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Src Products
Src and other Src family protein tyrosine kinases are proto-oncogenes that play key roles in regulating cell growth and differentiation. Src family activity is regulated by tyrosine phosphorylation at two sites with opposing effects. Phosphorylation at Y419 of human Src up-regulates kinase activity, while phosphorylation at Y530 inactivates Src.
33 results for "Src" in Products
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Src Products
Src and other Src family protein tyrosine kinases are proto-oncogenes that play key roles in regulating cell growth and differentiation. Src family activity is regulated by tyrosine phosphorylation at two sites with opposing effects. Phosphorylation at Y419 of human Src up-regulates kinase activity, while phosphorylation at Y530 inactivates Src.
33 results for "Src" in Products
| Clonality : | Polyclonal |
| Host : | Rabbit IgG |
| Applications : | Immunohistochemistry, Simple Western, Western Blot |
Recombinant Monoclonal Antibody.
| Clonality : | Monoclonal |
| Host : | Rabbit IgG Clone #1246F |
| Applications : | Immunocytochemistry/Immunofluorescence, Simple Western, Western Blot |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Immunohistochemistry, Simple Western, Western Blot |
Dual site Src kinase inhibitor
| Chemical Name : | 6,7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine |
| Purity : | ≥99% (HPLC) |
Potent and selective c-Src inhibitor
| Chemical Name : | 1-[3-[1-([1,1'-Biphenyl]-3-ylmethyl)-1H-1,2,3-triazol-5-yl]phenyl]-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Purity : | ≥98% (HPLC) |
| Source : | Sf 9 (baculovirus) |
| Accession # : | M11753 |
| Applications : | Bioactivity |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2a Clone #327537 |
| Applications : | Western Blot |
| Source : | Sf 9 (baculovirus) |
| Accession # : | NM_005417 |
| Applications : | Bioactivity |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2a Clone #327554 |
| Applications : | Immunohistochemistry, Western Blot |
| Assay Range : | 3.91 - 250 pg/mL |
| Applications : | ELISA |
Contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 37 different kinases and 2 related total proteins
Highly potent pan-Src/Bcr-Abl inhibitor
| Alternate Names : | BMS-354825 |
| Chemical Name : | N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide |
| Purity : | ≥98% (HPLC) |
Potent and selective Src tyrosine kinase family inhibitor; anticancer; antiviral; orally bioavailable
| Alternate Names : | AZD 0530 |
| Chemical Name : | N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine |
| Purity : | ≥98% (HPLC) |
Potent ATP-competitive Src family kinase inhibitor; also AMPK inhibitor; cell permeable
| Chemical Name : | 2,3-Dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-1H-indole-5-sulfonamide |
| Purity : | ≥98% (HPLC) |
Inhibitor of Src family kinases
| Chemical Name : | 7-[trans-4-(4-Methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-Pyrrolo[2,3-d]pyrimidin-4-amine trihydrochloride |
| Purity : | ≥98% (HPLC) |
Potent, selective Src family kinase inhibitor
| Chemical Name : | 3-(4-chlorophenyl) 1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Purity : | ≥99% (HPLC) |
Potent and selective Lck and Src inhibitor; also inhibits SIK
| Alternate Names : | KIN112 |
| Chemical Name : | 2,6-Dimethylphenyl-N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]carbamate |
| Purity : | ≥98% (HPLC) |
UNC119 chaperone-cargo interaction inhibitor; disrupts Src activation
| Chemical Name : | Ethyl 4-((3,4-dioxo-2-((2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)amino)cyclobut-1-en-1-yl)amino)piperidine-1-carboxylate hydrochloride |
| Purity : | ≥98% (HPLC) |
Potent PDGFRα and PDGFRβ inhibitor; also inhibits c-Abl, Lck, c-Src and Fyn kinases
| Chemical Name : | N-(3-Fluorophenyl)-1,4-dihydro-6,7-dimethoxyindeno[1,2-c]pyrazol-3-amine |
| Purity : | ≥98% (HPLC) |
Dual Src-Abl inhibitor; antiproliferative
| Alternate Names : | SKI-606 |
| Chemical Name : | 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile |
| Purity : | ≥99% |
Src family kinase inhibitor; also inhibits c-Abl
| Alternate Names : | 1-NA-PP 1 |
| Chemical Name : | 1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Purity : | ≥99% (HPLC) |
Potent, selective Src family kinase inhibitor
| Chemical Name : | 1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Purity : | ≥99% (HPLC) |
Src tyrosine kinase inhibitor
| Chemical Name : | N-(2-Chloro-5-methoxyphenyl)-6-methoxy |
| Purity : | ≥99% (HPLC) |
Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk
| Chemical Name : | 3-[[2-[3-(4-Morpholinylmethyl)phenyl]thieno[3,2-b]pyridin-7-yl]amino]phenol dihydrochloride |
| Purity : | ≥98% (HPLC) |
Potent Src inhibitor; also inhibits FGFR1, PDGFRβ and Wee1
| Chemical Name : | 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride |
| Purity : | ≥99% (HPLC) |
