22 results for "Phosphodiesterase Inhibitors" in Products
Phosphodiesterase Inhibitors Products
Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation.
There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8 selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, ...
PDE4 inhibitor
| Chemical Name: | 4-(3-Butoxy-4-methoxyphenyl)methyl-2-imidazolidone |
| Purity: | ≥98% (HPLC) |
PDE4 inhibitor
| Chemical Name: | 4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one |
| Purity: | ≥98% (HPLC) |
Potent and highly selective PDE5 inhibitor; orally bioavailable
| Alternate Names: | GF196960 |
| Chemical Name: | (6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione |
| Purity: | ≥98% (HPLC) |
PDE inhibitor (non-selective)
| Chemical Name: | 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione |
| Purity: | ≥98% (HPLC) |
Potent and selective PDE8B/8A inhibitor
| Chemical Name: | 5-Methyl-3-[[(2R)-4-(2-thiazolylmethyl)-2-morpholinyl]methyl]-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent PDE5 inhibitor; orally active
| Chemical Name: | 1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate |
| Purity: | ≥98% (HPLC) |
Adenosine transport inhibitor
| Chemical Name: | 2,6-bis(Diethanolamino)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine |
| Purity: | ≥98% (HPLC) |
Potent and selective PDE4 inhibitor
| Alternate Names: | RP 73401 |
| Chemical Name: | 3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamide |
| Purity: | ≥98% (HPLC) |
Adenosine deaminase inhibitor
| Chemical Name: | erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride |
| Purity: | ≥98% (HPLC) |
PDE3 inhibitor
| Alternate Names: | OCP 3689 |
| Chemical Name: | N-Cyclohexyl-N-methyl-4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyramide |
| Purity: | ≥97% (HPLC) |
Orally active PDE4 inhibitor
| Chemical Name: | (R)-5-(4-Methoxy-3-propoxyphenyl)-5-methyl-2-oxazolidinone |
| Purity: | ≥98% (HPLC) |
PDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905)
| Chemical Name: | (4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one |
| Purity: | ≥98% (HPLC) |
PDE inhibitor (non-selective)
| Alternate Names: | KC-404 |
| Chemical Name: | 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone |
| Purity: | ≥98% (HPLC) |
Potent PDE9 inhibitor; brain penetrant
| Alternate Names: | PF 9613 |
| Chemical Name: | 1,5-Dihydro-6-[(1R)-1-(3-phenoxy-1-azetidinyl)ethyl]-1-(tetrahydro-2H-pyran-4-yl)-4H-pyrazolo[3,4-d]pyrimidin-4-one |
| Purity: | ≥98% (HPLC) |
Selective PDE7 inhibitor
| Chemical Name: | N,N,2-Trimethyl-5-nitro-benzenesulfonamide |
| Purity: | ≥98% (HPLC) |
Potent and selective PDE2A inhibitor
| Chemical Name: | 4-(1-Azetidinyl)-7-methyl-5-[1-methyl-5-[5-(trifluoromethyl)-2-pyridinyl]-1H-pyrazol-4-yl]-imidazo[5,1-f][1,2,4]triazine |
| Purity: | ≥98% (HPLC) |
Potent PDE5 inhibitor; orally bioavailable
| Alternate Names: | UK 369003 |
| Chemical Name: | 5-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-3-pyridinyl]-3-ethyl-2,6-dihydro-2-(2-methoxyethyl)-7H-pyrazolo[4,3-d]pyrimidin-7-one benzenesulfonate |
| Purity: | ≥98% (HPLC) |
PDE3 inhibitor
| Chemical Name: | 1,3-Dihydro-4-methyl-5-[4-(methylthio)benzoyl]-2H-imidazol-2-one |
| Purity: | ≥98% (HPLC) |
GPR35 agonist
| Chemical Name: | 2-(2-Propyloxyphenyl)-8-azapurin-6-one |
| Purity: | ≥98% (HPLC) |
High affinity PDEδ-KRas interaction inhibitor; binds to PDEδ
| Chemical Name: | 2-[4-[(2S)-2-(2-Phenyl-1H-benzimidazol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylmethyl)-1H-benzimidazole trihydrochloride |
| Purity: | ≥98% (HPLC) |
Potent and selective PDE4B inhibitor
| Chemical Name: | 2-[4-[[2-(5-Chloro-2-thienyl)-5-ethyl-6-methyl-pyrimidin-4-yl]amino]phenyl]acetic acid |
| Purity: | ≥98% (HPLC) |
A1 and A2B antagonist. CNS stimulant
| Chemical Name: | 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione |
| Purity: | ≥98% (HPLC) |
