XE 991 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 2000

Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents
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Key Product Details

Description

Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents

View all Voltage-gated Potassium Channel Blockers »

Product Description

XE 991 dihydrochloride is a potent and selective blocker of KV7 (KCNQ) voltage-gated potassium channels. Blocks KV7.2+7.3 (KCNQ2+3) / M-currents (IC50 = 0.6 - 0.98 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 0.75 μM) but is less potent against KV7.1/minK channels (IC50 = 11.1 μM). Augments hippocampal ACh release and is a cognitive enhancer following oral administration in vivo.

Product Specifications

Molecular Weight

449.37

Formula

C26H20N2O.2HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

10,10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride

CAS Number

122955-13-9

PubChem ID

45073462

InChI Key

WOGWMARIFDNZON-UHFFFAOYSA-N

SMILES

Cl.Cl.O=C1C2=C(C=CC=C2)C(CC2=CC=NC=C2)(CC2=CC=NC=C2)C2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 44.94 100

Preparing Stock Solutions for XE 991 dihydrochloride

The following data is based on the product molecular weight 449.37

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.23 mL 11.13 mL 22.25 mL
5 mM 0.45 mL 2.23 mL 4.45 mL
10 mM 0.22 mL 1.11 mL 2.23 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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Product Documents for XE 991 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for XE 991 dihydrochloride

For research use only

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