MSA 2
Tocris Bioscience, part of Bio-Techne | Catalog # 7353
Non-nucleotide STING agonist; orally bioavailable
Key Product Details
Description
Non-nucleotide STING agonist; orally bioavailable
Product Description
MSA 2 is a non-nucleotide STING agonist (EC50 values are 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively). Exhibits antitumor activity and stimulates interferon-β secretion in tumors. Induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models. Orally bioavailable.Product Specifications
Molecular Weight
294.32
Formula
C14H14O5S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-(5,6-Dimethoxybenzo[b]thiophen-2-yl)-4-oxobutanoic acid
CAS Number
129425-81-6
PubChem ID
23035251
InChI Key
APCLRHPWFCQIMG-UHFFFAOYSA-N
SMILES
COC1=CC2=C(C=C1OC)C=C(C(CCC(O)=O)=O)S2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.43 | 100 |
Preparing Stock Solutions
for MSA 2
The following data is based on the product molecular weight 294.32
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.40 mL | 16.99 mL | 33.98 mL |
| 5 mM | 0.68 mL | 3.40 mL | 6.80 mL |
| 10 mM | 0.34 mL | 1.70 mL | 3.40 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Pan An orally available non-nucleotide STING agonist with antitumor activity. Science 2020 PMID: 32820094
Product Specific Notices for MSA 2
For research use only
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