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GABA-B R1: Small Molecules and Peptides

The neurotransmitter gamma-aminobutyric acid (GABA) mediates an inhibitory signal upon binding to two ligand-gated channels, GABA-A and GABA-C receptors, and a G protein-coupled receptor (GPCR), GABA-B. The GABA-B receptor is a heterodimeric complex composed of two 7-transmembrane GPCRs termed GABA-B R1 and GABA-B R2. GABA-B receptors have been implicated in the GABA-induced modulation of sympathetic and catecholaminergic pathways in the central nervous system.

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14 results for "GABA-B R1 Small Molecules and Peptides" in Products

14 results for "GABA-B R1 Small Molecules and Peptides" in Products

GABA-B R1: Small Molecules and Peptides

The neurotransmitter gamma-aminobutyric acid (GABA) mediates an inhibitory signal upon binding to two ligand-gated channels, GABA-A and GABA-C receptors, and a G protein-coupled receptor (GPCR), GABA-B. The GABA-B receptor is a heterodimeric complex composed of two 7-transmembrane GPCRs termed GABA-B R1 and GABA-B R2. GABA-B receptors have been implicated in the GABA-induced modulation of sympathetic and catecholaminergic pathways in the central nervous system.

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Potent and selective GABAB antagonist

Chemical Name: (2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl)phosphinic acid hydrochloride
Purity: ≥98% (HPLC)
Potent and selective GABAB antagonist

Potent and selective GABAB antagonist

Chemical Name: [S-(R*,R*)]-[3-[[1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](cyclohexylmethyl) phosphinic acid
Purity: ≥96% (HPLC)
Potent and selective GABAB antagonist

Selective GABAB antagonist; brain penetrant

Chemical Name: (3-Aminopropyl)(diethoxymethyl)phosphinic acid
Selective GABAB antagonist; brain penetrant

Selective GABAB agonist

Chemical Name: (RS)-4-Amino-3-(4-chlorophenyl)butanoic acid
Purity: ≥99% (HPLC)
Selective GABAB agonist

Selective GABAB agonist; active enantiomer of (RS)-Baclofen (Cat. No. 0417)

Alternate Names: STX 209
Chemical Name: (R)-4-Amino-3-(4-chlorophenyl)butanoic acid
Purity: ≥99% (HPLC)
Selective GABAB agonist; active enantiomer of (RS)-Baclofen (Cat. No. 0417)

Selective and competitive GABAB antagonist; orally bioavailable

Chemical Name: (2S)-(+)-5,5-Dimethyl-2-morpholineacetic acid
Purity: ≥98%
Selective and competitive GABAB antagonist; orally bioavailable

Selective GABAB antagonist

Chemical Name: (RS)-3-Amino-2-(4-chlorophenyl)propylsulfonic acid
Purity: ≥98% (HPLC)
Selective GABAB antagonist

Potent and selective GABAB antagonist

Chemical Name: 3-[[(3,4-Dichlorophenyl)methyl]amino]propyl] diethoxymethyl)phosphinic acid
Purity: ≥98% (HPLC)
Potent and selective GABAB antagonist

Selective GABAB antagonist; more potent than Saclofen (Cat. No. 0246)

Chemical Name: (RS)-3-Amino-2-(4-chlorophenyl)-2-hydroxypropyl-sulfonic acid
Selective GABAB antagonist; more potent than Saclofen (Cat. No. 0246)

Potent and selective postitive allosteric modulator of GABAB receptors

Chemical Name: 5,7-Bis(1,1-dimethylethyl)-3-hydroxy-3(trifluoromethyl)-2(3H)-benzofuranone
Purity: ≥98% (HPLC)
Potent and selective postitive allosteric modulator of  GABAB receptors

Positive allosteric modulator of GABAB receptors

Chemical Name: 3,5-bis(1,1-Dimethylethyl)-4-hydroxy-β,β-dimethyl-benzenepropanol
Purity: ≥98% (HPLC)
Positive allosteric modulator of GABAB receptors

Positive allosteric modulator of GABAB receptors

Chemical Name: N,N'-Dicyclopentyl-2-(methylthio)-5-nitro-4,6-pyrimidinediamine
Purity: ≥98% (HPLC)
Positive allosteric modulator of GABAB receptors

GABAB antagonist; displays activity at presynaptic receptors

Chemical Name: (3-Aminopropyl)ethylphosphinic acid hydrochloride
Purity: ≥98% (HPLC)
GABAB antagonist; displays activity at presynaptic receptors

Caged GABA; inhibits neural activity

Alternate Names: RuBi-GABA-PMe3
Chemical Name: (bis(2,2'-Bipyridine-N,N')trimethylphosphine)-4-aminobutyric acid ruthenium complex sodium hexafluorophosphate salt
Caged GABA; inhibits neural activity
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