CMA

Name: CMA
Brand: Tocris Bioscience
SKU: 6677

Tocris Bioscience, part of Bio-Techne | Catalog # 6677

Citations (2)

COA / SDS

Murine-selective STING agonist

Key Product Details

Description:	Murine-selective STING agonist
Chemical Name:	9-Oxo-10(9H)-acridineacetic acid
Purity:	≥98% (HPLC)
Molecular Weight:	253.25

View Full Technical Details for CMA

Technical Data
Citations

Biological Activity for CMA

CMA is a STING agonist; murine-selective (K_d = 3.5 μM). Triggers type I IFN response in murine macrophages, with no effect on human STING signaling.

Compound Libraries for CMA

CMA is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for CMA

M. Wt	253.25
Formula	C₁₅H₁₁NO₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	38609-97-1
PubChem ID	38072
InChi Key	UOMKBIIXHQIERR-UHFFFAOYSA-N
Smiles	OC(CN1C2=CC=CC=C2C(C3=C1C=CC=C3)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CMA

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	25.32	100

Preparing Stock Solutions for CMA

The following data is based on the product molecular weight 253.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.95 mL	19.74 mL	39.49 mL
5 mM	0.79 mL	3.95 mL	7.90 mL
10 mM	0.39 mL	1.97 mL	3.95 mL
50 mM	0.08 mL	0.39 mL	0.79 mL

Molarity Calculator

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Reconstitution Calculator

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References for CMA

References are publications that support the biological activity of the product.

Cavlar Species-specific detection of the antiviral small-molecule compound CMA by STING. EMBO J. 2013 PMID: 23604073
Zhang Rat and human STINGs profile similarly towards anticancer/antiviral compounds. Sci. Rep. 2015 PMID: 26669264
Haag Targeting STING with covalent small-molecule inhibitors. Nature 2018 PMID: 29973723

CMA