rac BHFF
Tocris Bioscience, part of Bio-Techne | Catalog # 3313
Potent and selective postitive allosteric modulator of GABAB receptors
Key Product Details
Description
Potent and selective postitive allosteric modulator of GABAB receptors
Product Description
rac BHFF is a potent and selective GABAB receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149% respectively). Exhibits anxiolytic activity in vivo and is orally active.Product Specifications
Molecular Weight
330.34
Formula
C17H21F3O3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
5,7-Bis(1,1-dimethylethyl)-3-hydroxy-3(trifluoromethyl)-2(3H)-benzofuranone
CAS Number
123557-91-5
PubChem ID
4332683
InChI Key
RVNOANDLZIIFHB-UHFFFAOYSA-N
SMILES
CC(C)(C)C1=C2C(C(O)(C(F)(F)F)C(O2)=O)=CC(C(C)(C)C)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.03 | 100 | |
| Ethanol | 33.03 | 100 |
Preparing Stock Solutions
for rac BHFF
The following data is based on the product molecular weight 330.34
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.03 mL | 15.14 mL | 30.27 mL |
| 5 mM | 0.61 mL | 3.03 mL | 6.05 mL |
| 10 mM | 0.30 mL | 1.51 mL | 3.03 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.61 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Koek Discriminative stimulus effects of the GABAB receptor-positive modulator rac-BHFF: comparison with GABAB receptor agonists and drugs of abuse. J.Pharmacol.Exp.Ther. 2013 PMID: 23275067
- Malherbe Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors. Br.J.Pharmacol. 2008 PMID: 18536733
Product Specific Notices for rac BHFF
For research use only
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