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Key Product Details
Description: | Selective GABAB agonist |
Chemical Name: | (RS)-4-Amino-3-(4-chlorophenyl)butanoic acid |
Purity: | ≥99% (HPLC) |
Molecular Weight: | 213.66 |
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Citations (23)
Citations are publications that use Bio-Techne products. Selected citations for (RS)-Baclofen include:
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Limó n et al.
(2019)
Electrophysiological evaluation of extracellular spermine and alkaline pH on synaptic human GABAA receptors.
Transl Psychiatry.
9:218
PMID: 31488811 -
Vergassola et al.
(2018)
Presynaptic mGlu1 Receptors Control GABAB Receptors in an Antagonist-Like Manner in Mouse Cortical GABAergic and Glutamatergic Nerve Endings.
Front Mol Neurosci.
11:324
PMID: 30279647 -
Doshina et al.
(2017)
Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission.
Sci Rep.
7:370
PMID: 28337033 -
Yu et al.
(2016)
Dentate cannabinoid-sensitive interneurons undergo unique and selective strengthening of mutual synaptic inhibition in experimental epilepsy.
Neurobiol Dis.
89:23
PMID: 26804027 -
Terunuma et al.
(2015)
Purinergic receptor activation facilitates astrocytic GABAB receptor calcium signalling.
Front Cell Neurosci.
88:74
PMID: 25261019 -
Baquero et al.
(2015)
Developmental changes in synaptic distribution in arcuate nucleus neurons.
Neuropsychopharmacology.
35:8558
PMID: 26041922 -
Bell et al.
(2015)
Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation.
J Neurophysiol.
9:115
PMID: 25918499 -
Rubio et al.
(2015)
Context-induced reinstatement of metha. seeking is associated with unique molecular alterations in Fos-expressing dorsolateral striatum neurons.
J Neurosci.
35:5625
PMID: 25855177 -
Chen et al.
(2014)
Prolonged adenosine A1 receptor activation in hypoxia and pial vessel disruption focal cortical ischemia facilitates clathrin-mediated AMPA receptor endocytosis and long-lasting synaptic inhibition in rat hippocampal CA3-CA1 synapses: differential regulat
J Neurosci.
34:9621
PMID: 25031403 -
Kerkhof et al.
(2013)
Social play behavior in adolescent rats is mediated by functional activity in medial prefrontal cortex and striatum.
Neuropsychopharmacology.
38:1899
PMID: 23568326 -
Wojnicki et al.
(2013)
Baclofen-induced reductions in optional food intake depend upon food composition.
Appetite.
64:62
PMID: 23321345 -
Zemoura et al.
(2013)
Endoplasmic reticulum-associated degradation controls cell surface expression of γ-aminobutyric acid, type B receptors.
J Biol Chem.
288:34897
PMID: 24114844 -
Yang et al.
(2013)
PropF. inhibits superoxide production, elastase release, and chemotaxis in formyl peptide-activated human neutrophils by blocking formyl peptide receptor 1.
J Immunol.
190:6511
PMID: 23670191 -
Baloucoune et al.
(2012)
GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation.
PLoS One.
7:e39698
PMID: 22761875 -
Won et al.
(2011)
Identification and modulation of voltage-gated Ca2+ currents in zebrafish Rohon-Beard neurons.
J Neurophysiol.
105:442
PMID: 20962070 -
Takesian et al.
(2010)
Presynaptic GABA(B) receptors regulate experience-dependent development of inhibitory short-term plasticity.
J Neurosci.
30:2716
PMID: 20164356 -
Olmos-Serrano et al.
(2010)
Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome.
Neuropharmacology.
30:9929
PMID: 20660275 -
Tu et al.
(2010)
GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation.
J Neurosci.
30:749
PMID: 20071540 -
Bray and Mynlieff
(2009)
Influx of calcium through L-type calcium channels in early postnatal regulation of chloride transporters in the rat hippocampus.
Dev Neurobiol.
69:885
PMID: 19777558 -
Petzold et al.
(2008)
Coupling of neural activity to blood flow in olfactory glomeruli is mediated by astrocytic pathways.
J Neurosci.
58:897
PMID: 18579080 -
Maher and Westbrook
(2008)
Co-transmission of DA and GABA in periglomerular cells.
J Neurosci.
99:1559
PMID: 18216231 -
Miyazato et al.
(2008)
GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats.
J Urol.
179:1178
PMID: 18206170 -
Jakubs et al.
(2006)
Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability.
Neuron.
52:1047
PMID: 17178407
There are no citations that match your criteria.
Customer Reviews (1)
Customer Images
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Species: MouseAssay Type: Ex VivoEffects of GABAB agonism on electrically stimulated dopamine release was measured using fast scan cyclic voltammetry. Baclofen (30uM) was bath applied. This is a maximal concentration.Effect was pretty small on striatal dopamine release. This may be due to low expression on terminals.
There are no reviews that match your criteria.