Formoterol hemifumarate
Tocris Bioscience, part of Bio-Techne | Catalog # 1448
Potent and selective β2 agonist
Key Product Details
Description
Potent and selective β2 agonist
Alternative Names
BD 40A
Product Description
Formoterol hemifumarate is a potent, selective and long-acting β2-adrenoceptor agonist. Displays 330-fold selectivity for β2 over β1 receptors (pKd values are 8.12 and 5.58 respectively). Potently relaxes guinea pig trachea (pD2 = 9.29), and is longer-acting and 100-fold more potent than Salbutamol (Cat. No. 0634).Product Specifications
Molecular Weight
402.45
Formula
C19H24N2O4.½C4H4O4
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(±)-(R,R)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl] formamide hemifumarate
CAS Number
43229-80-7
PubChem ID
9832292
InChI Key
OBRNDARFFFHCGE-PERKLWIXSA-N
SMILES
[H]OC(=O)\C=C\C(=O)O[H].COC1=CC=C(C=C1)C[C@H](C)NC[C@@H](O)C1=CC(NC([H])=O)=C(O)C=C1.COC1=CC=C(C=C1)C[C@H](C)NC[C@@H](O)C1=CC(NC([H])=O)=C(O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50 |
Preparing Stock Solutions
for Formoterol hemifumarate
The following data is based on the product molecular weight 402.45
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.97 mL | 24.85 mL | 49.70 mL |
| 2.5 mM | 0.99 mL | 4.97 mL | 9.94 mL |
| 5 mM | 0.50 mL | 2.48 mL | 4.97 mL |
| 25 mM | 0.10 mL | 0.50 mL | 0.99 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Decker Effects of N-aralkyl substitution of β-agonists on α- and β-adrenoceptor subtypes: pharmacological studies and binding assays. J.Pharm.Pharmacol. 1982 PMID: 6121868
- Naline Relaxant effects and durations of action of formo. and salme. on the isolated human bronchus. Eur.Respir.J. 1994 PMID: 7914176
- Anderson Formoterol: pharmacology, molecular basis of agonism, and mechanism of long duration of a highly potent and selective β2-adrenoceptor agonist bronchodilator. Life Sci. 1993 PMID: 8099696
Product Specific Notices for Formoterol hemifumarate
For research use only
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