamic interplay of excitatory and inhibitory coupling modes of neuronal L-type calcium channels.
Am J Physiol Cell Physiol.
300:C937
PMID: 21228322 -
McCallum et al.
(2011)
The contribution of Kv7 channels to pregnant mouse and human myometrial contractility.
J Neurosci.
15:577
PMID: 20132415 -
Ipavec et al.
(2011)
KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus.
Pharmacol Res.
64:397
PMID: 21740972 -
Bi et al.
(2011)
Visceral hyperalgesia induced by forebrain-specific suppression of native Kv7/KCNQ/M-current in mice.
Mol Pain.
7:84
PMID: 22029713 -
Xu et al.
(2009)
MinK-dependent internalization of the IKs potassium channel.
Cardiovasc Res.
82:430
PMID: 19202166 -
Joshi et al.
(2009)
KCNQ modulators reveal a key role for KCNQ potassium channels in regulating the tone of rat pulmonary artery smooth muscle.
J Neurosci.
329:368
PMID: 19151245 -
Anderson et al.
(2009)
KCNQ currents and their contribution to resting membrane potential and the excitability of interstitial cells of Cajal from the guinea pig bladder.
J.Urol..
182:330
PMID: 19450820 -
Kim and Marcus
(2009)
Endolymphatic sodium homeostasis by extramacular epithelium of the saccule.
J Neurosci.
29:15851
PMID: 20016101 -
Kim et al.
(2009)
Regulation of ENaC-mediated sodium transport by glucocorticoids in Reissner's membrane epithelium.
Am J Physiol Cell Physiol.
296:C544
PMID: 19144862 -
Linley et al.
(2008)
Inhibition of M current in sensory neurons by exogenous proteases: a signaling pathway mediating inflammatory nociception.
Br J Pharmacol.
28:11240
PMID: 18971466 -
Wladyka et al.
(2008)
The KCNQ/M-current modulates arterial baroreceptor function at the sensory terminal in rats.
J Pharmacol Exp Ther.
586:795
PMID: 18048450 -
Strøbaek et al.
(2006)
Inhibitory gating modulation of small conductance Ca2+-activated K+ channels by the synthetic compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reduces afterhyperpolarizing current in hippocampal CA1 neurons.
J Cell Mol Med.
70:1771
PMID: 16926279 -
Yeung and Greenwood
(2005)
Electrophysiological and functional effects of the KCNQ channel blocker XE991 on murine portal vein smooth muscle cells.
J Pharmacol Exp Ther.
146:585
PMID: 16056238
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Customer Reviews for XE 991 dihydrochloride (1)
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Species: MouseAssay Type: In VitroXE 991 is a potent Kv7 channel blocker.My study focused on to finding out whether it shows the same blocking effect on Kv11.1 channels. The product worked ideally in lab coditions, produced reproducible data. Would purchase again.
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