Procaterol hydrochloride

Name: Procaterol hydrochloride
Brand: Tocris Bioscience
SKU: 1102

Catalog # 1102

Citations (5)

COA / SDS

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Key Product Details

Description:	Potent β₂ agonist
Chemical Name:	(±)-erythro-8-Hydroxy-5-[1-hydroxy-2-(isopropylamino)butyl]carbostyril hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	326.82

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Biological Activity

Procaterol hydrochloride is a specific and very potent β₂ agonist.

Compound Libraries

Procaterol hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	326.82
Formula	C₁₆H₂₂N₂O₃.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	62929-91-3
PubChem ID	43091
InChi Key	AEQDBKHAAWUCMT-CVHDTDHSSA-N
Smiles	O=C1C=CC2=C(C(O)=CC=C2[C@@]([H])(O)[C@@](NC(C)C)(CC)[H])N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	32.68	100
	DMSO	32.68	100

Preparing Stock Solutions

The following data is based on the product molecular weight 326.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.06 mL	15.30 mL	30.60 mL
5 mM	0.61 mL	3.06 mL	6.12 mL
10 mM	0.31 mL	1.53 mL	3.06 mL
50 mM	0.06 mL	0.31 mL	0.61 mL

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References

References are publications that support the biological activity of the product.

Kotsonis and Majewski Facilitation by procaterol, a β-adrenoceptor agonist, of noradrenaline release in the pithed rat independently of angiotensin II formation. Br.J.Pharmacol. 1994 PMID: 7858867
Lakhlani Pharmacological characterization and anatomical localization of prejunctional β-adrenoceptors in the rat kidney. Br.J.Pharmacol. 1994 PMID: 8032617
Yoshizaki Isomers of erythro-5-(1-hydroxy-2-isoproylaminobutyl)-8-hydroxycarbostyril, a new bronchodilator. J.Med.Chem. 1977 PMID: 894683
Yoshizaki Sympathomimetic amines having a carbostyril nucleus. J.Med.Chem. 1976 PMID: 10441

Citations for Procaterol hydrochloride (5)

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Citations are publications that use Bio-Techne products. Selected citations for Procaterol hydrochloride include:

Copik et al. (2015) Isoproterenol acts as a biased agonist of the α-1A-adrenoceptor that selectively activates the MAPK/ERK pathway. PLoS Med. 10:e0115701
PMID: 25606852
Rieg et al. (2012) Cardiovascular agents affect the tone of pulmonary arteries and veins in precision-cut lung slices. PLoS One. 6:e29698
PMID: 22216346
Schutsky et al. (2011) Stress and glucocorticoids impair memory retrieval via β2-adrenergic, Gi/o-coupled suppression of cAMP signaling. J Neurosci. 31:14172
PMID: 21976502
Sivamani et al. (2009) Stress-mediated increases in systemic and local epinephrine impair skin wound healing: potential new indication for β blockers. J Pharmacol Exp Ther. 6:e12
PMID: 19143471
Kaya et al. (2009) Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation. Front Cell Neurosci. 329:350
PMID: 19144685

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