STING agonist C53

Product Description

STING agonist C53 is an activator of human STING (EC₅₀ = 185 nM). It promotes the oligomerization and activation of human STING through a mechanism orthogonal to that of cGAMP. STING agonist C53 increases activity of STING variants in HEK293T cells (107%, 92% and 92% reporter activity against H232, R232 and HAQ, respectively). It induces phosphorylation of STING variants in human tumor cell lines and PBMCs. STING agonist C53 is active at human but not mouse STING. Orally bioavailable.

Solubility

Preparing Stock Solutions for STING agonist C53

The following data is based on the product molecular weight 490.88

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.04 mL	10.19 mL	20.37 mL
5 mM	0.41 mL	2.04 mL	4.07 mL
10 mM	0.20 mL	1.02 mL	2.04 mL
50 mM	0.04 mL	0.20 mL	0.41 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Lu Activation of STING by targeting a pocket in the transmembrane domain. Nature 2022 PMID: 35388221
• Pryde The discovery of potent small molecule activators of human STING. Eur.J.Med.Chem. 2021 PMID: 33038794