CU-76

Product Description

CU-76 is a selective cyclic GMP-AMP synthase (cGAS) inhibitor (IC₅₀ = 0.24 μM). It specifically inhibits cGAS-STING pathway and has no effect on other nucleic acid sensing pathways such as the RIG-I-MAVS or Toll-like receptor pathways. CU-76 reduces DNA-induced IFN regulatory factor 3 (IRF3) dimerization in a dose-dependent manner, and it decreases production of IFN-β in THP-1 cells stimulated with interferon-stimulatory DNA.

Solubility

Preparing Stock Solutions for CU-76

The following data is based on the product molecular weight 407.12

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.46 mL	12.28 mL	24.56 mL
5 mM	0.49 mL	2.46 mL	4.91 mL
10 mM	0.25 mL	1.23 mL	2.46 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Li Therapeutic development by targeting the cGAS-STING pathway in autoimmune disease and cancer. Front Pharmacol 2021 PMID: 34867409
• Wang Small molecule approaches to treat autoimmune and inflammatory diseases (Part II): Nucleic acid sensing antagonists and inhibitors. Bioorg.Med.Chem.Lett 2021 PMID: 33984476
• Salinas Discovery of small-molecule cyclic GMP-AMP synthase inhibitors. J.Org.Chem 2020 PMID: 31829590