(R)-Baclofen

Name: ( R )-Baclofen
Brand: Tocris Bioscience
SKU: 0796
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0796

(1)

Citations (85)

COA / SDS

Selective GABAB agonist; active enantiomer of (RS)-Baclofen (Cat. No. 0417)

Key Product Details

Description:	Selective GABA_B agonist; active enantiomer of (RS)-Baclofen (Cat. No. 0417)
Alternative Names:	STX 209
Chemical Name:	(R)-4-Amino-3-(4-chlorophenyl)butanoic acid
Purity:	≥99% (HPLC)
Molecular Weight:	213.66

View Full Technical Details for (R)-Baclofen

Technical Data
Citations / Reviews (1)

Biological Activity for (R)-Baclofen

More active enantiomer of (RS)-Baclofen, a selective GABA_B agonist.

Racemate also available.

Technical Data for (R)-Baclofen

M. Wt	213.66
Formula	C₁₀H₁₂ClNO₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	69308-37-8
PubChem ID	44602
InChi Key	KPYSYYIEGFHWSV-QMMMGPOBSA-N
Smiles	NC[C@@](CC(O)=O)([H])C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (R)-Baclofen

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	4.27	20 with gentle warming

Preparing Stock Solutions for (R)-Baclofen

The following data is based on the product molecular weight 213.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	23.40 mL	117.01 mL	234.02 mL
1 mM	4.68 mL	23.40 mL	46.80 mL
2 mM	2.34 mL	11.70 mL	23.40 mL
10 mM	0.47 mL	2.34 mL	4.68 mL

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Reconstitution Calculator

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References for (R)-Baclofen

References are publications that support the biological activity of the product.

Hong Effects of phaclofen and the enantiomers of bac. on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat. Eur.J.Pharmacol. 1991 PMID: 1654254
Falch Comparative stereostructure-activity studies on GABA_A and GABA_B receptor sites and GABA uptake using rat brain membrane preparations. J.Neurochem. 1986 PMID: 3016189