c-Di-GMP sodium salt

Name: c-Di-GMP sodium salt
Brand: Tocris Bioscience
SKU: 5900

Tocris Bioscience, part of Bio-Techne | Catalog # 5900

COA / SDS

Endogenous STING and DDX41 agonist; activates STING-dependent signaling

Key Product Details

Description:	Endogenous STING and DDX41 agonist; activates STING-dependent signaling
Chemical Name:	3',5'-Cyclic diguanylic acid sodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	734.37

View Full Technical Details for c-Di-GMP sodium salt

Technical Data
Citations

Biological Activity for c-Di-GMP sodium salt

c-Di-GMP sodium salt is an endogenous STING and DDX41 agonist; mediates DDX41-STING interaction. Activates STING-dependent IFN-β production in mouse and human cells. Also induces an antitumor response in a lung B16-10 melanoma mouse model, when administered intravenously within YSKO5-liposomes.

This product is sold in units of 730μg, equivalent to 1μmol.

Technical Data for c-Di-GMP sodium salt

M. Wt	734.37
Formula	C₂₀H₂₂N₁₀Na₂O₁₄P₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2222132-40-1
PubChem ID	101199074
InChi Key	SVIXOIGPVFFABR-XDODWTFASA-L
Smiles	O=P(O[C@H]1[C@H]([C@H](N6C=NC7=C6N=C(NC7=O)N)O[C@@H]1CO2)O)(O[Na])OC[C@@H]3[C@H]([C@H]([C@H](N4C=NC5=C4N=C(NC5=O)N)O3)O)OP2(O[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for c-Di-GMP sodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	14.69	20

Preparing Stock Solutions for c-Di-GMP sodium salt

The following data is based on the product molecular weight 734.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	6.81 mL	34.04 mL	68.09 mL
1 mM	1.36 mL	6.81 mL	13.62 mL
2 mM	0.68 mL	3.40 mL	6.81 mL
10 mM	0.14 mL	0.68 mL	1.36 mL

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References for c-Di-GMP sodium salt

References are publications that support the biological activity of the product.

Burdette STING is a direct innate immune sensor of cyclic di-GMP. Nature 2011 PMID: 21947006
Nakamura Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma. J.Control Release 2015 PMID: 26282097
Parvatiyar The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I IF. immune response. Nat.Immunol. 2012 PMID: 23142775