H 151
Tocris Bioscience, part of Bio-Techne | Catalog # 6675
STING antagonist
Product Description
H 151 is a STING antagonist. Covalently binds STING at Cys91, blocking palmitoylation and preventing assembly of STING clusters. Decreases inflammatory cytokine production in human and mouse cells in vitro. Also blocks CMA (Cat. No. 6677) -induced increases in levels of inflammatory cytokines in mice, and alleviates systemic inflammation in a mouse model of autoinflammatory disease.Product Specifications
Molecular Weight
279.34
Formula
C17H17N3O
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea
CAS Number
941987-60-6
PubChem ID
7616033
InChI Key
UJZDIKVQFMCLBE-UHFFFAOYSA-N
SMILES
CCC1=CC=C(C=C1)NC(NC2=CNC3=CC=CC=C23)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.93 | 100 | |
| Ethanol | 13.97 | 50 |
Preparing Stock Solutions
for H 151
The following data is based on the product molecular weight 279.34
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.58 mL | 17.90 mL | 35.80 mL |
| 5 mM | 0.72 mL | 3.58 mL | 7.16 mL |
| 10 mM | 0.36 mL | 1.79 mL | 3.58 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.72 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Haag Targeting STING with covalent small-molecule inhibitors. Nature 2018 PMID: 29973723
Product Specific Notices for H 151
For research use only
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