3',2'-cGAMP sodium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 7718
Induces expression of STING and STING-related genes; antiviral
Key Product Details
Description
Induces expression of STING and STING-related genes; antiviral
Product Description
3',2'-cGAMP sodium salt is a second messenger in the antiviral immune response in Drosophila melanogaster and in bacteria. 3',2'-cGAMP is selective for Drosophila stimulator of interferon genes (dSTING); induces expression of STING and STING-related genes. After injection of drosophila C virus dsRNA into Drosophila, 3',2'-cGAMP activates STING-dependent antiviral immunity in vivo, reduces viral RNA load and increases survival. In bacteria 3',2'-cGAMP activates DNA degradation of AsCap5 and LlCap5.Product Specifications
Molecular Weight
718.38
Formula
C20H22N10Na2O13P2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3',2'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt
InChI Key
ROQCYAKTZSZNCA-DQNSRKNCSA-L
SMILES
O[C@H]1[C@@]2([C@@]([H])(O[C@@]1(COP([O-])(O[C@@]3([C@@]([H])(COP([O-])(O2)=O)O[C@]([H])([C@@H]3O)N4C5=C(N=C4)C(N=C(N)N5)=O)[H])=O)[H])N6C7=NC=NC(N)=C7N=C6)[H].[Na+].[Na+]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 7.18 | 10 |
Preparing Stock Solutions
for 3',2'-cGAMP sodium salt
The following data is based on the product molecular weight 718.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 13.92 mL | 69.60 mL | 139.20 mL |
| 0.5 mM | 2.78 mL | 13.92 mL | 27.84 mL |
| 1 mM | 1.39 mL | 6.96 mL | 13.92 mL |
| 5 mM | 0.28 mL | 1.39 mL | 2.78 mL |
Calculators
Molarity Calculator
Dilution Calculator
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Background References
References are publications that support the biological activity of the product.
- Fatma Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3',2'-cGAMP as the second messenger. Nat.Commun. 2021 PMID: 34737303
- Slavik cGAS-like receptors sense RNA and control 3',2'-cGAMP signalling in Drosophila. Nature 2021 PMID: 34261127
Product Specific Notices for 3',2'-cGAMP sodium salt
For research use only
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