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PD-1 Products

PD-1 (Programmed Death-1 receptor) is a key regulator of the threshold of immune response and peripheral immune tolerance. It is expressed on activated T cells, B cells, monocytes, and dendritic cells and binds to PD-L1 or PD-L2. PD-1 ligation induces co-inhibitory signals in T cells promoting their apoptosis, anergy, and functional exhaustion. Many tumors overexpress PD-L1 to induce this inhibitory signaling pathway in immune cells. When PD-1 expressing immune cells come into contact with a tumor cell expressing PD-L1, this interaction blocks activation and prevents an immune response. A new class of anti-cancer therapies disrupt these co-inhibitory signals taking the breaks off the host immune system thereby enhancing anti-tumor immunity.  Recent success of several antibody therapeutics has spurred great interest in PD-1 and PD-L1 in addition to other co-inhibitory immune checkpoint proteins.

605 results for "PD-1" in Products

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PD-1 Products

PD-1 (Programmed Death-1 receptor) is a key regulator of the threshold of immune response and peripheral immune tolerance. It is expressed on activated T cells, B cells, monocytes, and dendritic cells and binds to PD-L1 or PD-L2. PD-1 ligation induces co-inhibitory signals in T cells promoting their apoptosis, anergy, and functional exhaustion. Many tumors overexpress PD-L1 to induce this inhibitory signaling pathway in immune cells. When PD-1 expressing immune cells come into contact with a tumor cell expressing PD-L1, this interaction blocks activation and prevents an immune response. A new class of anti-cancer therapies disrupt these co-inhibitory signals taking the breaks off the host immune system thereby enhancing anti-tumor immunity.  Recent success of several antibody therapeutics has spurred great interest in PD-1 and PD-L1 in addition to other co-inhibitory immune checkpoint proteins.

605 results for "PD-1" in Products

Analyzed by SEC-MALS

WB, Flow, IHC, Block, CyTOF-ready

Analyzed by SEC-MALS

BA
WB, Flow, IHC, CyTOF-ready
ELISA, ICC/IF, IHC, WB
Flow

Recombinant Monoclonal Antibody.

WB, ELISA, IHC, Block
BA

Biotinylated

WB, Flow, Block, CyTOF-ready

Recombinant Monoclonal Antibody.

Contains 4 membranes - each spotted in duplicate with 59 different immunoreceptor antibodies

Flow, CyTOF-ready
BA
BA
WB, Flow, IHC
Neut
BA

Biotinylated

WB, ELISA, Flow, CyTOF-ready

Recombinant Monoclonal Antibody.

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