Key Product Details
Description: | Selective GABAB agonist; active enantiomer of (RS)-Baclofen (Cat. No. 0417) |
Alternative Names: | STX 209 |
Chemical Name: | (R)-4-Amino-3-(4-chlorophenyl)butanoic acid |
Purity: | ≥99% (HPLC) |
Molecular Weight: | 213.66 |
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Citations for (R)-Baclofen (14)
Citations are publications that use Bio-Techne products. Selected citations for (R)-Baclofen include:
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Styr et al.
(2019)
Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility.
Neuron.
102:1009
PMID: 31047779 -
Chai et al.
(2017)
Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.
Neuron.
95:531
PMID: 28712653 -
Bragina et al.
(2015)
Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals.
Front Cell Neurosci.
9:345
PMID: 26388733 -
Kirwan et al.
(2015)
Development and function of human cerebral cortex neural networks from pluripotent stem cells in vitro.
J Pharmacol Exp Ther.
142:3178
PMID: 26395144 -
Zhang et al.
(2015)
GABAB receptor upregulates fragile X mental retardation protein expression in neurons.
Front Cell Neurosci.
5:10468
PMID: 26020477 -
Wang et al.
(2015)
Neuronal γ-aminobutyric acid (GABA) type A receptors undergo cognate ligand chaperoning in the endoplasmic reticulum by endogenous GABA.
Mol Cell Neurosci.
9:188
PMID: 26041994 -
Xia et al.
(2014)
Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons.
PLoS One.
9:e100968
PMID: 24971996 -
Hensler et al.
(2012)
GABAB receptor-positive modulators: brain region-dependent effects.
J Pharmacol Exp Ther.
340:19
PMID: 21954301 -
Messer and Levine
(2012)
Epileptiform activity in the CA1 region of the hippocampus becomes refractory to attenuation by cannabinoids in part because of endogenous γ-aminobutyric acid type B receptor activity.
J Neurosci Res.
90:1454
PMID: 22388975 -
Klug et al.
(2012)
Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability.
PLoS One.
7:e45323
PMID: 23028932 -
Pacey et al.
(2011)
Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome.
Sci Rep.
338:897
PMID: 21636656 -
Lobb et al.
(2010)
A dynamic role for GABA receptors on the firing pattern of midbrain DArgic neurons.
J Neurophysiol.
104:403
PMID: 20445035 -
Bartoi et al.
(2010)
GABAB receptor constituents revealed by tandem affinity purification from transgenic mice.
J Biol Chem.
285:20625
PMID: 20406808 -
Piqueras and Martínez
(2004)
Peripheral GABAB agonists stimulate gastric acid secretion in mice.
Br J Pharmacol.
142:1038
PMID: 15210585
There are no citations that match your criteria.
Customer Reviews for (R)-Baclofen (1)
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Species: MouseAssay Type: Ex VivoUsed to activate GABAb, direct application. Although it did not trigger any response, neither did GABA and this was expected, used it to confirm GABAb is not involved in our assay.
There are no reviews that match your criteria.