beta-2 Adrenergic R/ADRB2: Small Molecules and Peptides
ADRB2 is a member of the G protein-coupled receptor superfamily that is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. ADRB2 binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by ADRB2. Different polymorphic forms, point mutations, and/or downregulation of ADRB2 are associated with nocturnal asthma, obesity and type 2 diabetes.
14 results for "beta-2 Adrenergic R/ADRB2 Small Molecules and Peptides" in Products
14 results for "beta-2 Adrenergic R/ADRB2 Small Molecules and Peptides" in Products
beta-2 Adrenergic R/ADRB2: Small Molecules and Peptides
ADRB2 is a member of the G protein-coupled receptor superfamily that is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. ADRB2 binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by ADRB2. Different polymorphic forms, point mutations, and/or downregulation of ADRB2 are associated with nocturnal asthma, obesity and type 2 diabetes.
Highly selective β2 inverse agonist
| Chemical Name: | (±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride |
| Purity: | ≥98% (HPLC) |
Standard selective β agonist
| Alternate Names: | Isoprenaline |
| Chemical Name: | 4-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]-1,2-benzenediol hydrochloride |
| Purity: | ≥98% (HPLC) |
α1, β1 and β2 agonist
| Chemical Name: | 4-[2-[[3-(4-Hydroxyphenyl)-1-methylpropyl]aminoethyl-1,2-benzenediol hydrochloride |
| Purity: | ≥98% (HPLC) |
β antagonist
| Chemical Name: | (RS)-1-[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol hydrochloride |
Non-selective 5-HT, dopamine, adrenalin and histamine receptor antagonist; antipsychotic agent
| Chemical Name: | (3aR*,12bR*)-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate |
| Purity: | ≥98% (HPLC) |
β2-adrenoceptor agonist
| Alternate Names: | Albuterol |
| Chemical Name: | α1-[[(1,1-Dimethylethyl)amino]methyl]-4-hydroxy-1,3-benzenedimethanol hemisulfate |
| Purity: | ≥98% (HPLC) |
5-HT1A and 5-HT1B antagonist; also β-adrenergic antagonist
| Chemical Name: | 4-[3-[tert-Butylamino]-2-hydroxypropoxy]-1H-indole-2-carbonitrile hemifumarate |
| Purity: | ≥98% (HPLC) |
Long-acting β2 agonist; bronchodilator
| Chemical Name: | 4-Hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol 1-hydroxy-2-naphthalenecarboxylic acid salt |
| Purity: | ≥98% (HPLC) |
Potent and non-selective β antagonist; also potent α1 antagonist
| Alternate Names: | BM 14190 |
| Chemical Name: | 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol |
| Purity: | ≥98% (HPLC) |
β3 partial agonist. β1/β2 antagonist
| Chemical Name: | 4-[3-[(1,1-Dimethylethyl)amino]2-hydroxypropoxy]-1,3-dihydro-2H-benzimidazol-2-one hydrochloride |
Potent β2 agonist
| Chemical Name: | (±)-erythro-8-Hydroxy-5-[1-hydroxy-2-(isopropylamino)butyl]carbostyril hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent 5-HT2 antagonist; also 5-HT3, H1 and α2 antagonist; antidepressant
| Alternate Names: | Org 3770,6-Azamianserin |
| Chemical Name: | 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine |
| Purity: | ≥98% (HPLC) |
Long-acting β2 agonist (LABA)
| Chemical Name: | N-[2-Hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide L-tartrate |
| Purity: | ≥98% (HPLC) |
Potent and selective β2 agonist
| Alternate Names: | BD 40A |
| Chemical Name: | (±)-(R,R)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl] formamide hemifumarate |
| Purity: | ≥98% (HPLC) |
