PF 05180999
Tocris Bioscience, part of Bio-Techne | Catalog # 6405
Potent and selective PDE2A inhibitor
Key Product Details
Description
Potent and selective PDE2A inhibitor
Product Description
PF 05180999 is a potent and selective PDE2A inhibitor (IC50 = 1 nM). Exhibits 2000-fold selectivity for PDE2A over PDE10A. Brain penetrant.Licensing Information
Sold for research purposes under agreement from Pfizer Inc.Product Specifications
Molecular Weight
414.39
Formula
C19H17F3N8
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-(1-Azetidinyl)-7-methyl-5-[1-methyl-5-[5-(trifluoromethyl)-2-pyridinyl]-1H-pyrazol-4-yl]-imidazo[5,1-f][1,2,4]triazine
CAS Number
1394033-54-5
PubChem ID
60143346
InChI Key
CLGCHUKGBICQTE-UHFFFAOYSA-N
SMILES
CC1=NC(C2=C(C3=NC=C(C(F)(F)F)C=C3)N(C)N=C2)=C4N1N=CN=C4N5CCC5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.72 | 50 | |
| Ethanol | 20.72 | 50 |
Preparing Stock Solutions
for PF 05180999
The following data is based on the product molecular weight 414.39
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.83 mL | 24.13 mL | 48.26 mL |
| 2.5 mM | 0.97 mL | 4.83 mL | 9.65 mL |
| 5 mM | 0.48 mL | 2.41 mL | 4.83 mL |
| 25 mM | 0.10 mL | 0.48 mL | 0.97 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mikami Discovery of orally bioavailable brain penetrating in vivo active phosphodiesterase 2a inhibitor series for the treatment of cognitive disorders. J.Med.Chem. 2017 PMID: 28759228
Product Specific Notices for PF 05180999
For research use only
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