Dipyridamole

Name: Dipyridamole
Brand: Tocris Bioscience
SKU: 0691
Price: 99 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 0691

Citations (3)

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Key Product Details

Description:	Adenosine transport inhibitor
Chemical Name:	2,6-bis(Diethanolamino)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine
Purity:	≥99% (HPLC)
Molecular Weight:	504.63

View Full Technical Details for Dipyridamole

Biological Activity for Dipyridamole

Dipyridamole is a coronary vasodilator; adenosine transport inhibitor. Phosphodiesterase inhibitor (IC₅₀ values are 0.37, 0.38, 0.45, 0.9 and 4.5 μM for PDE11, 6, 10, 5 and 8 respectively). Inhibits ENT1 and ENT2 (IC₅₀ = 144.8 nM and K_i = 8.18 nM for ENT1).

Compound Libraries for Dipyridamole

Dipyridamole is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Dipyridamole

M. Wt	504.63
Formula	C₂₄H₄₀N₈O₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	58-32-2
PubChem ID	3108
InChi Key	IZEKFCXSFNUWAM-UHFFFAOYSA-N
Smiles	OCCN(CCO)C1=NC(N2CCCCC2)=C2N=C(N=C(N3CCCCC3)C2=N1)N(CCO)CCO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Dipyridamole

	Solvent	Max Conc. mM
Solubility
	DMSO	100
	ethanol	10

Preparing Stock Solutions for Dipyridamole

The following data is based on the product molecular weight 504.63.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.98 mL	9.91 mL	19.82 mL
5 mM	0.40 mL	1.98 mL	3.96 mL
10 mM	0.20 mL	0.99 mL	1.98 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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Reconstitution Calculator

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References for Dipyridamole

References are publications that support the biological activity of the product.

Lin and Buolamwini Synthesis, flow cytometric evaluation, and identification of highly potent dipyrid. analogues as equilibrative nucleoside transporter 1 inhibitors. J.Med.Chem. 2007 PMID: 17636949
Fujishige Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A). J.Biol.Chem. 1999 PMID: 10373451
Meester Pharmacological analysis of the activity of the adenosine uptake inhibitor, dipyridamole, on the sinoatrial and atrioventricular nodes of the guinea-pig. Br.J.Pharmacol. 1998 PMID: 9690865
Soderling Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. Proc.Natl.Acad.Sci.U.S.A. 1998 PMID: 9671792

Citations for Dipyridamole (3)

Showing 1 - 3 of 3 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Dipyridamole include:

Davidson et al. (2016) Alkaline Phosphatase, Soluble Extracellular Adenine Nucleotides, and Adenosine Production after Infant Cardiopulmonary Bypass PLoS One. 11:e0158981
PMID: 27384524
Cunha et al. (2015) Creatine, similarly to KA, affords antidepressant-like effects in the tail suspension test via adenosine A1� and A2A receptor activation. Sci Rep. 11:215
PMID: 25702084
Nguyen et al. (2015) Clearance of rapid adenosine release is regulated by nucleoside transporters and metabolism. Pharmacol Res Perspect. 3:e00189
PMID: 27022463

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