(R)-(-)-Rolipram
Tocris Bioscience, part of Bio-Techne | Catalog # 1349
PDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905)
Key Product Details
Description
PDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905)
Product Description
(R)-(-)-Rolipram is a more active enantiomer of the PDE4 inhibitor rolipram; 2-10-fold more potent than the S-(+) enantiomer.Racemate and S-enantiomer also available.
Product Specifications
Molecular Weight
275.35
Formula
C16H21NO3
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
CAS Number
85416-75-7
PubChem ID
448055
InChI Key
HJORMJIFDVBMOB-LBPRGKRZSA-N
SMILES
O=C1NC[C@@H](C2=CC(OC3CCCC3)=C(OC)C=C2)C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.54 | 100 | |
| Ethanol | 27.54 | 100 |
Preparing Stock Solutions
for (R)-(-)-Rolipram
The following data is based on the product molecular weight 275.35
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.63 mL | 18.16 mL | 36.32 mL |
| 5 mM | 0.73 mL | 3.63 mL | 7.26 mL |
| 10 mM | 0.36 mL | 1.82 mL | 3.63 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.73 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Owens Human phosphodiesterase 4A: characterization of full-length and truncated enzymes expressed in COS cells. Biochem.J. 1997 PMID: 9337850
- Schneider Stereospecific binding of the antidepressant rolipram to brain protein structures. Eur.J.Pharmacol. 1986 PMID: 3019721
- Ohsawa Inhibitory effects of rolipram on partially purified phosphodiesterase 4 from rat brains. Jpn.J.Pharmacol. 1998 PMID: 9681571
Product Specific Notices for (R)-(-)-Rolipram
For research use only
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