Salmeterol xinafoate
Tocris Bioscience, part of Bio-Techne | Catalog # 4712
Long-acting β2 agonist; bronchodilator
Key Product Details
Description
Long-acting β2 agonist; bronchodilator
Product Description
Salmeterol xinafoate is a long-acting β2 adrenergic receptor agonist. Inhibits the release of histamine, leukotrienes and prostaglandin D2, and blocks GM-CSF production from human cultured mast cells. Exhibits efficacious bronchodilatory activity in patients with asthma or chronic obstructive pulmonary disease (COPD).Product Specifications
Molecular Weight
603.75
Formula
C25H37NO4.C11H8O3
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
4-Hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol 1-hydroxy-2-naphthalenecarboxylic acid salt
CAS Number
94749-08-3
PubChem ID
56801
InChI Key
XTZNCVSCVHTPAI-UHFFFAOYSA-N
SMILES
OC(C2=CC(CO)=C(O)C=C2)CNCCCCCCOCCCCC1=CC=CC=C1.OC4=C(C(O)=O)C=CC3=CC=CC=C34
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 60.37 | 100 | |
| Ethanol | 12.07 | 20 |
Preparing Stock Solutions
for Salmeterol xinafoate
The following data is based on the product molecular weight 603.75
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.66 mL | 8.28 mL | 16.56 mL |
| 5 mM | 0.33 mL | 1.66 mL | 3.31 mL |
| 10 mM | 0.17 mL | 0.83 mL | 1.66 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.33 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Rennard Use of a long-acting inhaled beta2-adrenergic agonist, salme. xinafoate, in patients with chronic obstructive pulmonary disease. Am.J.Respir.Crit.Care Med. 2001 PMID: 11316640
- Roberts The long-acting beta2-agonist salme. xinafoate: effects on airway inflammation in asthma. Eur.Respir.J. 1999 PMID: 10515401
- Akabane Effects of salme. xinafoate and flutic. propionate on immunological activation of human cultured mast cells. Allergol.Int. 2006 PMID: 17130681
Product Specific Notices for Salmeterol xinafoate
For research use only
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