PD-1: Antibodies
PD-1 (Programmed Death-1 receptor) is a key regulator of the threshold of immune response and peripheral immune tolerance. It is expressed on activated T cells, B cells, monocytes, and dendritic cells and binds to PD-L1 or PD-L2. PD-1 ligation induces co-inhibitory signals in T cells promoting their apoptosis, anergy, and functional exhaustion. Many tumors overexpress PD-L1 to induce this inhibitory signaling pathway in immune cells. When PD-1 expressing immune cells come into contact with a tumor cell expressing PD-L1, this interaction blocks activation and prevents an immune response. A new class of anti-cancer therapies disrupt these co-inhibitory signals taking the breaks off the host immune system thereby enhancing anti-tumor immunity. Recent success of several antibody therapeutics has spurred great interest in PD-1 and PD-L1 in addition to other co-inhibitory immune checkpoint proteins.
79 results for "PD-1 Primary Antibodies" in Products
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PD-1: Antibodies
PD-1 (Programmed Death-1 receptor) is a key regulator of the threshold of immune response and peripheral immune tolerance. It is expressed on activated T cells, B cells, monocytes, and dendritic cells and binds to PD-L1 or PD-L2. PD-1 ligation induces co-inhibitory signals in T cells promoting their apoptosis, anergy, and functional exhaustion. Many tumors overexpress PD-L1 to induce this inhibitory signaling pathway in immune cells. When PD-1 expressing immune cells come into contact with a tumor cell expressing PD-L1, this interaction blocks activation and prevents an immune response. A new class of anti-cancer therapies disrupt these co-inhibitory signals taking the breaks off the host immune system thereby enhancing anti-tumor immunity. Recent success of several antibody therapeutics has spurred great interest in PD-1 and PD-L1 in addition to other co-inhibitory immune checkpoint proteins.
79 results for "PD-1 Primary Antibodies" in Products
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Block/Neutralize, CyTOF-ready, ELISA Capture, Flow Cytometry, Immunohistochemistry, Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | CyTOF-ready, Flow Cytometry, Immunohistochemistry, Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | ELISA Detection, Flow Cytometry, Western Blot |
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #913429 |
Applications : | Block/Neutralize, CyTOF-ready, Flow Cytometry, Western Blot |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #1015846 |
Applications : | Block/Neutralize, ELISA, Immunohistochemistry, Western Blot |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #192106 |
Applications : | Western Blot |
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Rabbit IgG Clone #2335A |
Applications : | CyTOF-ready, ELISA, Flow Cytometry, Western Blot |
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Human IgG4 Kappa Clone #Hu121 |
Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Human IgG1 Clone #Hu121 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #766104 |
Applications : | CyTOF-ready, Flow Cytometry |
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #913429 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #996209 |
Applications : | Block/Neutralize |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #1015829 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG2a Clone #1026901 |
Applications : | Immunohistochemistry |
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #996221 |
Applications : | CyTOF-ready, Flow Cytometry, Western Blot |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #1002313 |
Applications : | CyTOF-ready, Flow Cytometry, Western Blot |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #1026519 |
Applications : | CyTOF-ready, Flow Cytometry, Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Flow Cytometry, Immunohistochemistry, Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #766104 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #1015829 |
Applications : | Block/Neutralize, Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #996221 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #766104 |
Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Rabbit IgG Clone #2335A |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #766104 |
Applications : | Flow Cytometry |