ADU-S100 disodium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 7706
STING agonist
Product Description
ADU-S100 disodium salt is a STING agonist. It induces CD8+ T-cell mediated antitumor immunity in a rat esophageal adenocarcinoma model. In mouse tumor models, the compound induces tumor regression and a potent antitumor immune response. ADU-S100 disodium salt induces phosphorylation of TBK1 and IRF3 in murine bone marrow macrophages.Product Specifications
Molecular Weight
734.50
Formula
C20H22N10Na2O10P2S2
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
[P(R)]-5'-O-[(R)-Hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-adenosine cyclic nucleotide disodium
CAS Number
1638750-95-4
PubChem ID
135390762
InChI Key
GDWOOOCBNOMMTL-ITQXCAEYSA-L
SMILES
O[C@H]1[C@]2([H])[C@H](N3C4=NC=NC(N)=C4N=C3)O[C@]1([H])CO[P@@]([S-])(O[C@]5([H])[C@@](O[C@@H](N6C7=NC=NC(N)=C7N=C6)[C@@H]5O)([H])CO[P@@]([S-])(O2)=O)=O.[Na+].[Na+]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 3.67 | 5 |
Preparing Stock Solutions
for ADU-S100 disodium salt
The following data is based on the product molecular weight 734.50
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.05 mM | 27.23 mL | 136.15 mL | 272.29 mL |
| 0.25 mM | 5.45 mL | 27.23 mL | 54.46 mL |
| 0.5 mM | 2.72 mL | 13.61 mL | 27.23 mL |
| 2.5 mM | 0.54 mL | 2.72 mL | 5.45 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zaidi Intratumoral immunotherapy with STING agonist, ADU-S100, induces CD8+ T-cell mediated anti-tumor immunity in an esophageal adenocarcinoma model. Oncotarget 2021 PMID: 33659041
- Corrales Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell Rep. 2015 PMID: 25959818
Product Specific Notices for ADU-S100 disodium salt
For research use only
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