Salbutamol hemisulfate

Name: Salbutamol hemisulfate
Brand: Tocris Bioscience
SKU: 0634
Price: 176 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 0634

Citations (6)

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Key Product Details

Description:	β₂-adrenoceptor agonist
Alternative Names:	Albuterol
Chemical Name:	α¹-[[(1,1-Dimethylethyl)amino]methyl]-4-hydroxy-1,3-benzenedimethanol hemisulfate
Purity:	≥99% (HPLC)
Molecular Weight:	288.35

View Full Technical Details for Salbutamol hemisulfate

Biological Activity for Salbutamol hemisulfate

Salbutamol hemisulfate is a selective β₂-adrenergic agonist with 29-fold higher selectivity for β₂ over β₁ receptors. Salbutamol elevates fibroblast growth factor 20 (FGF20) in nigrostriatal neurons, and is neuroprotective in a mouse model of Parkinson's disease.

Technical Data for Salbutamol hemisulfate

M. Wt	288.35
Formula	C₁₃H₂₁NO₃.1/₂H₂SO₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	51022-70-9
PubChem ID	39859
InChi Key	BNPSSFBOAGDEEL-UHFFFAOYSA-N
Smiles	OS(O)(=O)=O.CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1.CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Salbutamol hemisulfate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	28.84	100

Preparing Stock Solutions for Salbutamol hemisulfate

The following data is based on the product molecular weight 288.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.47 mL	17.34 mL	34.68 mL
5 mM	0.69 mL	3.47 mL	6.94 mL
10 mM	0.35 mL	1.73 mL	3.47 mL
50 mM	0.07 mL	0.35 mL	0.69 mL

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References for Salbutamol hemisulfate

References are publications that support the biological activity of the product.

Fletcher Targeted repositioning identifies drugs that increase fibroblast growth factor 20 production and protect against 6-hydroxydopamine-induced nigral cell loss in rats. Sci.Rep. 2019 PMID: 31171821
Baker The selectivity of beta-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors. Br.J.Pharmacol. 2005 PMID: 15655528
January Salmeterol-induced desensitisation, internalization and phosphorylation of the human β₂-adrenoceptor. Br.J.Pharmacol. 1998 PMID: 9517390
Prior Effects of the enantiomers of R,S-salbutamol on incompletely fused tetanic contractions of slow- and fast-twitch skeletal muscles of the guinea-pig. Br.J.Pharmacol. 1998 PMID: 9504397
Strosberg and Pietri-Rouxel Function and regulation of the β₃-adrenoceptor. TiPS 1996 PMID: 8979772

Citations for Salbutamol hemisulfate (6)

Showing 1 - 6 of 6 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Salbutamol hemisulfate include:

Picard et al. (2018) Bioluminescence resonance energy transfer-based biosensors allow monitoring of ligand- and transducer-mediated GPCR conformational changes. Commun Biol. 1:106
PMID: 30271986
Namkung et al. (2016) Monitoring G protein-coupled receptor and [beta]-arrestin trafficking in live cells using enhanced bystander BRET Nature Communications. 7:12178
PMID: 27397672
Pon et al. (2016) The β2-adrenoceptor activates a positive cAMP-calcium feedforward loop to drive breast cancer cell invasion. FASEB J. 30:1144
PMID: 26578688
Zaytseva et al. (2013) Resonant waveguide grating biosensor-enabled label-free and fluorescence detection of cell adhesion. Sens Actuators B Chem. 188
PMID: 24319319
Sykes and Charlton (2012) Slow receptor dissociation is not a key factor in the duration of action of inhaled long-acting β2-adrenoceptor agonists. Br J Pharmacol. 165:2672
PMID: 21883146
Baker (2005) The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. Br.J.Pharmacol.. 144:317
PMID: 1565552

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Showing 1 - 6 of 6 citations Showing All

Product Documents for Salbutamol hemisulfate

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.