Ro 20-1724

Name: Ro 20-1724
Brand: Tocris Bioscience
SKU: 0415

Tocris Bioscience a Bio-Techne Brand

Catalog # 0415

Citations (3)

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Key Product Details

Description:	PDE4 inhibitor
Chemical Name:	4-(3-Butoxy-4-methoxyphenyl)methyl-2-imidazolidone
Purity:	≥99% (HPLC)
Molecular Weight:	278.35

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Biological Activity for Ro 20-1724

Ro 20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC₅₀ = 2.0 μM).

Compound Libraries for Ro 20-1724

Ro 20-1724 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Ro 20-1724

M. Wt	278.35
Formula	C₁₅H₂₂N₂O₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	29925-17-5
PubChem ID	5087
InChi Key	PDMUULPVBYQBBK-UHFFFAOYSA-N
Smiles	CCCCOC1=CC(CC2CNC(=O)N2)=CC=C1OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ro 20-1724

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	27.84	100
	DMSO	27.84	100

Preparing Stock Solutions for Ro 20-1724

The following data is based on the product molecular weight 278.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.59 mL	17.96 mL	35.93 mL
5 mM	0.72 mL	3.59 mL	7.19 mL
10 mM	0.36 mL	1.80 mL	3.59 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

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References for Ro 20-1724

References are publications that support the biological activity of the product.

Soderling Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. Proc.Natl.Acad.Sci.U.S.A. 1998 PMID: 9671792
Nicholson Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. TiPS 1991 PMID: 1848733
Reeves The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Biochem.J. 1987 PMID: 3036066

Citations for Ro 20-1724 (3)

Showing 1 - 3 of 3 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Ro 20-1724 include:

Winger et al. (2014) Rapid remodeling of tight junctions during paracellular diapedesis in a human model of the blood-brain barrier. J Immunol. 193:2427
PMID: 25063869
Zhong et al. (2012) Phosphodiesterase 4 inhibition impairs cocaine-induced inhibitory synaptic plasticity and conditioned place preference. Neuropsychopharmacology. 37:2377
PMID: 22713909
Peters et al. (2007) Evaluation of cellular dielectric spectroscopy, a whole-cell, label-free technology for drug discovery on Gi-coupled GPCRs. J Biomol Screen. 12:312
PMID: 17307886

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