C 176
Tocris Bioscience, part of Bio-Techne | Catalog # 7040
mSTING antagonist
Product Description
C 176 is a mSTING antagonist. Covalently binds Cys91 of mouse but not human STING. Blocks activation-induced palmitoylation of STING and formation of STING clusters. Reduces CMA (Cat. No. 6677) -induced increase in serum IFNs in vivo and suppresses systemic inflammation in a mouse inflammatory disease model.Product Specifications
Molecular Weight
358.09
Formula
C11H7IN2O4
Storage
Store at -20°C
Purity
≥97% (HPLC)
CAS Number
314054-00-7
PubChem ID
1103958
InChI Key
JBIKQXOZLBLMKI-UHFFFAOYSA-N
SMILES
IC1=CC=C(C=C1)NC(C2=CC=C([N+]([O-])=O)O2)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.81 | 100 |
Preparing Stock Solutions
for C 176
The following data is based on the product molecular weight 358.09
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.79 mL | 13.96 mL | 27.93 mL |
| 5 mM | 0.56 mL | 2.79 mL | 5.59 mL |
| 10 mM | 0.28 mL | 1.40 mL | 2.79 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Haag Targeting STING with covalent small-molecule inhibitors. Nature 2018 PMID: 29973723
Product Specific Notices for C 176
For research use only
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