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Caffeine

Tocris Bioscience a Bio-Techne Brand

Caffeine | CAS No. 58-08-2 | A1 and A2B antagonist. CNS stimulant
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Key Product Details

Description: A1 and A2B antagonist. CNS stimulant
Chemical Name: 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
Purity: ≥99% (HPLC)
Molecular Weight: 194.19

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Citations for Caffeine (2)

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Customer Reviews for Caffeine (3)

4.7 out of 5
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  • Low-dose oral caffeine induces a specific form of behavioral sensitization
    Name: Kevin Ball
    Species: Rat
    Assay Type: In Vivo
    Rats had free access to untreated water or water containing 0.2 mg/ml of caffeine every other day of a 14-day experiment. This dose is relevant to human caffeine intake. Rats were tested on alternated days in an open-field arena for discrete movements (horizontal and vertical) and ambulatory distance. Results showed that although caffeine intake decreased significantly across test sessions, the number of discrete horizontal movements increased significantly, that is, showed sensitization.
    Caffeine Serum 2793
  • Caffeine acts on RyR2 in HL1 cells to release ER Ca2+.
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: HL-1 Atrial Muscle Cell Line
    HL-1 cells were loaded with cytosolic Ca2+ sensitive dye, Fura-2AM (1 µM)+F127 (0.01%) in normal tyrode solution for 40 min and excited alternately at 340 and 380 nm and fluorescence was captured at 510 nm. When the cells are perfused with 10 mM caffeine in nominally Ca2+ free tyrode solution, caffeine acts on RyR2 to release ER Ca2+, resulting in transient cytosolic peak (shown in the figure).
    Caffeine Serum 2793
  • Caffeine as a tool to estimate sarcoplasmic Ca2+ content in cardiomyocytes
    Name: Christopher Trummer
    Species: Other
    Assay Type: In Vitro
    Cell Line/Tissue: primary ventricular cardiomyocytes
    Control or saxagliptin treated primary guinea pig cardiomyocytes were loaded with FURA-2AM (1 µM) and Pluronic F 127 (1%). Ca2+ transient decay tau evoked by caffeine (30 µM) is shown in the Image. Caffeine acts as a ryanodine receptor agonist and releases Ca2+ from sarcoplasmic reticulum into the cytosol.
    Caffeine Serum 2793

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Product Documents for Caffeine

Certificate of Analysis

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