Cyanopindolol hemifumarate
Tocris Bioscience, part of Bio-Techne | Catalog # 0993
5-HT1A and 5-HT1B antagonist; also β-adrenergic antagonist
Key Product Details
Description
5-HT1A and 5-HT1B antagonist; also β-adrenergic antagonist
Product Description
Cyanopindolol hemifumarate is a 5-HT1A/1B antagonist with roughly equal affinity at each receptor; also a β-adrenoceptor antagonist.Product Specifications
Molecular Weight
345.40
Formula
C16H21N3O2.½C4H4O4
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
4-[3-[tert-Butylamino]-2-hydroxypropoxy]-1H-indole-2-carbonitrile hemifumarate
CAS Number
69906-86-1
PubChem ID
45073413
InChI Key
ZSBITJKBOWVCCI-WXXKFALUSA-N
SMILES
[H]OC(=O)\C=C\C(=O)O[H].CC(C)(C)NCC(O)COC1=C2C=C(NC2=CC=C1)C#N.CC(C)(C)NCC(O)COC1=C2C=C(NC2=CC=C1)C#N
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.54 | 100 |
Preparing Stock Solutions
for Cyanopindolol hemifumarate
The following data is based on the product molecular weight 345.40
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.90 mL | 14.48 mL | 28.95 mL |
| 5 mM | 0.58 mL | 2.90 mL | 5.79 mL |
| 10 mM | 0.29 mL | 1.45 mL | 2.90 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Blue Interaction of dihydroalprenolol and cyanopindolol with atypical β-adrenoceptors in guinea-pig ileum. Br.J.Pharmacol.
- Giles Characterization of a 5-HT1B receptor on CHO cells: functional responses in the absence of radioligand binding. Br.J.Pharmacol. 1996 PMID: 8882605
- Hoey Atypical responses of rat ileum to pindolol, cyanopindolol and iodocyanopindolol. Br.J.Pharmacol. 1996 PMID: 8646418
- Engel Identity of presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites. Naunyn Schmiedebergs Arch.Pharmacol. 1986 PMID: 2936965
Product Specific Notices for Cyanopindolol hemifumarate
For research use only
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