SCH 50911

Name: SCH 50911
Brand: Tocris Bioscience
SKU: 0984

Catalog # 0984 | Tocris Bioscience a Bio-Techne Brand

Citations (10)

COA / SDS

Selective and competitive GABAB antagonist; orally bioavailable

Key Product Details

Description:	Selective and competitive GABA_B antagonist; orally bioavailable
Chemical Name:	(2S)-(+)-5,5-Dimethyl-2-morpholineacetic acid
Purity:	≥98%
Molecular Weight:	173.21

View Full Technical Details for SCH 50911

Technical Data
Citations (10) / Reviews

Biological Activity for SCH 50911

SCH 50911 is a selective, competitive and orally active GABA_B antagonist. Displays an IC₅₀ of 1.1 μM at GABA_B, approximately 60 times that of CGP 35348 (Cat. No. 1245) and no binding affinity for GABA_A at concentrations up to 100 μM.

Licensing Information

Sold with the permission of Schering Plough Corporation

Technical Data for SCH 50911

M. Wt	173.21
Formula	C₈H₁₅NO₃
Storage	Desiccate at -20°C
Purity	≥98%
CAS Number	733717-87-8
PubChem ID	5311429
InChi Key	SEYCKMQSPUVYEF-LURJTMIESA-N
Smiles	[H][C@]1(CC(O)=O)CNC(C)(C)CO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SCH 50911

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	17.32	100
	phosphate buffered saline	17.32	100

Preparing Stock Solutions for SCH 50911

The following data is based on the product molecular weight 173.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.77 mL	28.87 mL	57.73 mL
5 mM	1.15 mL	5.77 mL	11.55 mL
10 mM	0.58 mL	2.89 mL	5.77 mL
50 mM	0.12 mL	0.58 mL	1.15 mL

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Reconstitution Calculator

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References for SCH 50911

References are publications that support the biological activity of the product.

Ong The morpholino-acetic acid analogue Sch 50911 is a selective GABA_B receptor antagonist in rat neocortical slices. Eur.J.Pharmacol. 1998 PMID: 9865527
Blythin Substituted morpholine-2S-acetic acid derivatives: SCH 50911 and related compounds as novel GABA_B antagonists. Bioorg.Med.Chem.Lett.
Bolser The pharmacology of SCH 50911: a novel, orally active GABA-B receptor antagonist. J.Pharmacol.Exp.Ther. 1995 PMID: 7562513
Hosford Characterization of the antiabsence effects of SCH 50911, a GABA_B receptor antagonist, in the lethargic mouse, γ-hydroxybutyrate, and pentylenetetrazole models. J.Pharmacol. Exp.Ther. 1995 PMID: 7562514

Citations for SCH 50911 (10)

Showing 1 - 10 of 10 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for SCH 50911 include:

Kreye et al. (2016) Human cerebrospinal fluid monoclonal N-MthD.-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis. Brain. 139:2641
PMID: 27543972
Yu et al. (2016) Dentate cannabinoid-sensitive interneurons undergo unique and selective strengthening of mutual synaptic inhibition in experimental epilepsy. Neurobiol Dis. 89:23
PMID: 26804027
Jaiswal et al. (2015) Reduction in focal ictal activity following transplantation of MGE interneurons requires expression of the GABAA receptor α4 subunit. J Psychopharmacol. 9:127
PMID: 25914623
Ding et al. (2015) The reinforcing effects of ethanol within the nucleus accumbens shell involve activation of local GABA and serotonin receptors. Br J Pharmacol. 29:725
PMID: 25922425
Kitagawa et al. (2009) Prediction and validation of a mechanism to control the threshold for inhibitory synaptic plasticity. Mol Syst Biol. 5:280
PMID: 19536203
Fritsch et al. (2009) Pathological alterations in GABAergic interneurons and reduced tonic inhibition in the basolateral amygdala during epileptogenesis. Neuroscience. 163:415
PMID: 19540312
Gryder et al. (2005) Evidence for low GluR2 AMPA receptor subunit expression at synapses in the rat basolateral amygdala. Toxins (Basel). 94:1728
PMID: 16045445
Margeta-Mitrovic et al. (2001) Ligand-induced signal transduction within heterodimeric GABA(B) receptor. Front Cell Neurosci. 98:14643
PMID: 11724957
Wood et al. (2000) The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. J Neurochem. 131:1050
PMID: 11082110
Vogt and Nicoll (1999) Glutamate and gamma-aminobutyric acid mediate a heterosynaptic depression at mossy fiber synapses in the hippocampus. Proc Natl Acad Sci U S A. 96:1118
PMID: 9927703

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