2-Hydroxysaclofen
Tocris Bioscience, part of Bio-Techne | Catalog # 0245
Selective GABAB antagonist; more potent than Saclofen (Cat. No. 0246)
Key Product Details
Description
Selective GABAB antagonist; more potent than Saclofen (Cat. No. 0246)
Product Description
2-Hydroxysaclofen is a selective antagonist at GABAB receptors.Product Specifications
Molecular Weight
265.71
Formula
C9H12ClNO4S
Storage
Store at RT
Chemical Name
(RS)-3-Amino-2-(4-chlorophenyl)-2-hydroxypropyl-sulfonic acid
CAS Number
117354-64-0
PubChem ID
1564
InChI Key
WBSMZVIMANOCNX-UHFFFAOYSA-N
SMILES
NCC(O)(CS(O)(=O)=O)C1=CC=C(Cl)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 5 | ||
| 1eq. NaOH | 100 |
Preparing Stock Solutions
for 2-Hydroxysaclofen
The following data is based on the product molecular weight 265.71
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.76 mL | 18.82 mL | 37.64 mL |
| 5 mM | 0.75 mL | 3.76 mL | 7.53 mL |
| 10 mM | 0.38 mL | 1.88 mL | 3.76 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.75 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kerr 2-Hydroxysaclofen: an improved antagonist at central and peripheral GABAB receptors. Neurosci.Lett. 1988 PMID: 2847092
- Curtis Baclofen antagonism by 2-hydroxysaclofen in the cat spinal cord. Neurosci.Lett. 1988 PMID: 2847093
Product Specific Notices for 2-Hydroxysaclofen
For research use only
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