Caffeine

Name: Caffeine
Brand: Tocris Bioscience
SKU: 2793
Rating: 5 (3 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2793

(3)

Citations (46)

COA / SDS

A1 and A2B antagonist. CNS stimulant

Key Product Details

Description:	A₁ and A_2B antagonist. CNS stimulant
Chemical Name:	3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
Purity:	≥98% (HPLC)
Molecular Weight:	194.19

View Full Technical Details for Caffeine

Technical Data
Citations / Reviews (3)

Biological Activity for Caffeine

Caffeine is a central nervous system stimulant. Antagonist at A₁ and A_2A adenosine receptors and inhibitor of cyclic nucleotide phosphodiesterases. Mobilizes calcium from intracellular stores and inhibits benzodiazepine binding to GABA receptors.

Technical Data for Caffeine

M. Wt	194.19
Formula	C₈H₁₀N₄O₂
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	58-08-2
PubChem ID	2519
InChi Key	RYYVLZVUVIJVGH-UHFFFAOYSA-N
Smiles	O=C1C2=C(N=CN2C)N(C)C(N1C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Caffeine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	19.42	100
	DMSO	9.71	50

Preparing Stock Solutions for Caffeine

The following data is based on the product molecular weight 194.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.15 mL	25.75 mL	51.50 mL
5 mM	1.03 mL	5.15 mL	10.30 mL
10 mM	0.51 mL	2.57 mL	5.15 mL
50 mM	0.10 mL	0.51 mL	1.03 mL

Molarity Calculator

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Reconstitution Calculator

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References for Caffeine

References are publications that support the biological activity of the product.

Fisone Caffeine as a psychomotor stimulant: mechanism of action. Cell.Mol.Life Sci. 2004 PMID: 15095008
Chen Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease. J.Neuroinflammation 2008 PMID: 18387175
Nehlig Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain Res.Brain Res.Rev. 1992 PMID: 1356551