CGP 52432

Name: CGP 52432
Brand: Tocris Bioscience
SKU: 1246
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1246

(1)

Citations (174)

COA / SDS

Potent and selective GABAB antagonist

Key Product Details

Description:	Potent and selective GABA_B antagonist
Chemical Name:	3-[[(3,4-Dichlorophenyl)methyl]amino]propyl] diethoxymethyl)phosphinic acid
Purity:	≥98% (HPLC)
Molecular Weight:	384.24

View Full Technical Details for CGP 52432

Technical Data
Citations / Reviews (1)

Biological Activity for CGP 52432

CGP 52432 is a potent, selective GABA_B receptor antagonist (IC₅₀ = 85 nM).

Licensing Information

Sold with the permission of Novartis Pharma AG

Technical Data for CGP 52432

M. Wt	384.24
Formula	C₁₅H₂₄Cl₂NO₄P
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	139667-74-6
PubChem ID	132252
InChi Key	GJZVQXWEIYRHBE-UHFFFAOYSA-N
Smiles	ClC1=CC=C(CNCCCP(C(OCC)OCC)(O)=O)C=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CGP 52432

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	1.92	5

Preparing Stock Solutions for CGP 52432

The following data is based on the product molecular weight 384.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	52.05 mL	260.25 mL	520.51 mL
0.25 mM	10.41 mL	52.05 mL	104.10 mL
0.5 mM	5.21 mL	26.03 mL	52.05 mL
2.5 mM	1.04 mL	5.21 mL	10.41 mL

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Reconstitution Calculator

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References for CGP 52432

References are publications that support the biological activity of the product.

Froestl Potent, orally active GABA_B receptor antagonists. Pharmacol.Rev.Comm.
Lanza CGP 52432: a novel potent and selective GABA_B autoreceptor antagonist in rat cerebral cortex. Eur.J.Pharmacol. 1993 PMID: 8103461
Libri Blockade of GABA_B receptors facilitates muscarinic agonist-induced epileptiform activity in immature rat piriform cortex in vitro. Naunyn Schmiedebergs Arch.Pharmacol. 1998 PMID: 9750001
Bonanno GABA_B receptors as potential targets for drugs able to prevent excessive excitatory amino acid transmission in the spinal cord. Eur.J.Pharmacol. 1998 PMID: 9874164