CGP 36216 hydrochloride

Name: CGP 36216 hydrochloride
Brand: Tocris Bioscience
SKU: 3219

Tocris Bioscience a Bio-Techne Brand

Catalog # 3219

Citations (1)

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Key Product Details

Description:	GABA_B antagonist; displays activity at presynaptic receptors
Chemical Name:	(3-Aminopropyl)ethylphosphinic acid hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	187.6

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Biological Activity for CGP 36216 hydrochloride

CGP 36216 hydrochloride is a selective GABA_B antagonist. Displays activity at presynaptic receptors; ineffective at GABA_B postsynaptic receptors.

Compound Libraries for CGP 36216 hydrochloride

CGP 36216 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CGP 36216 hydrochloride

M. Wt	187.6
Formula	C₅H₁₄NO₂P.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	1781834-71-6
PubChem ID	90488815
InChi Key	CFQFXUJBWMPODB-UHFFFAOYSA-N
Smiles	O=P(CC)(CCCN)O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CGP 36216 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	18.76	100
	DMSO	18.76	100

Preparing Stock Solutions for CGP 36216 hydrochloride

The following data is based on the product molecular weight 187.6.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.33 mL	26.65 mL	53.30 mL
5 mM	1.07 mL	5.33 mL	10.66 mL
10 mM	0.53 mL	2.67 mL	5.33 mL
50 mM	0.11 mL	0.53 mL	1.07 mL

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References for CGP 36216 hydrochloride

References are publications that support the biological activity of the product.

Ong CGP 36216 is a selective antagonist at GABA_B presynaptic receptors in rat brain. Eur.J.Pharmacol. 2001 PMID: 11274998
Froestl Phosphinic acid analogues of GABA. 2. Selective, orally active GABA_B antagonists. J.Med.Chem. 1995 PMID: 7650685

Citations for CGP 36216 hydrochloride (1)

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Citations are publications that use Bio-Techne products. Selected citations for CGP 36216 hydrochloride include:

Chen et al. (2015) Morphine disinhibits glutamatergic input to VTA DA neurons and promotes DA neuron excitation. J Neurosci. 4
PMID: 26208338

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Product Documents for CGP 36216 hydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.