H 151

Name: H 151
Brand: Tocris Bioscience
SKU: 6675

Tocris Bioscience, part of Bio-Techne | Catalog # 6675

Citations (14)

COA / SDS

STING antagonist

Key Product Details

Description:	STING antagonist
Chemical Name:	N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea
Purity:	≥98% (HPLC)
Molecular Weight:	279.34

View Full Technical Details for H 151

Technical Data
Citations

Biological Activity for H 151

H 151 is a STING antagonist. Covalently binds STING at Cys91, blocking palmitoylation and preventing assembly of STING clusters. Decreases inflammatory cytokine production in human and mouse cells in vitro. Also blocks CMA (Cat. No. 6677) -induced increases in levels of inflammatory cytokines in mice, and alleviates systemic inflammation in a mouse model of autoinflammatory disease.

Compound Libraries for H 151

H 151 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for H 151

M. Wt	279.34
Formula	C₁₇H₁₇N₃O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	941987-60-6
PubChem ID	7616033
InChi Key	UJZDIKVQFMCLBE-UHFFFAOYSA-N
Smiles	CCC1=CC=C(C=C1)NC(NC2=CNC3=CC=CC=C23)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for H 151

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	27.93	100
	ethanol	13.97	50

Preparing Stock Solutions for H 151

The following data is based on the product molecular weight 279.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.58 mL	17.90 mL	35.80 mL
5 mM	0.72 mL	3.58 mL	7.16 mL
10 mM	0.36 mL	1.79 mL	3.58 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

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References for H 151

References are publications that support the biological activity of the product.

Haag Targeting STING with covalent small-molecule inhibitors. Nature 2018 PMID: 29973723