2-Hydroxysaclofen

Name: 2-Hydroxysaclofen
Brand: Tocris Bioscience
SKU: 0245

Tocris Bioscience a Bio-Techne Brand

Catalog # 0245

Citations (2)

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Key Product Details

Description:	Selective GABA_B antagonist; more potent than Saclofen (Cat. No. 0246)
Chemical Name:	(RS)-3-Amino-2-(4-chlorophenyl)-2-hydroxypropyl-sulfonic acid
Molecular Weight:	265.71

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Biological Activity for 2-Hydroxysaclofen

2-Hydroxysaclofen is a selective antagonist at GABA_B receptors.

Technical Data for 2-Hydroxysaclofen

M. Wt	265.71
Formula	C₉H₁₂ClNO₄S
Storage	Store at RT
CAS Number	117354-64-0
PubChem ID	1564
InChi Key	WBSMZVIMANOCNX-UHFFFAOYSA-N
Smiles	NCC(O)(CS(O)(=O)=O)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 2-Hydroxysaclofen

	Solvent	Max Conc. mM
Solubility
	water	5
	1eq. NaOH	100

Preparing Stock Solutions for 2-Hydroxysaclofen

The following data is based on the product molecular weight 265.71.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.76 mL	18.82 mL	37.64 mL
5 mM	0.75 mL	3.76 mL	7.53 mL
10 mM	0.38 mL	1.88 mL	3.76 mL
50 mM	0.08 mL	0.38 mL	0.75 mL

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References for 2-Hydroxysaclofen

References are publications that support the biological activity of the product.

Curtis Baclofen antagonism by 2-hydroxysaclofen in the cat spinal cord. Neurosci.Lett. 1988 PMID: 2847093
Kerr 2-Hydroxysaclofen: an improved antagonist at central and peripheral GABA_B receptors. Neurosci.Lett. 1988 PMID: 2847092

Citations for 2-Hydroxysaclofen (2)

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Citations are publications that use Bio-Techne products. Selected citations for 2-Hydroxysaclofen include:

Piqueras and Martínez (2004) Peripheral GABAB agonists stimulate gastric acid secretion in mice. Br J Pharmacol. 142:1038
PMID: 15210585
Piet et al. (2004) Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk. Nature. 101:2151
PMID: 14766975

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