CMA
Tocris Bioscience, part of Bio-Techne | Catalog # 6677
Murine-selective STING agonist
Key Product Details
Description
Murine-selective STING agonist
Product Description
CMA is a STING agonist; murine-selective (Kd = 3.5 μM). Triggers type I IFN response in murine macrophages, with no effect on human STING signaling.Product Specifications
Molecular Weight
253.25
Formula
C15H11NO3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
9-Oxo-10(9H)-acridineacetic acid
CAS Number
38609-97-1
PubChem ID
38072
InChI Key
UOMKBIIXHQIERR-UHFFFAOYSA-N
SMILES
OC(CN1C2=CC=CC=C2C(C3=C1C=CC=C3)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.32 | 100 |
Preparing Stock Solutions
for CMA
The following data is based on the product molecular weight 253.25
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.95 mL | 19.74 mL | 39.49 mL |
| 5 mM | 0.79 mL | 3.95 mL | 7.90 mL |
| 10 mM | 0.39 mL | 1.97 mL | 3.95 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.79 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Cavlar Species-specific detection of the antiviral small-molecule compound CMA by STING. EMBO J. 2013 PMID: 23604073
- Zhang Rat and human STINGs profile similarly towards anticancer/antiviral compounds. Sci. Rep. 2015 PMID: 26669264
- Haag Targeting STING with covalent small-molecule inhibitors. Nature 2018 PMID: 29973723
Product Specific Notices for CMA
For research use only
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