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16 results for "STING/TMEM173 Small Molecules and Peptides" in Products

STING/TMEM173: Small Molecules and Peptides

STING (stimulator of interferon genes) is encoded by the TMEM173 gene and is an adaptor molecule involved in the activation of innate immune responses to PAMPS (pathogen-associated molecular patterns) and DAMPS (damage-associated molecular patterns). STING specifically recognizes cytosolic DNA products derived from pathogens (e.g., cytomegalovirus, vaccinia virus, Listeria monocytogenes or dead cells (1, 2). In the STING pathway, dsDNA derived from pathogens or damaged cells serves as a ...

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Pan-polymorph STING agonist

Chemical Name: 1-[(2-Chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-1H-indole-6-carboxamide
Purity: ≥98% (HPLC)
Pan-polymorph STING agonist

Negative control for STING Degrader SP23 (Cat. No. 8053)

Chemical Name: (2E)-N1-[6-[[2,3-Dihydro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]-N4-[4-[[(5-nitro-2-furanyl)carbonyl]amino]phenyl]-2-butenediamide
Purity: ≥98% (HPLC)
Negative control for STING Degrader SP23 (Cat. No. 8053)

Selective STING Degrader (PROTAC®)

Chemical Name: (2E)-N1-[6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]-N4-[4-[[(5-nitro-2-furanyl)carbonyl]amino]phenyl]-2-butenediamide
Purity: ≥98% (HPLC)
Selective STING Degrader (PROTAC®)

Non-nucleotide STING agonist; orally bioavailable

Chemical Name: 4-(5,6-Dimethoxybenzo[b]thiophen-2-yl)-4-oxobutanoic acid
Purity: ≥98% (HPLC)
Non-nucleotide STING agonist; orally bioavailable

mSTING agonist; induces antitumor immunological responses

Chemical Name: 5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic acid
Purity: ≥98% (HPLC)
mSTING agonist; induces antitumor immunological responses

STING antagonist

Chemical Name: N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea
Purity: ≥98% (HPLC)
STING antagonist

Endogenous high affinity STING agonist

Chemical Name: 2',3'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt
Purity: ≥98% (HPLC)
Endogenous high affinity STING agonist

STING agonist, molecular glue that causes oligomerization of STING

Chemical Name: 4-((4-(2-(tert-Butyl)-5,5-dimethyl-1,3-dioxan-2-yl)benzyl)amino)-3-methoxybenzoic acid
Purity: ≥98% (HPLC)
STING agonist, molecular glue that causes oligomerization of STING

Inhibitor of STING-TRIM29 interaction; increases cellular STING levels

Chemical Name: 4-[(2R)-3,4-Dihydro-4-[(4-hydroxyphenyl)methyl]-5-[(4-methoxyphenyl)methyl]-2-(1-methylethyl)-3-oxo-1(2H)-pyrazinyl]-3-nitro-N-[[(2S)-tetrahydro-2-furanyl]methyl]benzamide
Purity: ≥98% (HPLC)
Inhibitor of STING-TRIM29 interaction; increases cellular STING levels

Induces expression of STING and STING-related genes; antiviral

Chemical Name: 3',2'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt
Purity: ≥98% (HPLC)
Induces expression of STING and STING-related genes; antiviral

STING agonist

Chemical Name: [P(R)]-5'-O-[(R)-Hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-adenosine cyclic nucleotide disodium
Purity: ≥95% (HPLC)
STING agonist

mSTING antagonist

Purity: ≥97% (HPLC)
mSTING antagonist

Endogenous STING and DDX41 agonist; activates STING-dependent signaling

Chemical Name: 3',5'-Cyclic diguanylic acid sodium salt
Purity: ≥98% (HPLC)
Endogenous STING and DDX41 agonist; activates STING-dependent signaling

Murine-selective STING agonist

Chemical Name: 9-Oxo-10(9H)-acridineacetic acid
Purity: ≥98% (HPLC)
Murine-selective STING agonist

Potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS)

Alternate Names: RU320521
Chemical Name: 3-[1-(6,7-Dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl]-1(3H)-isobenzofuranone
Purity: ≥98% (HPLC)
Potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS)

Selective inhibitor of cyclic GMP-AMP synthase (cGAS)

Chemical Name: Methyl 4-amino-6-[(3,5-difluoro-4-iodophenyl)amino]-1,3,5-triazine-2-carboxylate
Purity: ≥98% (HPLC)
Selective inhibitor of cyclic GMP-AMP synthase (cGAS)
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