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Src: Small Molecules and Peptides

Src and other Src family protein tyrosine kinases are proto-oncogenes that play key roles in regulating cell growth and differentiation. Src family activity is regulated by tyrosine phosphorylation at two sites with opposing effects. Phosphorylation at Y419 of human Src up-regulates kinase activity, while phosphorylation at Y530 inactivates Src.

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18 results for "Src Small Molecules and Peptides" in Products

18 results for "Src Small Molecules and Peptides" in Products

Src: Small Molecules and Peptides

Src and other Src family protein tyrosine kinases are proto-oncogenes that play key roles in regulating cell growth and differentiation. Src family activity is regulated by tyrosine phosphorylation at two sites with opposing effects. Phosphorylation at Y419 of human Src up-regulates kinase activity, while phosphorylation at Y530 inactivates Src.

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Dual site Src kinase inhibitor

Chemical Name: 6,7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine
Purity: ≥98% (HPLC)
Dual site Src kinase inhibitor

Potent and selective c-Src inhibitor

Chemical Name: 1-[3-[1-([1,1'-Biphenyl]-3-ylmethyl)-1H-1,2,3-triazol-5-yl]phenyl]-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity: ≥98% (HPLC)
Potent and selective c-Src inhibitor

Potent and selective Lck and Src inhibitor; also inhibits SIK

Alternate Names: KIN112
Chemical Name: 2,6-Dimethylphenyl-N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]carbamate
Purity: ≥98% (HPLC)
Potent and selective Lck and Src inhibitor; also inhibits SIK

Potent, selective Src family kinase inhibitor

Chemical Name: 3-(4-chlorophenyl) 1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity: ≥98% (HPLC)
Potent, selective Src family kinase inhibitor

Potent, selective Src family kinase inhibitor

Chemical Name: 1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity: ≥98% (HPLC)
Potent, selective Src family kinase inhibitor

Highly potent pan-Src/Bcr-Abl inhibitor

Alternate Names: BMS-354825
Chemical Name: N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide
Purity: ≥98% (HPLC)
Highly potent pan-Src/Bcr-Abl inhibitor

Potent and selective Src tyrosine kinase family inhibitor; anticancer; antiviral; orally bioavailable

Alternate Names: AZD 0530
Chemical Name: N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine
Purity: ≥98% (HPLC)
Potent and selective Src tyrosine kinase family inhibitor; anticancer; antiviral; orally bioavailable

Src tyrosine kinase inhibitor

Chemical Name: N-(2-Chloro-5-methoxyphenyl)-6-methoxy
Purity: ≥98% (HPLC)
Src tyrosine kinase inhibitor

Dual Src-Abl inhibitor; antiproliferative

Alternate Names: SKI-606
Chemical Name: 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile
Purity: ≥98%
Dual Src-Abl inhibitor; antiproliferative

Inhibitor of Src family kinases

Chemical Name: 7-[trans-4-(4-Methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-Pyrrolo[2,3-d]pyrimidin-4-amine trihydrochloride
Purity: ≥98% (HPLC)
Inhibitor of Src family kinases

Potent Src inhibitor; also inhibits FGFR1, PDGFRβ and Wee1

Chemical Name: 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride
Purity: ≥98% (HPLC)
Potent Src inhibitor; also inhibits FGFR1, PDGFRβ and Wee1

UNC119 chaperone-cargo interaction inhibitor; disrupts Src activation

Chemical Name: Ethyl 4-((3,4-dioxo-2-((2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)amino)cyclobut-1-en-1-yl)amino)piperidine-1-carboxylate hydrochloride
Purity: ≥98% (HPLC)
UNC119 chaperone-cargo interaction inhibitor; disrupts Src activation

Src family kinase inhibitor; also inhibits c-Abl

Alternate Names: 1-NA-PP 1
Chemical Name: 1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity: ≥98% (HPLC)
Src family kinase inhibitor; also inhibits c-Abl

Potent ATP-competitive Src family kinase inhibitor; also AMPK inhibitor; cell permeable

Chemical Name: 2,3-Dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-1H-indole-5-sulfonamide
Purity: ≥95% (HPLC)
Potent ATP-competitive Src family kinase inhibitor; also AMPK inhibitor; cell permeable

Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk

Chemical Name: 3-[[2-[3-(4-Morpholinylmethyl)phenyl]thieno[3,2-b]pyridin-7-yl]amino]phenol dihydrochloride
Purity: ≥98% (HPLC)
Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk

Negative control for PP 2 (Cat. No. 1407)

Chemical Name: 1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity: ≥98% (HPLC)
Negative control for PP 2 (Cat. No. 1407)

JAK2/STAT3 signaling pathway inhibitor

Chemical Name: (1R,5R,6R,7S)-rel-4-Oxo-8-(phenylmethyl)-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid 6,7-dimethyl ester
Purity: ≥98% (HPLC)
JAK2/STAT3 signaling pathway inhibitor

High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist

Chemical Name: 7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone
Purity: ≥99% (HPLC)
High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist
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