Cilostamide

Name: Cilostamide
Brand: tocris
SKU: 0915

Catalog # 0915

Citations (5)

Datasheet / COA / SDS

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Bio-Techne Corporation

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Key Product Details

Description:	PDE3 inhibitor
Alternative Names:	OCP 3689
Chemical Name:	N-Cyclohexyl-N-methyl-4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyramide
Purity:	≥97% (HPLC)
Molecular Weight:	342.44

View Full Technical Details for Cilostamide

Technical Data
Citations (5) / Reviews

Biological Activity

Cilostamide is a selective inhibitor of type III phosphodiesterase (PDE3). Displays moderate selectivity for PDE3A isozyme vs. PDE3B (IC₅₀ values are 0.027 and 0.050 μM for PDE3A and PDE3B respectively). Inhibits ADP-induced platelet aggregation (IC₅₀ = 16.8 μM); antithrombotic.

Technical Data

M. Wt	342.44
Formula	C₂₀H₂₆N₂O₃
Storage	Store at RT
Purity	≥97% (HPLC)
CAS Number	68550-75-4
PubChem ID	2753
InChi Key	UIAYVIIHMORPSJ-UHFFFAOYSA-N
Smiles	CN(C1CCCCC1)C(=O)CCCOC1=CC=C2NC(=O)C=CC2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	6.85	20 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 342.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	14.60 mL	73.01 mL	146.01 mL
1 mM	2.92 mL	14.60 mL	29.20 mL
2 mM	1.46 mL	7.30 mL	14.60 mL
10 mM	0.29 mL	1.46 mL	2.92 mL

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References

References are publications that support the biological activity of the product.

Hidaki Selective inhibitor of platelet cyclic adenosine monophosphate phosphodiesterase, cilostamide, inhibits platelet aggregation. J.Pharmacol.Exp.Ther. 1979 PMID: 226672
Sudo Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity. Biochem.Pharmacol. 2000 PMID: 10644042
Christensen and Torphy Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents. Annu.Rep.Med.Chem.

Citations (5)

Showing 1 - 5 of 5 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Cilostamide include:

Merino et al. (2015) Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with isoprote. PLoS One. 10:e0132884
PMID: 26222156
Ørstavik et al. (2015) The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium. J Biol Chem. 10:e0115547
PMID: 25738589
Hubert et al. (2014) Alteration of vascular reactivity in heart failure: role of phosphodiesterases 3 and 4. Br J Pharmacol. 171:5361
PMID: 25048877
Brunet et al. (2013) Increased intracellular magnesium attenuates β-adrenergic stimulation of the cardiac Ca(V)1.2 channel. J Gen Physiol. 141:85
PMID: 23250865
Zhai et al. (2012) β-Adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells. PLoS One. 7:e47826
PMID: 23094097

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Showing 1 - 5 of 5 citations Showing All

Product Datasheets

COA

Certificate of Analysis

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Cilostamide

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Key Product Details

Biological Activity

Technical Data

Solubility

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Citations (5)

Product Datasheets

COA

Certificate of Analysis

SDS

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