DMXAA

Name: DMXAA
Brand: Tocris Bioscience
SKU: 5601

Catalog # 5601 | Tocris Bioscience a Bio-Techne Brand

Citations (2)

COA / SDS

mSTING agonist; induces antitumor immunological responses

Key Product Details

Description:	mSTING agonist; induces antitumor immunological responses
Chemical Name:	5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic acid
Purity:	≥99% (HPLC)
Molecular Weight:	282.29

View Full Technical Details for DMXAA

Technical Data
Citations (2) / Reviews

Biological Activity for DMXAA

DMXAA is a mSTING agonist; selective for mouse STING over human STING. Induces IFN-β and cytokine production from bone marrow-derived dendritic cells. Causes tumor regression following intratumoral administration in mouse tumor models. Induces an adaptive immune response to reduce systemic tumor growth and provides immunological memory against autologous tumor re-challenge. Also antiviral.

Compound Libraries for DMXAA

DMXAA is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for DMXAA

M. Wt	282.29
Formula	C₁₇H₁₄O₄
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	117570-53-3
PubChem ID	123964
InChi Key	XGOYIMQSIKSOBS-UHFFFAOYSA-N
Smiles	O=C1C2=CC=CC(CC(O)=O)=C2OC3=C1C=CC(C)=C3C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DMXAA

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	5.65	20

Preparing Stock Solutions for DMXAA

The following data is based on the product molecular weight 282.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	17.71 mL	88.56 mL	177.12 mL
1 mM	3.54 mL	17.71 mL	35.42 mL
2 mM	1.77 mL	8.86 mL	17.71 mL
10 mM	0.35 mL	1.77 mL	3.54 mL

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References for DMXAA

References are publications that support the biological activity of the product.

Corrales Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell Rep. 2015 PMID: 25959818
Shirey The anti-tumor agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), induces IFN-β-mediated antiviral activity in vitro and in vivo. J.Leukoc.Biol. 2011 PMID: 21084628
Phillips Inhibition of DT-diaphorase (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA): implications for bioreductive drug development. Biochem.Pharmacol. 1999 PMID: 10423172

Citations for DMXAA (2)

Showing 1 - 2 of 2 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for DMXAA include:

Bryon D et al. (2021) STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic Cancer. Cell Mol Gastroenterol Hepatol. 12:41-58
PMID: 33548597
Umesh S et al. (2020) Protocols for Experimental Sjögren's Syndrome. Curr Protoc Immunol. 131:e114
PMID: 33252847

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