CGP 35348

Name: CGP 35348
Brand: Tocris Bioscience
SKU: 1245

Tocris Bioscience, part of Bio-Techne | Catalog # 1245

Citations (114)

COA / SDS

Selective GABAB antagonist; brain penetrant

Key Product Details

Description:	Selective GABA_B antagonist; brain penetrant
Chemical Name:	(3-Aminopropyl)(diethoxymethyl)phosphinic acid
Molecular Weight:	225.22

View Full Technical Details for CGP 35348

Technical Data
Citations

Biological Activity for CGP 35348

CGP 35348 is a selective, brain penetrant GABA_B receptor antagonist (IC₅₀ = 34 μM as measured in rat cortical membranes). Has higher affinity for postsynaptic versus presynaptic receptors.

Licensing Information

Sold with the permission of Novartis Pharma AG

Technical Data for CGP 35348

M. Wt	225.22
Formula	C₈H₂₀NO₄P
Storage	Store at RT
CAS Number	123690-79-9
PubChem ID	107699
InChi Key	QIIVUOWTHWIXFO-UHFFFAOYSA-N
Smiles	NCCCP(C(OCC)OCC)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CGP 35348

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions for CGP 35348

The following data is based on the product molecular weight 225.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.44 mL	22.20 mL	44.40 mL
5 mM	0.89 mL	4.44 mL	8.88 mL
10 mM	0.44 mL	2.22 mL	4.44 mL
50 mM	0.09 mL	0.44 mL	0.89 mL

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Reconstitution Calculator

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References for CGP 35348

References are publications that support the biological activity of the product.

Sutor and Luhmann Involvement of GABA_B receptors in convulsant-induced epileptiform activity in rat neocortex in vitro. Eur.J.Neurosci. 1998 PMID: 9824455
Olpe CGP 35348: a centrally active blocker of GABA_B receptors. Eur.J.Pharmacol. 1990 PMID: 2176979
Staubli GABA_B receptor antagonism: facilitatory effects on memory parallel those on LTP induced by TBS but not HFS. J.Neurosci. 1999 PMID: 10341258
Hao Intrathecal γ-aminobutyric acid_B (GABA_B) receptor antagonist CGP 35348 induces hypersensitisation to mechanical stimuli in the rat. Neurosci.Lett. 1994 PMID: 7715832