Caffeine
Tocris Bioscience, part of Bio-Techne | Catalog # 2793
A1 and A2B antagonist. CNS stimulant
Key Product Details
Description
A1 and A2B antagonist. CNS stimulant
Product Description
Caffeine is a central nervous system stimulant. Antagonist at A1 and A2A adenosine receptors and inhibitor of cyclic nucleotide phosphodiesterases. Mobilizes calcium from intracellular stores and inhibits benzodiazepine binding to GABA receptors.Product Specifications
Molecular Weight
194.19
Formula
C8H10N4O2
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
CAS Number
58-08-2
PubChem ID
2519
InChI Key
RYYVLZVUVIJVGH-UHFFFAOYSA-N
SMILES
O=C1C2=C(N=CN2C)N(C)C(N1C)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 19.42 | 100 | |
| DMSO | 9.71 | 50 |
Preparing Stock Solutions
for Caffeine
The following data is based on the product molecular weight 194.19
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.15 mL | 25.75 mL | 51.50 mL |
| 5 mM | 1.03 mL | 5.15 mL | 10.30 mL |
| 10 mM | 0.51 mL | 2.57 mL | 5.15 mL |
| 50 mM | 0.10 mL | 0.51 mL | 1.03 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Fisone Caffeine as a psychomotor stimulant: mechanism of action. Cell.Mol.Life Sci. 2004 PMID: 15095008
- Chen Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease. J.Neuroinflammation 2008 PMID: 18387175
- Nehlig Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain Res.Brain Res.Rev. 1992 PMID: 1356551
Product Specific Notices for Caffeine
For research use only
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