GABA-B R1: Small Molecules and Peptides
The neurotransmitter gamma-aminobutyric acid (GABA) mediates an inhibitory signal upon binding to two ligand-gated channels, GABA-A and GABA-C receptors, and a G protein-coupled receptor (GPCR), GABA-B. The GABA-B receptor is a heterodimeric complex composed of two 7-transmembrane GPCRs termed GABA-B R1 and GABA-B R2. GABA-B receptors have been implicated in the GABA-induced modulation of sympathetic and catecholaminergic pathways in the central nervous system.
Products:
14 results for "GABA-B R1 Small Molecules and Peptides" in Products
14 results for "GABA-B R1 Small Molecules and Peptides" in Products
GABA-B R1: Small Molecules and Peptides
The neurotransmitter gamma-aminobutyric acid (GABA) mediates an inhibitory signal upon binding to two ligand-gated channels, GABA-A and GABA-C receptors, and a G protein-coupled receptor (GPCR), GABA-B. The GABA-B receptor is a heterodimeric complex composed of two 7-transmembrane GPCRs termed GABA-B R1 and GABA-B R2. GABA-B receptors have been implicated in the GABA-induced modulation of sympathetic and catecholaminergic pathways in the central nervous system.
Products:
Potent and selective GABAB antagonist
| Chemical Name: | (2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl)phosphinic acid hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent and selective GABAB antagonist
| Chemical Name: | [S-(R*,R*)]-[3-[[1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](cyclohexylmethyl) phosphinic acid |
| Purity: | ≥96% (HPLC) |
Selective GABAB antagonist; more potent than Saclofen (Cat. No. 0246)
| Chemical Name: | (RS)-3-Amino-2-(4-chlorophenyl)-2-hydroxypropyl-sulfonic acid |
Selective GABAB antagonist
| Chemical Name: | (RS)-3-Amino-2-(4-chlorophenyl)propylsulfonic acid |
| Purity: | ≥98% (HPLC) |
Selective GABAB agonist; active enantiomer of (RS)-Baclofen (Cat. No. 0417)
| Alternate Names: | STX 209 |
| Chemical Name: | (R)-4-Amino-3-(4-chlorophenyl)butanoic acid |
| Purity: | ≥99% (HPLC) |
Selective and competitive GABAB antagonist; orally bioavailable
| Chemical Name: | (2S)-(+)-5,5-Dimethyl-2-morpholineacetic acid |
| Purity: | ≥98% |
Selective GABAB antagonist; brain penetrant
| Chemical Name: | (3-Aminopropyl)(diethoxymethyl)phosphinic acid |
Potent and selective GABAB antagonist
| Chemical Name: | 3-[[(3,4-Dichlorophenyl)methyl]amino]propyl] diethoxymethyl)phosphinic acid |
| Purity: | ≥98% (HPLC) |
Potent and selective postitive allosteric modulator of GABAB receptors
| Chemical Name: | 5,7-Bis(1,1-dimethylethyl)-3-hydroxy-3(trifluoromethyl)-2(3H)-benzofuranone |
| Purity: | ≥98% (HPLC) |
Selective GABAB agonist
| Chemical Name: | (RS)-4-Amino-3-(4-chlorophenyl)butanoic acid |
| Purity: | ≥99% (HPLC) |
Positive allosteric modulator of GABAB receptors
| Chemical Name: | 3,5-bis(1,1-Dimethylethyl)-4-hydroxy-β,β-dimethyl-benzenepropanol |
| Purity: | ≥98% (HPLC) |
Positive allosteric modulator of GABAB receptors
| Chemical Name: | N,N'-Dicyclopentyl-2-(methylthio)-5-nitro-4,6-pyrimidinediamine |
| Purity: | ≥98% (HPLC) |
GABAB antagonist; displays activity at presynaptic receptors
| Chemical Name: | (3-Aminopropyl)ethylphosphinic acid hydrochloride |
| Purity: | ≥98% (HPLC) |
Caged GABA; inhibits neural activity
| Alternate Names: | RuBi-GABA-PMe3 |
| Chemical Name: | (bis(2,2'-Bipyridine-N,N')trimethylphosphine)-4-aminobutyric acid ruthenium complex sodium hexafluorophosphate salt |
