Zaprinast

Name: Zaprinast
Brand: Tocris Bioscience
SKU: 0947

Tocris Bioscience a Bio-Techne Brand

Catalog # 0947

Citations (6)

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Key Product Details

Description:	GPR35 agonist
Chemical Name:	2-(2-Propyloxyphenyl)-8-azapurin-6-one
Purity:	≥98% (HPLC)
Molecular Weight:	271.28

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Biological Activity for Zaprinast

Zaprinast is a phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC₅₀ values are 0.15, 0.76, 12.0 and 29.0 μM respectively). Putative GPR35 agonist.

Compound Libraries for Zaprinast

Zaprinast is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Zaprinast

M. Wt	271.28
Formula	C₁₃H₁₃N₅O₂
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	37762-06-4
PubChem ID	5722
InChi Key	REZGGXNDEMKIQB-UHFFFAOYSA-N
Smiles	CCCOC1=C(C=CC=C1)C1=NC2=C(NN=N2)C(=O)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Zaprinast

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO		100

Preparing Stock Solutions for Zaprinast

The following data is based on the product molecular weight 271.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.69 mL	18.43 mL	36.86 mL
5 mM	0.74 mL	3.69 mL	7.37 mL
10 mM	0.37 mL	1.84 mL	3.69 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

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References for Zaprinast

References are publications that support the biological activity of the product.

Lugnier Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents. Pharmacol.Ther. 2006 PMID: 16102838
Taniguchi Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35. FEBS Lett. 2006 PMID: 16934253
Soderling Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases. J.Biol.Chem. 1998 PMID: 9624145
Christensen and Torphy Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents. Annu.Rep.Med.Chem.

Citations for Zaprinast (6)

Showing 1 - 6 of 6 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Zaprinast include:

Wyant et al. (2022) Mitochondrial remodeling and ischemic protection by G protein�coupled receptor 35 agonists. Science. 377:621
PMID: 35926043
Rojewska (2018) Kynurenic acid and zaprinast diminished CXCL17-evoked pain-related behaviour and enhanced mor. analgesia in a mouse neuropathic pain model. Pharmacol Rep. 71:139
PMID: 30550994
MacKenzie et al. (2014) The antiallergic mast cell stabilizers lodox. and bufrolin as the first high and equipotent agonists of human and rat GPR35. Mol Pharmacol. 85:91
PMID: 24113750
Polcari et al. (2013) Effect of the phosphodiesterase-5 inhibitor zaprinast on ischemia-reperfusion injury in rats. Proc Natl Acad Sci U S A. 27:338
PMID: 22974473
Zerani et al. (2004) Ob receptor in rabbit ovary and leptin in vitro regulation of corpora lutea. J Endourol. 183:279
PMID: 15531716
Robichaud et al. (2002) Assessing the emetic potential of PDE4 inhibitors in rats. Br J Pharmacol. 135:113
PMID: 11786486

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