SKF 97541

Name: SKF 97541
Brand: Tocris Bioscience
SKU: 0379

Tocris Bioscience a Bio-Techne Brand

Catalog # 0379

Citations (8)

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Key Product Details

Description:	Highly potent GABA_B agonist; also GABA_A-ρ antagonist
Alternative Names:	CGP 35024
Chemical Name:	3-Aminopropyl(methyl)phosphinic acid
Molecular Weight:	137.12

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Biological Activity for SKF 97541

SKF 97541 is a potent GABA_B agonist (EC₅₀ = 50 nM). SKF 97541 depresses striatal synaptic potentials and hyperpolarizes nigral neurons (EC₅₀ values = 92 nM and 150 nM, respectively). SKF 97541 shows antidepressant effects in animal models and is also a GABA_A-ρ antagonist.

Technical Data for SKF 97541

M. Wt	137.12
Formula	C₄H₁₂NO₂P
Storage	Desiccate at RT
CAS Number	127729-35-5
PubChem ID	5230
InChi Key	NHVRIDDXGZPJTJ-UHFFFAOYSA-N
Smiles	NCCCP(O)(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SKF 97541

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	13.71	100

Preparing Stock Solutions for SKF 97541

The following data is based on the product molecular weight 137.12.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	7.29 mL	36.46 mL	72.93 mL
5 mM	1.46 mL	7.29 mL	14.59 mL
10 mM	0.73 mL	3.65 mL	7.29 mL
50 mM	0.15 mL	0.73 mL	1.46 mL

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References for SKF 97541

References are publications that support the biological activity of the product.

Bon and Galvan Electrophysiological characterization of GABA_B agonists and antagonists in dorso-lateral septal neurones in vitro. Br.J.Pharmacol. 1996 PMID: 8799569
Johnston GABA_C receptors: relatively simple transmitter-gated ion channels? TiPS 1996 PMID: 8885697
Froestl Phosphinic acid analogues of GABA. 1. New potent and selective GABA_B agonists. J.Med.Chem. 1995 PMID: 7650684
Seabrook Electrophysiological characterization of potent agonists and antagonists on pre- and postsynaptic GABA_B receptors on neurones in brain slices. Br.J.Pharmacol. 1990 PMID: 1964824

Citations for SKF 97541 (8)

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Citations are publications that use Bio-Techne products. Selected citations for SKF 97541 include:

Martelli and Fiala (2019) Slow presynaptic mechanisms that mediate adaptation in the olfactory pathway of Drosophila. Elife. 8
PMID: 31169499
Ki and Lim (2019) Sleep-promoting effects of threonine link amino acid metabolism in Drosophila neuron to GABAergic control of sleep drive. Elife. 8
PMID: 31313987
Lecat-Guillet (2017) FRET-based sensors unravel activation and allosteric modulation of the GABAB receptor. Cell Chem Biol. 24(3):360
PMID: 28286129
Ignell et al. (2009) Presynaptic peptidergic modulation of olfactory receptor neurons in Drosophila. Br J Pharmacol. 106:13070
PMID: 19625621
Root et al. (2008) A presynaptic gain control mechanism fine-tunes olfactory behavior. Neuron. 59:311
PMID: 18667158
Chen et al. (2008) Differential regulation of mor. antinociceptive effects by endogenous enkephalinergic system in the forebrain of mice. Mol Pain. 4:41
PMID: 18826595
Piqueras and Martínez (2004) Peripheral GABAB agonists stimulate gastric acid secretion in mice. Br J Pharmacol. 142:1038
PMID: 15210585
Wood et al. (2000) The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. Mol Pain. 131:1050
PMID: 11082110

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