Sildenafil citrate

Name: Sildenafil citrate
Brand: Tocris Bioscience
SKU: 3784

Tocris Bioscience, part of Bio-Techne | Catalog # 3784

Citations (6)

COA / SDS

Potent PDE5 inhibitor; orally active

Key Product Details

Description:	Potent PDE5 inhibitor; orally active
Chemical Name:	1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate
Purity:	≥98% (HPLC)
Molecular Weight:	666.7

View Full Technical Details for Sildenafil citrate

Technical Data
Citations

Biological Activity for Sildenafil citrate

Sildenafil citrate is an orally active, potent inhibitor of phosphodiesterase 5 (PDE5) (IC₅₀ = 4 nM). Enhances nitric oxide-dependent relaxation of human corpus cavernosum in vitro. Sildenafil citrate promotes mobilization of hematopoietic stem cells (HSCs) in combination with AMD 3100 (Cat. No. 3299). Reduces pulmonary pressure and edema.

Compound Libraries for Sildenafil citrate

Sildenafil citrate is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Sildenafil citrate

M. Wt	666.7
Formula	C₂₂H₃₀N₆O₄S.C₆H₈O₇
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	171599-83-0
PubChem ID	135413523
InChi Key	DEIYFTQMQPDXOT-UHFFFAOYSA-N
Smiles	O=C(O)C(O)(CC(O)=O)CC(O)=O.CN1CCN(S(C2=CC=C(OCC)C(C(NC4=C3N(C)N=C4CCC)=NC3=O)=C2)(=O)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Sildenafil citrate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	66.67	100

Preparing Stock Solutions for Sildenafil citrate

The following data is based on the product molecular weight 666.7.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.50 mL	7.50 mL	15.00 mL
5 mM	0.30 mL	1.50 mL	3.00 mL
10 mM	0.15 mL	0.75 mL	1.50 mL
50 mM	0.03 mL	0.15 mL	0.30 mL

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Reconstitution Calculator

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References for Sildenafil citrate

References are publications that support the biological activity of the product.

Smith-Berdan Viagra enables efficient, single-day hematopoietic stem cell mobilization. Stem Cell Reports. 2019 PMID: 31607567
Turko Inhibition of cyclic cGMP-binding cyclic GMP-specific phosphodiesterase (type 5) by silde. and related compounds. Mol.Pharmacol. 1999 PMID: 10385692
Ghofrani Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond. Nat.Rev.Drug Discov. 2006 PMID: 16883306
Ballard Effects of silde. on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. J.Urol. 1998 PMID: 9598563