Enoximone
Tocris Bioscience, part of Bio-Techne | Catalog # 1693
PDE3 inhibitor
Product Description
Enoximone is an inhibitor of type III phosphodiesterase (PDE3). Increases intracellular cyclic AMP (cAMP) concentrations and enhances myocardial contractility. Also induces concentration-dependent vasodilation in vitro.Product Specifications
Molecular Weight
248.30
Formula
C12H12N2O2S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
1,3-Dihydro-4-methyl-5-[4-(methylthio)benzoyl]-2H-imidazol-2-one
CAS Number
77671-31-9
PubChem ID
53708
InChI Key
ZJKNESGOIKRXQY-UHFFFAOYSA-N
SMILES
CC(NC(N2)=O)=C2C(C1=CC=C(SC)C=C1)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.83 | 100 |
Preparing Stock Solutions
for Enoximone
The following data is based on the product molecular weight 248.30
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.03 mL | 20.14 mL | 40.27 mL |
| 5 mM | 0.81 mL | 4.03 mL | 8.05 mL |
| 10 mM | 0.40 mL | 2.01 mL | 4.03 mL |
| 50 mM | 0.08 mL | 0.40 mL | 0.81 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Pacher and Stanek Ambulatory vasodilator therapy in heart failure: systematic review of the literature and personal observational experience. Eur.J.Heart Fail. 1999 PMID: 10935673
- Vroom Effect of phosphodiesterase inhibitors on human arteries in vitro. Br.J.Anaesth. 1996 PMID: 8672353
- Jung Pharmacological effects of ATI22-107 [2-(2-{2-[2-chloro-4-(6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenoxy]-acetylamino}-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester)], a novel dual pharmacophore, o J.Pharmacol.Exp.Ther. 2005 PMID: 15550574
Product Specific Notices for Enoximone
For research use only
Loading...
Loading...