Cyanopindolol hemifumarate

Name: Cyanopindolol hemifumarate
Brand: Tocris Bioscience
SKU: 0993

Catalog # 0993

Citations (4)

COA / SDS

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Key Product Details

Description:	5-HT_1A and 5-HT_1B antagonist; also β-adrenergic antagonist
Chemical Name:	4-[3-[tert-Butylamino]-2-hydroxypropoxy]-1H-indole-2-carbonitrile hemifumarate
Purity:	≥98% (HPLC)
Molecular Weight:	345.4

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Biological Activity

Cyanopindolol hemifumarate is a 5-HT_1A/1B antagonist with roughly equal affinity at each receptor; also a β-adrenoceptor antagonist.

Compound Libraries

Cyanopindolol hemifumarate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	345.4
Formula	C₁₆H₂₁N₃O₂.½C₄H₄O₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	69906-86-1
PubChem ID	45073413
InChi Key	ZSBITJKBOWVCCI-WXXKFALUSA-N
Smiles	[H]OC(=O)\C=C\C(=O)O[H].CC(C)(C)NCC(O)COC1=C2C=C(NC2=CC=C1)C#N.CC(C)(C)NCC(O)COC1=C2C=C(NC2=CC=C1)C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	34.54	100

Preparing Stock Solutions

The following data is based on the product molecular weight 345.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.90 mL	14.48 mL	28.95 mL
5 mM	0.58 mL	2.90 mL	5.79 mL
10 mM	0.29 mL	1.45 mL	2.90 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

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References

References are publications that support the biological activity of the product.

Hoey Atypical responses of rat ileum to pindolol, cyanopindolol and iodocyanopindolol. Br.J.Pharmacol. 1996 PMID: 8646418
Giles Characterization of a 5-HT_1B receptor on CHO cells: functional responses in the absence of radioligand binding. Br.J.Pharmacol. 1996 PMID: 8882605
Blue Interaction of dihydroalprenolol and cyanopindolol with atypical β-adrenoceptors in guinea-pig ileum. Br.J.Pharmacol.
Engel Identity of presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1_B binding sites. Naunyn Schmiedebergs Arch.Pharmacol. 1986 PMID: 2936965

Citations for Cyanopindolol hemifumarate (4)

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Citations are publications that use Bio-Techne products. Selected citations for Cyanopindolol hemifumarate include:

Gautam et al. (2016) Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling. Mol Cancer. 15:75
PMID: 27871326
Kaya et al. (2009) Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation. J Pharmacol Exp Ther. 329:350
PMID: 19144685
Brahmadevara et al. (2004) ALpha1-adrenoceptor antagonist properties of CGP 12177A and other beta-adrenoceptor ligands: evidence against beta(3)- or atypical beta-adrenoceptors in rat aorta. Br J Pharmacol. 142:781
PMID: 15205310
Geerts et al. (1999) Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery. Br J Pharmacol. 127:1327
PMID: 10455282

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