Sildenafil citrate
Tocris Bioscience, part of Bio-Techne | Catalog # 3784
Potent PDE5 inhibitor; orally active
Key Product Details
Description
Potent PDE5 inhibitor; orally active
Product Description
Sildenafil citrate is an orally active, potent inhibitor of phosphodiesterase 5 (PDE5) (IC50 = 4 nM). Enhances nitric oxide-dependent relaxation of human corpus cavernosum in vitro. Sildenafil citrate promotes mobilization of hematopoietic stem cells (HSCs) in combination with AMD 3100 (Cat. No. 3299). Reduces pulmonary pressure and edema.Product Specifications
Molecular Weight
666.70
Formula
C22H30N6O4S.C6H8O7
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate
CAS Number
171599-83-0
PubChem ID
135413523
InChI Key
DEIYFTQMQPDXOT-UHFFFAOYSA-N
SMILES
O=C(O)C(O)(CC(O)=O)CC(O)=O.CN1CCN(S(C2=CC=C(OCC)C(C(NC4=C3N(C)N=C4CCC)=NC3=O)=C2)(=O)=O)CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 66.67 | 100 |
Preparing Stock Solutions
for Sildenafil citrate
The following data is based on the product molecular weight 666.70
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.50 mL | 7.50 mL | 15.00 mL |
| 5 mM | 0.30 mL | 1.50 mL | 3.00 mL |
| 10 mM | 0.15 mL | 0.75 mL | 1.50 mL |
| 50 mM | 0.03 mL | 0.15 mL | 0.30 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Smith-Berdan Viagra enables efficient, single-day hematopoietic stem cell mobilization. Stem Cell Reports. 2019 PMID: 31607567
- Turko Inhibition of cyclic cGMP-binding cyclic GMP-specific phosphodiesterase (type 5) by silde. and related compounds. Mol.Pharmacol. 1999 PMID: 10385692
- Ghofrani Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond. Nat.Rev.Drug Discov. 2006 PMID: 16883306
- Ballard Effects of silde. on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. J.Urol. 1998 PMID: 9598563
Product Specific Notices for Sildenafil citrate
For research use only
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