Propranolol hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 0624
β antagonist
Key Product Details
Description
β antagonist
Product Description
Propranolol hydrochloride is an β-adrenergic antagonist.R-enantiomer, S-enantiomer and Glycol Metabolite also available.
Scientific Data Images for Propranolol hydrochloride
Small molecules affect the rate of cardiomyocyte contraction.
Cardiomyocytes were differentiated from the BG01V human embryonic stem cells and assessed for their ability to contract using the Fluo-4 calcium binding assay. Rate interval graph show fluctuations in Fluo-4 fluorescence intensity, indicative of cardiomyocyte contraction, under basal conditions (brown; untreated) and following sequential treatment with Isoproterenol (blue; Catalog # 1747), a beta-adrenergic agonist, and Propranolol (tan; Catalog # 0624), a beta-adrenergic antagonist. Table shows drug concentrations and contraction rate of cardiomyocytes during each treatment. The contraction rate of differentiated cardiomyocytes was determined as the number of contractions (contraction-interval plus relaxation interval) per minute.Product Specifications
Molecular Weight
295.81
Formula
C16H21NO2.HCl
Storage
Store at RT
Chemical Name
(RS)-1-[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol hydrochloride
CAS Number
318-98-9
PubChem ID
62882
InChI Key
ZMRUPTIKESYGQW-UHFFFAOYSA-N
SMILES
Cl.CC(C)NCC(O)COC1=C2C=CC=CC2=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 29.58 | 100 |
Preparing Stock Solutions
for Propranolol hydrochloride
The following data is based on the product molecular weight 295.81
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.38 mL | 16.90 mL | 33.81 mL |
| 5 mM | 0.68 mL | 3.38 mL | 6.76 mL |
| 10 mM | 0.34 mL | 1.69 mL | 3.38 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Xie The inhibitory effect of propra. on ATP-sensitive potassium channels in neonatal rat heart. Br.J.Pharmacol. 1998 PMID: 9517376
- Litwin Effects of propra. treatment on left ventricular function and intracellular calcium regulation in rats with postinfarction heart failure. Br.J.Pharmacol. 1999 PMID: 10455325
Product Specific Notices for Propranolol hydrochloride
For research use only
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