Azimilide dihydrochloride

Name: Azimilide dihydrochloride
Brand: Tocris Bioscience
SKU: 6318
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 6318

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Key Product Details

Description:	K_v11.1 (hERG) channel blocker
Chemical Name:	1-[[[5-(4-Chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione dihydrochloride
Purity:	≥97% (HPLC)
Molecular Weight:	530.88

View Full Technical Details for Azimilide dihydrochloride

Biological Activity for Azimilide dihydrochloride

Azimilide dihydrochloride is a K_v11.1 (hERG) channel blocker, blocks rapidly activating and slowly activating components of delayed rectifier K⁺ currents (IC₅₀ of 0.4 mM and 3 mM, respectively). Also inhibits Na⁺/Ca²⁺ exchanger in vitro. Shows inhibition of Na⁺ currents, L-type Ca²⁺ currents and other K⁺ currents at high concentrations.

Technical Data for Azimilide dihydrochloride

M. Wt	530.88
Formula	C₂₃H₂₈ClN₅O₃.2HCl
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	149888-94-8
PubChem ID	6435819
InChi Key	HHPSICLSNHCSNZ-DSHYBBOZSA-N
Smiles	CN1CCN(CC1)CCCCN2C(CN(C2=O)/N=C/C3=CC=C(C4=CC=C(C=C4)Cl)O3)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Azimilide dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	0.53	1

Preparing Stock Solutions for Azimilide dihydrochloride

The following data is based on the product molecular weight 530.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.01 mM	188.37 mL	941.83 mL	1,883.66 mL
0.05 mM	37.67 mL	188.37 mL	376.73 mL
0.1 mM	18.84 mL	94.18 mL	188.37 mL
0.5 mM	3.77 mL	18.84 mL	37.67 mL

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Reconstitution Calculator

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References for Azimilide dihydrochloride

References are publications that support the biological activity of the product.

Watanabe and Kimura Inhibitory Effect of Azimilide on Na⁺/Ca²⁺ Exchange Current in Guinae-Pig Cardiac Myocytes. J.Pharmacol.Sci. 2010 PMID: 20710119
Busch Blockade of HERG channels by the class III antiarrhythmic Azimilide: mode of action. Br.J.Pharmacol. 1998 PMID: 9484850
Busch Blockade of Human IsK channels expression in Xenopus oocytes by the novel class III antiarrhythmic NE-10064. Eur.J.Pharmacol. 1995 PMID: 7828640
Fermini Use-dependent effects of the class III antiarrhythmic agent NE-10064 (azimilide) on cardiac repolarisation: block of delayed rectifier potassium and L-type calcium currents. J.Cardiovasc.Pharmacol. 1995 PMID: 7475051

Citations for Azimilide dihydrochloride

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Azimilide was used to study Kv 11.1 channel gating mechanism

Name: Anonymous

Species: Human

Assay Type: In Vitro

Azimilide was used to study Kv11.1 channel blocking properties. Kv11.1 channels were being studied to understand the voltage gating mechanism and how the activation and blocking of the channel is different than other Kv channels.

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