DMXAA
Tocris Bioscience, part of Bio-Techne | Catalog # 5601
mSTING agonist; induces antitumor immunological responses
Key Product Details
Description
mSTING agonist; induces antitumor immunological responses
Product Description
DMXAA is a mSTING agonist; selective for mouse STING over human STING. Induces IFN-β and cytokine production from bone marrow-derived dendritic cells. Causes tumor regression following intratumoral administration in mouse tumor models. Induces an adaptive immune response to reduce systemic tumor growth and provides immunological memory against autologous tumor re-challenge. Also antiviral.Product Specifications
Molecular Weight
282.29
Formula
C17H14O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic acid
CAS Number
117570-53-3
PubChem ID
123964
InChI Key
XGOYIMQSIKSOBS-UHFFFAOYSA-N
SMILES
O=C1C2=CC=CC(CC(O)=O)=C2OC3=C1C=CC(C)=C3C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.65 | 20 |
Preparing Stock Solutions
for DMXAA
The following data is based on the product molecular weight 282.29
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 17.71 mL | 88.56 mL | 177.12 mL |
| 1 mM | 3.54 mL | 17.71 mL | 35.42 mL |
| 2 mM | 1.77 mL | 8.86 mL | 17.71 mL |
| 10 mM | 0.35 mL | 1.77 mL | 3.54 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Corrales Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell Rep. 2015 PMID: 25959818
- Phillips Inhibition of DT-diaphorase (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA): implications for bioreductive drug development. Biochem.Pharmacol. 1999 PMID: 10423172
- Shirey The anti-tumor agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), induces IFN-β-mediated antiviral activity in vitro and in vivo. J.Leukoc.Biol. 2011 PMID: 21084628
Product Specific Notices for DMXAA
For research use only
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