CGP 54626 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 1088
Potent and selective GABAB antagonist
Key Product Details
Description
Potent and selective GABAB antagonist
Product Description
CGP 54626 hydrochloride is a potent, selective GABAB receptor antagonist (IC50 = 4 nM).Licensing Information
Sold with the permission of Novartis Pharma AGProduct Specifications
Molecular Weight
444.76
Formula
C18H28Cl2NO3P.HCl
Storage
Store at RT
Purity
≥96% (HPLC)
Chemical Name
[S-(R*,R*)]-[3-[[1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](cyclohexylmethyl) phosphinic acid
CAS Number
149184-21-4
PubChem ID
197583
InChI Key
ZQCFHOVIXCJPLE-LINSIKMZSA-N
SMILES
OP(CC1CCCCC1)(C[C@@H](O)CN[C@@H](C)C2=CC(Cl)=C(Cl)C=C2)=O.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 22.24 | 50 | |
| Ethanol | 4.45 | 10 with gentle warming |
Preparing Stock Solutions
for CGP 54626 hydrochloride
The following data is based on the product molecular weight 444.76
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.50 mL | 22.48 mL | 44.97 mL |
| 2.5 mM | 0.90 mL | 4.50 mL | 8.99 mL |
| 5 mM | 0.45 mL | 2.25 mL | 4.50 mL |
| 25 mM | 0.09 mL | 0.45 mL | 0.90 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kaupmann GABAB-receptor subtypes assemble into functional heteromeric complexes. Nature 1998 PMID: 9872317
- Froestl Potent, orally active GABAB receptor antagonists. Pharmacol.Rev.Comm.
- Brugger The action of new potent GABAB receptor antagonists in the hemisected spinal cord preparation of the rat. Eur.J.Pharmacol. 1993 PMID: 8390938
Product Specific Notices for CGP 54626 hydrochloride
For research use only
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