Recombinant Human Wnt-3a Protein
R&D Systems, Inc. a Bio-Techne Brand
Key Product Details
Source: | CHO |
Accession #: | NP_149122 |
Applications: | Bioactivity |
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Citations for Recombinant Human Wnt-3a Protein (319)
Citations are publications that use Bio-Techne products. Selected citations for Recombinant Human Wnt-3a Protein include:
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Species: Human
Sample Types: Whole Cells
Applications: BioassayK Stoletov et al. (2023-01-01), Intravital imaging of Wnt/beta-catenin and ATF2-dependent signalling pathways during tumour cell invasion and metastasis Journal of Cell Science, 0(0).
PMID: 36621522 -
Species: Frog
Sample Types: Embryo
Applications: BioassayC Seidl et al. (2023), Mucociliary Wnt signaling promotes cilia biogenesis and beating Nature Communications, 14(1):1259.
PMID: 36878953 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayB Geleta et al. (2022-01-01), Targeting Wnt/Tenascin C-Mediated Cross Talk between Pancreatic Cancer Cells and Stellate Cells via activation of the Metastasis Suppressor NDRG1 The Journal of Biological Chemistry, 0(0):101608.
PMID: 35065073 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayY Han et al. (2022-01-01), Coordinate control of basal epithelial cell fate and stem cell maintenance by core EMT transcription factor Zeb1 Cell Reports, 38(2):110240.
PMID: 35021086 -
Species: Human
Sample Types: Organoids
Applications: BioassayMM Capeling et al. (2022-01-01), Suspension culture promotes serosal mesothelial development in human intestinal organoids Cell Reports, 38(7):110379.
PMID: 35172130 -
Species: Human
Sample Types: Transduced Whole Cells
Applications: BioassayJ Jeong et al. (2022-01-01), Elimination of Reprogramming Transgenes Facilitates the Differentiation of Induced Pluripotent Stem Cells into Hepatocyte-like Cells and Hepatic Organoids Biology, 11(4).
PMID: 35453693 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayZ Li et al. (2022-01-01), Hotspot ESR1 mutations are multimodal and contextual modulators of breast cancer metastasis Cancer Research, 0(0).
PMID: 35078818 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayCJ Brereton et al. (2022-01-01), Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis Elife, 11(0).
PMID: 35188460 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayCW Wasson et al. (2022-01-01), Induction of Pro-Fibrotic CLIC4 in Dermal Fibroblasts by TGF-beta/Wnt3a Is Mediated by GLI2 Upregulation Cells, 11(3).
PMID: 35159339 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJ Fu et al. (2022-01-01), Generation of a human iPSC line CIBi010-A with a reporter for ASGR1 using CRISPR/Cas9 Stem Cell Research, 62(0):102800.
PMID: 35561459 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureM Naumann et al. (2022-01-01), Combined Systemic Drug Treatment with Proton Therapy: Investigations on Patient-Derived Organoids Cancers, 14(15).
PMID: 35954444 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayS Condello et al. (2022-01-01), Tissue transglutaminase activates integrin-linked kinase and beta-catenin in ovarian cancer The Journal of Biological Chemistry, 0(0):102242.
PMID: 35810788 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayC Shen et al. (2022-01-01), The Casein kinase 1alpha agonist pyrvinium attenuates Wnt-mediated CK1alpha degradation via interaction with the E3 ubiquitin ligase component Cereblon The Journal of Biological Chemistry, 0(0):102227.
PMID: 35780831 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayY Tian et al. (2022-01-01), WRN promotes bone development and growth by unwinding SHOX-G-quadruplexes via its helicase activity in Werner Syndrome Nature Communications, 13(1):5456.
PMID: 36114168 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayR Moser et al. (2022-01-01), Pharmacological targeting of TFIIH suppresses KRAS mutant pancreatic ductal adenocarcinoma and synergizes with TRAIL Cancer Research, 0(0).
PMID: 35819261 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayS Gupta et al. (2022-01-01), In�vitro atlas of dorsal spinal interneurons reveals Wnt signaling as a critical regulator of progenitor expansion Oncogene, 40(3):111119.
PMID: 35858555 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayY Shi et al. (2022-01-01), Generation of Hepatocytes and Nonparenchymal Cell Codifferentiation System from Human-Induced Pluripotent Stem Cells Stem Cells International, 2022(0):3222427.
PMID: 36467281 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayV Lungova et al. (2022-01-01), Exposure to e-cigarette vapor extract induces vocal fold epithelial injury and triggers intense mucosal remodeling Oncogene, 0(0).
PMID: 35770504 -
Species: Human
Sample Types: Whole Cell
Applications: Cell CultureMG Lee et al. (2022-01-01), Nuclear S6K1 Enhances Oncogenic Wnt Signaling by Inducing Wnt/beta-Catenin Transcriptional Complex Formation International Journal of Molecular Sciences, 23(24).
PMID: 36555784 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayWC Hwang et al. (2022-01-01), Inhibition of phospholipase D1 induces immunogenic cell death and potentiates cancer immunotherapy in colorectal cancer Experimental Molecular Medicine, 2022;0(0).
PMID: 36131027 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureD Song et al. (2022-01-01), Insulin-like growth factor 2 mRNA-binding protein 3 promotes kidney injury by regulating beta-catenin signaling JCI Insight, 0(0).
PMID: 36520532 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayA Fregnani et al. (2022-01-01), CK1alpha/RUNX2 Axis in the Bone Marrow Microenvironment: A Novel Therapeutic Target in Multiple Myeloma Cancers, 14(17).
PMID: 36077711 -
Species: Human
Sample Types: Whole Cells
Applications: StimulationH Ngai et al. (2022-01-01), LEF1 drives a central memory program and supports antitumor activity of natural killer T cells Cancer Immunology Research, 0(0).
PMID: 36484736 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayK Nagano et al. (2022-01-01), R-spondin 3 deletion induces Erk phosphorylation to enhance Wnt signaling and promote bone formation in the appendicular skeleton Elife, 11(0).
PMID: 36321691 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayL Jiang et al. (2022-01-01), Ivermectin inhibits tumor metastasis by regulating the Wnt/beta-catenin/integrin beta1/FAK signaling pathway American journal of cancer research, 12(10):4502-4519.
PMID: 36381328 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureP Paclíková et al. (2021-01-01), Roles of individual human Dishevelled paralogs in the Wnt signalling pathways Cellular Signalling, 85(0):110058.
PMID: 34082011 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayD Baek et al. (2021-01-01), Ubiquitin-specific protease 53 promotes osteogenic differentiation of human bone marrow-derived mesenchymal stem cells Cell Death Disease, 2021;12(3):238.
PMID: 33664230 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayS Akbari et al. (2021-01-01), LGR5/R-Spo1/Wnt3a axis promotes stemness and aggressive phenotype in hepatoblast-like hepatocellular carcinoma cell lines Cellular Signalling, 0(0):109972.
PMID: 33684507 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJ Quandt et al. (2021-01-01), Wnt-&beta-catenin activation epigenetically reprograms Treg cells in inflammatory bowel disease and dysplastic progression Nature Immunology, 0(0).
PMID: 33664518 -
Species: Human
Sample Types: Plasmid
Applications: BioassayJ Du et al. (2021-01-01), ATF4 promotes lung cancer cell proliferation and invasion partially through regulating Wnt/&beta-catenin signaling International Journal of Medical Sciences, 18(6):1442-1448.
PMID: 33628101 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureI Fischer et al. (2021-01-01), Generation of human induced pluripotent stem cell lines from 2 patients with MIRAGE syndrome Stem Cell Research, 54(0):102417.
PMID: 34119956 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayPL Ramanujam et al. (2021-01-01), Global chromatin organizer SATB1 acts as a context-dependent regulator of the Wnt/Wg target genes Scientific Reports, 11(1):3385.
PMID: 33564000 -
Species: Human
Sample Types: Cell Lysates
Applications: Western BlotYH Cui et al. (2021-01-01), Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis Nature Communications, 12(1):2183.
PMID: 33846348 -
Species: Human
Sample Types: Organoid
Applications: BioassayN Raj et al. (2021-01-01), Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis Cell Reports, 35(2):108991.
PMID: 33852833 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJN Kuehner et al. (2021-01-01), 5-hydroxymethylcytosine is dynamically regulated during forebrain organoid development and aberrantly altered in Alzheimer's disease Cell Reports, 35(4):109042.
PMID: 33910000 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayQD Deng et al. (2021-01-01), Triptolide suppresses the growth and metastasis of non-small cell lung cancer by inhibiting &beta-catenin-mediated epithelial-mesenchymal transition Acta pharmacologica Sinica, 0(0).
PMID: 33893396 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayA Sinha et al. (2021-01-01), Repression of Wnt/&beta-catenin signaling by SOX9 and Mastermind-like transcriptional coactivator 2 Science Advances, 7(8).
PMID: 33597243 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayO Kwon et al. (2021-01-01), The development of a functional human small intestinal epithelium model for drug absorption Science Advances, 7(23).
PMID: 34078609 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayTW Fowler et al. (2021-01-01), Development of selective bispecific Wnt mimetics for bone loss and repair Nature Communications, 12(1):3247.
PMID: 34059688 -
Species: Equine
Sample Types: Organoid
Applications: BioassayS Hellman (2021-01-01), Generation of equine enteroids and enteroid-derived 2D monolayers that are responsive to microbial mimics Veterinary research, 52(1):108.
PMID: 34391473 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayAV Parent et al. (2021-01-01), Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection Cell Reports, 36(7):109538.
PMID: 34407395 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayX Yang et al. (2021-01-01), WNT/&beta-catenin-suppressed FTO expression increases m6A of c-Myc mRNA to promote tumor cell glycolysis and tumorigenesis Cell Death Disease, 2021;12(5):462.
PMID: 33966037 -
W Liu et al. (2021-01-01), KAT6A, a novel regulator of &beta-catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1 Theranostics, 11(13):6278-6292.
PMID: 33995658 -
Species: Human
Sample Types: Organoid
Applications: BioassayY Kang et al. (2021-01-01), A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies Nature Neuroscience, 0(0).
PMID: 34413513 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayT Radaszkiew et al. (2021-01-01), RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy Elife, 10(0).
PMID: 34702444 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayKM Mackinlay et al. (2021-01-01), An in vitro stem cell model of human epiblast and yolk sac interaction Elife, 10(0).
PMID: 34403333 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayL Johnson Ch et al. (2021-01-01), Transcriptome-Wide Analysis Reveals a Role for Extracellular Matrix and Integrin Receptor Genes in Otic Neurosensory Differentiation from Human iPSCs International Journal of Molecular Sciences, 22(19).
PMID: 34639189 -
Species: Human
Sample Types: Cell Lysates
Applications: BioassayM Yang et al. (2021-01-01), KCTD11 inhibits progression of lung cancer by binding to beta-catenin to regulate the activity of the Wnt and Hippo pathways Journal of Cellular and Molecular Medicine, 0(0).
PMID: 34453479 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayC Shen et al. (2021-01-01), The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling Nature Communications, 12(1):5263.
PMID: 34489457 -
Species: Human
Sample Types: Organoids
Applications: BioassaySA Saenz et al. (2021-01-01), Small molecule allosteric inhibitors of RORgammat block Th17-dependent inflammation and associated gene expression in vivo PLoS ONE, 16(11):e0248034.
PMID: 34752458 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayAK Eicher et al. (2021-01-01), Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells Cell Stem Cell, 0(0).
PMID: 34856121 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayS Hu et al. (2021-01-01), Glycoprotein PTGDS promotes tumorigenesis of diffuse large B-cell lymphoma by MYH9-mediated regulation of Wnt-beta-catenin-STAT3 signaling Cell Death and Differentiation, 0(0).
PMID: 34743203 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayM Kowalski-J et al. (2021-01-01), Frizzled BRET sensors based on bioorthogonal labeling of unnatural amino acids reveal WNT-induced dynamics of the cysteine-rich domain Science Advances, 7(46):eabj7917.
PMID: 34757789 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayV Chesnokova et al. (2021-01-01), Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage Cell Reports, 37(11):110068.
PMID: 34910915 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayQ Yan et al. (2021-01-01), PGC7 promotes tumor oncogenic dedifferentiation through remodeling DNA methylation pattern for key developmental transcription factors Cell Death and Differentiation, 0(0).
PMID: 33500560 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayC Völkner et al. (2021-01-01), Patient-Specific iPSC-Derived Neural Differentiated and Hepatocyte-like Cells, Carrying the Compound Heterozygous Mutation p.V1023Sfs*15/p.G992R, Present the "Variant" Biochemical Phenotype of Niemann-Pick Type C1 Disease International Journal of Molecular Sciences, 22(22).
PMID: 34830064 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayR Santos et al. (2021-01-01), Deficient LEF1 expression is associated with lithium resistance and hyperexcitability in neurons derived from bipolar disorder patients Molecular Psychiatry, 0(0).
PMID: 33398088 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayCL Wu et al. (2021-01-01), Single cell transcriptomic analysis of human pluripotent stem cell chondrogenesis Nature Communications, 12(1):362.
PMID: 33441552 -
Species: Human
Sample Types: Organoid
Applications: BioassayM Tajan et al. (2021-01-01), Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy Nature Communications, 12(1):366.
PMID: 33446657 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayC Gil-Recio et al. (2021-01-01), Chemically Defined Conditions Mediate an Efficient Induction of Dental Pulp Pluripotent-Like Stem Cells into Hepatocyte-Like Cells Stem Cells International, 2021(0):5212852.
PMID: 34795766 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayM Romano et al. (2021-01-01), Pluripotent Stem Cell-Derived Hepatocytes Inhibit T Cell Proliferation In Vitro through Tryptophan Starvation Cells, 11(1).
PMID: 35011586 -
Species: Human
Sample Types: Organoid, Organoids
Applications: BioassayA Sagara et al. (2021-01-01), Repositioning of duloxetine to target pancreatic stellate cells Oncology Letters, 22(4):744.
PMID: 34466156 -
Species: Human
Sample Types: Whole Cell
Applications: BioassayL Chen et al. (2021-01-01), USP28 facilitates pancreatic cancer progression through activation of Wnt/beta-catenin pathway via stabilising FOXM1 Cell Death Disease, 2021;12(10):887.
PMID: 34584067 -
Species: Human
Sample Types: Organoid
Applications: BioassayK Husain et al. (2021-01-01), Farnesyl dimethyl chromanol targets colon cancer stem cells and prevents colorectal cancer metastasis Scientific Reports, 11(1):2185.
PMID: 33500430 -
Species: Human
Sample Types: Organoid
Applications: BioassayT Ebisudani et al. (2021-01-01), Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening Cell Reports, 0(0):109218.
PMID: 34038715 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureP Kozielewic et al. (2020-01-01), Structural insight into small molecule action on Frizzleds Nat Commun, 11(1):414.
PMID: 31964872 -
Species: Human
Applications: Cell CultureFH Brasil da et al. (2020-01-01), SULF1 suppresses Wnt3A-driven growth of bone metastatic prostate cancer in perlecan-modified 3D cancer-stroma-macrophage triculture models PLoS ONE, 15(5):e0230354.
PMID: 32413029 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureA Fleischer et al. (2020-01-01), iPSC-Derived Intestinal Organoids from Cystic Fibrosis Patients Acquire CFTR Activity upon TALEN-Mediated Repair of the p.F508del Mutation Mol Ther Methods Clin Dev, 17(0):858-870.
PMID: 32373648 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayM Bowers et al. (2020-01-01), FASN-Dependent Lipid Metabolism Links Neurogenic Stem/Progenitor Cell Activity to Learning and Memory Deficits Cell Stem Cell, 0(0).
PMID: 32386572 -
Species: Human
Sample Types: Whole Cell
Applications: BioassayE Flores-Her et al. (2020-01-01), Canonical and non-canonical Wnt signaling are simultaneously activated by Wnts in colon cancer cells Cell. Signal., 72(0):109636.
PMID: 32283254 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayS Yoshida et al. (2020-01-01), Generation of intestinal organoids derived from human pluripotent stem cells for drug testing Sci Rep, 10(1):5989.
PMID: 32249832 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayF He et al. (2020-01-01), LSD1 inhibition yields functional insulin-producing cells from human embryonic stem cells Stem Cell Res Ther, 11(1):163.
PMID: 32345350 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureQ Li et al. (2020-01-01), Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription Cell Stem Cell, 26(5):675-692.e8.
PMID: 32259481 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayX Shi et al. (2020-01-01), Identification and validation of the phosphorylation sites on Aristaless-related homeobox protein Biosci. Rep., 40(7).
PMID: 32608477 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureY Wu et al. (2020-01-01), Expression of MALAT1 Promotes Trastuzumab Resistance in HER2 Overexpressing Breast Cancers Cancers (Basel), 12(7).
PMID: 32708561 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureW Kawarazaki et al. (2020-01-01), Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency J. Clin. Invest., 0(0).
PMID: 32597829 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureR Castro-Viñ et al. (2020-01-01), Generation and characterization of human induced pluripotent stem cells (iPSCs) from hand osteoarthritis patient-derived fibroblasts Sci Rep, 10(1):4272.
PMID: 32144293 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayR Griffiths et al. (2020-01-01), The Transcription Factor-microRNA Regulatory Network during hESC-chondrogenesis Sci Rep, 10(1):4744.
PMID: 32179818 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayS Komura et al. (2020-01-01), Induced pluripotent stem cell-derived tenocyte-like cells promote the regeneration of injured tendons in mice Sci Rep, 10(1):3992.
PMID: 32132649 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayWY Liao et al. (2020-01-01), Dishevelled 1-Regulated Superpotent Cancer Stem Cells Mediate Wnt Heterogeneity and Tumor Progression in Hepatocellular Carcinoma Stem Cell Reports, 14(3):462-477.
PMID: 32160521 -
Species: Mouse
Sample Types: Whole Cells
Applications: Cell CultureV Uribe-Etxe et al. (2020-01-01), Wnt-3a Induces Epigenetic Remodeling in Human Dental Pulp Stem Cells Cells, 9(3).
PMID: 32156036 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureM Liu et al. (2020-01-01), A hepatocyte differentiation model reveals two subtypes of liver cancer with different oncofetal properties and therapeutic targets Proc. Natl. Acad. Sci. U.S.A., 0(0).
PMID: 32123069 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureA El-Sehemy et al. (2020-01-01), Norrin mediates tumor-promoting and -suppressive effects in glioblastoma via Notch and WNT J. Clin. Invest., 0(0).
PMID: 32182224 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureL Omer et al. (2020-01-01), Familial hypercholesterolemia class II low density lipoprotein-receptor response to statin treatment Dis Model Mech, 0(0).
PMID: 32005714 -
Species: Bovine
Sample Types: Whole Cells
Applications: BioassayM Díaz-Corán et al. (2020-01-01), Norrin restores blood-retinal barrier properties after vascular endothelial growth factor-induced permeability J. Biol. Chem., 0(0).
PMID: 32086377 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureJC Lim et al. (2020-01-01), Activation of &beta-catenin by TGF-&beta1 promotes ligament-fibroblastic differentiation and inhibits cementoblastic differentiation of human periodontal ligament cells Stem Cells, 0(0).
PMID: 32930424 -
Species: Human
Sample Types: Organoid
Applications: Cell CultureK Dunbar et al. (2020-01-01), Aspirin Rescues Wnt-Driven Stem-like Phenotype in Human Intestinal Organoids and Increases the Wnt Antagonist Dickkopf-1 Cell Mol Gastroenterol Hepatol, 0(0).
PMID: 32971322 -
Species: Chlorocebus aethiops (green monkey)
Sample Types: Whole Cells
Applications: Cell CultureJ Wang et al. (2020-01-01), Wnt/&beta-catenin signaling pathway inhibits porcine reproductive and respiratory syndrome virus replication by enhancing the nuclear factor-&kappaB-dependent innate immune response Veterinary Microbiology, 251(0):108904.
PMID: 33181435 -
Species: Porcine
Sample Types: Whole Cells
Applications: BioassayM Zhu et al. (2020-01-01), Fallopian Tube Basal Stem Cells Reproducing the Epithelial Sheets In Vitro-Stem Cell of Fallopian Epithelium Biomolecules, 10(9).
PMID: 32899226 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureS Wu et al. (2020-01-01), Generation of a human iPSC line CIBi008-A from amniotic fluid-derived cells of a fetus with &beta-thalassemia carrying variants of -28A�>�G and IVS-II-654C�>�T in HBB Stem Cell Res, 49(0):102074.
PMID: 33157391 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayMP Srikanth et al. (2020-01-01), Elevated Dkk1 Mediates Downregulation of the Canonical Wnt Pathway and Lysosomal Loss in an iPSC Model of Neuronopathic Gaucher Disease Biomolecules, 10(12).
PMID: 33287247 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayL Wei et al. (2020-01-01), PWP1 Promotes the Malignant Phenotypes of Lung Cancer Cells by Interacting with DVL2 and Merlin Onco Targets Ther, 13(0):10025-10037.
PMID: 33116587 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureS Nagel et al. (2020-01-01), Aberrant expression of NKL homeobox genes HMX2 and HMX3 interferes with cell differentiation in acute myeloid leukemia PLoS ONE, 15(10):e0240120.
PMID: 33048949 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayW Chong et al. (2020-01-01), Aquaporin 1 promotes sensitivity of anthracycline chemotherapy in breast cancer by inhibiting &beta-catenin degradation to enhance TopoII&alpha activity Cell Death Differ., 0(0).
PMID: 32814878 -
Species: Mouse
Sample Types: Whole Cells
Applications: Cell CultureAJ Bilotta et al. (2020-01-01), Propionate Enhances Cell Speed and Persistence to Promote Intestinal Epithelial Turnover and Repair Cell Mol Gastroenterol Hepatol, 0(0).
PMID: 33238220 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayS Pagliari et al. (2020-01-01), YAP-TEAD1 control of cytoskeleton dynamics and intracellular tension guides human pluripotent stem cell mesoderm specification Cell Death Differ, 0(0).
PMID: 33116297 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayF Michielin et al. (2020-01-01), The Microfluidic Environment Reveals a Hidden Role of Self-Organizing Extracellular Matrix in Hepatic Commitment and Organoid Formation of hiPSCs Cell Rep, 33(9):108453.
PMID: 33264615 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayPN Kluz et al. (2020-01-01), Cancer cell-intrinsic function of CD177 in attenuating beta-catenin signaling Oncogene, 39(14):2877-2889.
PMID: 32042113 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayA Moiseenko et al. (2020-01-01), Identification of a Repair-Supportive Mesenchymal Cell Population during Airway Epithelial Regeneration Cell Reports, 33(12):108549.
PMID: 33357434 -
Species: Human
Sample Types: Whole Cell
Applications: Cell CultureJP Gleeson et al. (2020-01-01), Development of Physiologically Responsive Human iPSC-Derived Intestinal Epithelium to Study Barrier Dysfunction in IBD Int J Mol Sci, 21(4).
PMID: 32093254 -
Species: Human
Sample Types: Organoid, Whole Cells
Applications: BioassayL Zhang et al. (2020-01-01), Generation of Functional Brown Adipocytes from Human Pluripotent Stem Cells via Progression through a Paraxial Mesoderm State Cell Stem Cell, 0(0).
PMID: 32783886 -
Species: Human
Sample Types: Cell Lysates, Organoid
Applications: Bioassay, Cell CultureZ Dantes et al. (2020-01-01), Implementing cell-free DNA of pancreatic cancer patient-derived organoids for personalized oncology JCI Insight, 5(15).
PMID: 32614802 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassay, Cell CultureY Gong et al. (2020-01-01), R-Spondin 2 Induces Odontogenic Differentiation of Dental Pulp Stem/Progenitor Cells via Regulation of Wnt/beta-Catenin Signaling Front Physiol, 11(0):918.
PMID: 32848860 -
Species: Human
Sample Types: Organoid
Applications: BioassayT Sawada et al. (2020-01-01), Developmental excitation-inhibition imbalance underlying psychoses revealed by single-cell analyses of discordant twins-derived cerebral organoids Mol. Psychiatry, 0(0).
PMID: 32764691 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayS Xu et al. (2020-01-01), Understanding the regulatory mechanisms of endometrial cells on activities of endometrial mesenchymal stem-like cells during menstruation Stem Cell Res Ther, 11(1):239.
PMID: 32552749 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayK Wei et al. (2020-01-01), Notch signalling drives synovial fibroblast identity and arthritis pathology Nature, 582(7811):259-264.
PMID: 32499639 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayS Grosswendt et al. (2020-01-01), Epigenetic regulator function through mouse gastrulation Nature, 584(7819):102-108.
PMID: 32728215 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayO McGinn et al. (2020-01-01), Cytokeratin 5 alters beta-catenin dynamics in breast cancer cells Oncogene, 39(12):2478-2492.
PMID: 31988452 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayNY Loh et al. (2020-01-01), RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro Nat Commun, 11(1):2797.
PMID: 32493999 -
Species: Human
Sample Types: Organoids
Applications: BioassayT Kijima et al. (2019-01-01), Three-Dimensional Organoids Reveal Therapy Resistance of Esophageal and Oropharyngeal Squamous Cell Carcinoma Cells Cell Mol Gastroenterol Hepatol, 7(1):73-91.
PMID: 30510992 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayX Yu et al. (2019-01-01), ZNF326 promotes malignant phenotype of glioma by up-regulating HDAC7 expression and activating Wnt pathway J. Exp. Clin. Cancer Res., 38(1):40.
PMID: 30691485 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayV Chesnokova et al. (2019-01-01), Excess growth hormone suppresses DNA damage repair in epithelial cells JCI Insight, 4(3).
PMID: 30728323 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayH Noguchi et al. (2019-01-01), Induction of Expandable Tissue-Specific Progenitor Cells from Human Pancreatic Tissue through Transient Expression of Defined Factors Mol Ther Methods Clin Dev, 13(0):243-252.
PMID: 30828587 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayK Götzel et al. (2019-01-01), In-depth characterization of the Wnt-signaling/?-catenin pathway in an in vitro model of Barrett's sequence BMC Gastroenterol, 19(1):38.
PMID: 30841855 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayO Lyros et al. (2019-01-01), Dickkopf-1 (DKK1) promotes tumor growth via Akt-phosphorylation and independently of Wnt-axis in Barrett's associated esophageal adenocarcinoma Am J Cancer Res, 9(2):330-346.
PMID: 30906632 -
Species: Human
Sample Types: Whole Cells
X Wang et al. (2019-01-01), Point mutations in the PDX1 transactivation domain impair human ?-cell development and function Mol Metab, 0(0).
PMID: 30930126 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayP Shooshtari et al. (2019-01-01), Gfi1b regulates the level of Wnt/?-catenin signaling in hematopoietic stem cells and megakaryocytes Nat Commun, 10(1):1270.
PMID: 30894540 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayT Colunga et al. (2019-01-01), Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair Cell Rep, 26(10):2566-2579.e10.
PMID: 30840882 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayL Liu et al. (2019-01-01), An integrated chromatin accessibility and transcriptome landscape of human pre-implantation embryos Nat Commun, 10(1):364.
PMID: 30664750 -
Species: Fish - Oryzias latipes (Medaka/Rice Fish)
Sample Types: In Vivo
Applications: In VivoK Abe et al. (2019-01-01), Horizontal Boundary Cells, a Special Group of Somitic Cells, Play Crucial Roles in the Formation of Dorsoventral Compartments in Teleost Somite Cell Rep, 27(3):928-939.e4.
PMID: 30995487 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayK Kaiser et al. (2019-01-01), WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis Nat Commun, 10(1):1498.
PMID: 30940800 -
Species: Human
Sample Types: Organoids
Applications: BioassayZ Yan et al. (2019-01-01), Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer-stromal interaction and metastasis J. Exp. Clin. Cancer Res., 38(1):221.
PMID: 31133044 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayT Wang et al. (2019-01-01), Enhanced chondrogenesis from human embryonic stem cells Stem Cell Res, 39(0):101497.
PMID: 31326745 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureCP Nielsen et al. (2019-01-01), USP9X Deubiquitylates DVL2 to Regulate WNT Pathway Specification Cell Rep, 28(4):1074-1089.e5.
PMID: 31340145 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureY Wen et al. (2019-01-01), COL4A2 in the tissue-specific extracellular matrix plays important role on osteogenic differentiation of periodontal ligament stem cells Theranostics, 9(15):4265-4286.
PMID: 31285761 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayCL Hammond et al. (2019-01-01), Proton pump inhibitors attenuate myofibroblast formation associated with thyroid eye disease through the aryl hydrocarbon receptor PLoS ONE, 14(9):e0222779.
PMID: 31536596 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayAG Hawkins et al. (2019-01-01), Microenvironmental Factors Drive Tenascin C and Src Cooperation to Promote Invadopodia Formation in Ewing Sarcoma Neoplasia, 21(10):1063-1072.
PMID: 31521948 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayF Tonon et al. (2019-01-01), In vitro metabolic zonation through oxygen gradient on a chip Sci Rep, 9(1):13557.
PMID: 31537830 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureS Akbari et al. (2019-01-01), Robust, Long-Term Culture of Endoderm-Derived Hepatic Organoids for Disease Modeling Stem Cell Reports, 13(4):627-641.
PMID: 31522975 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayC Praça et al. (2019-01-01), Derivation of Brain Capillary-like Endothelial Cells from Human Pluripotent Stem Cell-Derived Endothelial Progenitor Cells Stem Cell Reports, 13(4):599-611.
PMID: 31495714 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayV Lungova et al. (2019-01-01), Human induced pluripotent stem cell-derived vocal fold mucosa mimics development and responses to smoke exposure Nat Commun, 10(1):4161.
PMID: 31551422 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayKB Jung et al. (2019-01-01), Blockade of STAT3 Causes Severe In Vitro and In Vivo Maturation Defects in Intestinal Organoids Derived from Human Embryonic Stem Cells J Clin Med, 8(7).
PMID: 31277507 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayY Zheng et al. (2019-01-01), Controlled modelling of human epiblast and amnion development using stem cells Nature, 573(7774):421-425.
PMID: 31511693 -
Species: Mouse
Sample Types: Whole Tissue
Applications: BioassayRR Stine et al. (2019-01-01), PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism Cell Stem Cell, 0(0).
PMID: 31564549 -
Species: Porcine
Sample Types: Whole Tissue
Applications: Tissue CultureAP Singh et al. (2019-01-01), Enteroendocrine progenitor cell enriched miR-7 regulates intestinal epithelial proliferation in an Xiap-dependent manner Cell Mol Gastroenterol Hepatol, 0(0).
PMID: 31756561 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayKH Grinnemo et al. (2019-01-01), Immunomodulatory effects of interferon-gamma on human fetal cardiac mesenchymal stromal cells Stem Cell Res Ther, 10(1):371.
PMID: 31801632 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureR Eyre et al. (2019-01-01), Microenvironmental IL1beta promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling Nat Commun, 10(1):5016.
PMID: 31676788 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureZ Ye et al. (2019-01-01), Wnt Glycation Inhibits Canonical Signaling Cells, 8(11).
PMID: 31731544 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayG Ferrer-May et al. (2019-01-01), Vitamin D and Wnt3A have additive and partially overlapping modulatory effects on gene expression and phenotype in human colon fibroblasts Sci Rep, 9(1):8085.
PMID: 31147591 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayM Huang et al. (2019-01-01), Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis Cell Stem Cell, 0(0).
PMID: 31204176 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayK Aripaka et al. (2019-01-01), TRAF6 function as a novel co-regulator of Wnt3a target genes in prostate cancer EBioMedicine, 0(0).
PMID: 31262711 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayH Zhao et al. (2019-01-01), E2A attenuates tumor-initiating capacity of colorectal cancer cells via the Wnt/beta-catenin pathway J. Exp. Clin. Cancer Res., 38(1):276.
PMID: 31234887 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayA Sarkar et al. (2018-01-01), Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In�Vitro Cell Stem Cell, 22(5):684-697.e9.
PMID: 29727680 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayQ Li et al. (2018-01-01), A simple and scalable hydrogel-based system for culturing protein-producing cells PLoS ONE, 13(1):e0190364.
PMID: 29293594 -
Species: Porcine
Sample Types: Whole Cells
Applications: BioassayXG Li et al. (2018-01-01), LGR5 and BMI1 Increase Pig Intestinal Epithelial Cell Proliferation by Stimulating WNT/?-Catenin Signaling Int J Mol Sci, 19(4).
PMID: 29601474 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayHK Lee et al. (2018-01-01), Ubiquitylation and degradation of adenomatous polyposis coli by MKRN1 enhances Wnt/?-catenin signaling Oncogene, 0(0).
PMID: 29713058 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayM Szemes et al. (2018-01-01), Wnt Signalling Drives Context-Dependent Differentiation or Proliferation in Neuroblastoma Neoplasia, 20(4):335-350.
PMID: 29505958 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayHJ Lee et al. (2018-01-01), Cholesterol Esterification Inhibition Suppresses Prostate Cancer Metastasis by Impairing the Wnt/?-catenin Pathway Mol. Cancer Res., 0(0).
PMID: 29545473 -
Species: Human
Sample Types: Organoids
Applications: BioassayD Garnier et al. (2018-01-01), Expansion of human primary hepatocytes in vitro through their amplification as liver progenitors in a 3D organoid system Sci Rep, 8(1):8222.
PMID: 29844473 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayBN Nakamura et al. (2018-01-01), A20 regulates canonical wnt-signaling through an interaction with RIPK4 PLoS ONE, 13(5):e0195893.
PMID: 29718933 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayM Amin et al. (2018-01-01), Cardiotrophic Growth Factor-Driven Induction of Human Muse Cells Into Cardiomyocyte-Like Phenotype Cell Transplant, 27(2):285-298.
PMID: 29637816 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayM Russo et al. (2018-01-01), Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies Nat Commun, 9(1):2287.
PMID: 29895949 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJ Li et al. (2018-01-01), Functional 3D Human Liver Bud Assembled from MSC-Derived Multiple Liver Cell Lineages Cell Transplant, 0(0):9636897187803.
PMID: 29895168 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayS Condello et al. (2018-01-01), Tissue transglutaminase regulates interactions between ovarian cancer stem cells and the tumor niche Cancer Res., 0(0).
PMID: 29510995 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayX Wang et al. (2018-01-01), Genome-wide analysis of PDX1 target genes in human pancreatic progenitors Mol Metab, 0(0).
PMID: 29396371 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayS Kokabu et al. (2018-01-01), BMP3 expression by osteoblast lineage cells is regulated by canonical Wnt signaling FEBS Open Bio, 8(2):168-176.
PMID: 29435407 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayY Sui et al. (2018-01-01), IKK? is a ?-catenin kinase that regulates mesenchymal stem cell differentiation JCI Insight, 3(2).
PMID: 29367460 -
Species: Rat
Sample Types: Whole Cells
Applications: BioassayY Zhao et al. (2018-01-01), An essential role for Wnt/?-catenin signaling in mediating hypertensive heart disease Sci Rep, 8(1):8996.
PMID: 29895976 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayH He et al. (2018-01-01), The Wnt-?-catenin signaling regulated MRTF-A transcription to activate migration-related genes in human breast cancer cells Oncotarget, 9(20):15239-15251.
PMID: 29632640 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayE Magro-Lope et al. (2018-01-01), Effects of lung and airway epithelial maturation cocktail on the structure of lung bud organoids Stem Cell Res Ther, 9(1):186.
PMID: 29996941 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayS Yamada et al. (2018-01-01), Tributyltin Inhibits Neural Induction of Human Induced Pluripotent Stem Cells Sci Rep, 8(1):12155.
PMID: 30108368 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayH Ida et al. (2018-01-01), Establishment of a rapid and footprint-free protocol for differentiation of human embryonic stem cells into pancreatic endocrine cells with synthetic mRNAs encoding transcription factors Stem Cell Res Ther, 9(1):277.
PMID: 30359326 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJ Li et al. (2018-01-01), A transient DMSO treatment increases the differentiation potential of human pluripotent stem cells through the Rb family PLoS ONE, 13(12):e0208110.
PMID: 30540809 -
Species: Human
Sample Types: Organoids
Applications: BioassayC Bonamy et al. (2018-01-01), Expression of the human antimicrobial peptide ?-defensin-1 is repressed by the EGFR-ERK-MYC axis in colonic epithelial cells Sci Rep, 8(1):18043.
PMID: 30575780 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayBA Brown et al. (2018-01-01), Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells Aging Cell, 0(0):e12844.
PMID: 30548452 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayQ Peng et al. (2018-01-01), EPH receptor A2 governs a feedback loop that activates Wnt/?-catenin signaling in gastric cancer Cell Death Dis, 9(12):1146.
PMID: 30451837 -
Species: Human
Sample Types: Cell Lysates
Applications: Immunoassay DevelopmentK Jeon et al. (2018-01-01), GLIS3 Transcriptionally Activates WNT Genes to Promote Differentiation of Human Embryonic Stem Cells into Posterior Neural Progenitors Stem Cells, 0(0).
PMID: 30376208 -
Species: Mouse
Sample Types: Whole Tissue
Applications: BioassayR Diacou et al. (2018-01-01), Six3 and Six6 Are Jointly Required for the Maintenance of Multipotent Retinal Progenitors through Both Positive and Negative Regulation Cell Rep, 25(9):2510-2523.e4.
PMID: 30485816 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayKE Worley et al. (2018-01-01), Lineage-Specific Chiral Biases of Human Embryonic Stem Cells during Differentiation Stem Cells Int, 2018(0):1848605.
PMID: 30627170 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayB Cha et al. (2018-01-01), Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/?-Catenin Signaling Cell Rep, 25(3):571-584.e5.
PMID: 30332639 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayA Ogorodniko et al. (2018-01-01), Transcriptome 3'end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma Nat Commun, 9(1):5331.
PMID: 30552333 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayMichael J Workman et al. (2018-01-01), Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips. Cellular and Molecular Gastroenterology and Hepatology, 0(0):2352-345X.
PMID: 29930984 -
Species: Human
Sample Types: Organoids
Applications: BioassayE Sechet et al. (2018-01-01), Natural molecules induce and synergize to boost expression of the human antimicrobial peptide ?-defensin-3 Proc. Natl. Acad. Sci. U.S.A., 0(0).
PMID: 30275324 -
Species: Human
Sample Types: Whole Cells
AG Hawkins et al. (2018-01-01), The Ewing sarcoma secretome and its response to activation of Wnt/beta-catenin signaling Mol. Cell Proteomics, 0(0).
PMID: 29386236 -
Species: Human
Sample Types: Whole Cells
Applications: StimulationS Lamprecht et al. (2018-01-01), PBX3 is part of an EMT regulatory network and indicates poor outcome in colorectal cancer Clin. Cancer Res., 0(0).
PMID: 29391352 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureJ Gillespie et al. (2018-01-01), TGF? activation primes canonical Wnt signaling through the downregulation of AXIN2 Arthritis rheumatology (Hoboken, N.J.), 2018;0(0).
PMID: 29409120 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayLA Ahrens et al. (2017-01-01), Gelatin device for the delivery of growth factors involved in endochondral ossification PLoS ONE, 12(4):e0175095.
PMID: 28380024 -
Species: Mouse
Sample Types: Whole Embryo
Applications: BioassayK Minegishi et al. (2017-01-01), A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking Dev. Cell, 40(5):439-452.e4.
PMID: 28292423 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayZ Wen et al. (2017-01-01), Up-regulated NRIP2 in colorectal cancer initiating cells modulates the Wnt pathway by targeting ROR? Mol. Cancer, 16(1):20.
PMID: 28137278 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayA Asai et al. (2017-01-01), Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells Development, 144(6):1056-1064.
PMID: 28275009 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJ Yang et al. (2017-01-01), Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells Stem Cell Reports, 0(0).
PMID: 28262545 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayN Yucer et al. (2017-01-01), Directed Differentiation of Human Induced Pluripotent Stem Cells into Fallopian Tube Epithelium Sci Rep, 7(1):10741.
PMID: 28878359 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJ Jang et al. (2017-01-01), WNT/?-catenin pathway modulates the TNF-?-induced inflammatory response in bronchial epithelial cells Biochem. Biophys. Res. Commun, 0(0).
PMID: 28137581 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayPC Sanchez-Di et al. (2017-01-01), Ubiquitin carboxyl-terminal esterase L1 (UCHL1) is associated with stem-like cancer cell functions in pediatric high-grade glioma PLoS ONE, 12(5):e0176879.
PMID: 28472177 -
Species: Human
Sample Types: Whole Cells
Applications: BioassaySJ Zhao et al. (2017-01-01), SPARCL1 suppresses osteosarcoma metastasis and recruits macrophages by activation of canonical WNT/?-catenin signaling through stabilization of the WNT-receptor complex Oncogene, 0(0).
PMID: 29084211 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureH Xiao et al. (2017-01-01), A Novel Positive Feedback Loop Between NTSR1 and Wnt/?-Catenin Contributes to Tumor Growth of Glioblastoma Cell. Physiol. Biochem., 43(5):2133-2142.
PMID: 29065410 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayI Savvidou et al. (2017-01-01), Beta-catenin inhibitor BC2059 is efficacious as monotherapy or in combination with proteasome inhibitor bortezomib in multiple myeloma Mol. Cancer Ther., 0(0).
PMID: 28500235 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayV Uribe-Etxe et al. (2017-01-01), Notch/Wnt cross-signalling regulates stemness of dental pulp stem cells through expression of neural crest and core pluripotency factors Eur Cell Mater, 34(0):249-270.
PMID: 29092089 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayH Montacir et al. (2017-01-01), The N-glycome of embryonic stem cells and thereof differentiated hepatic cells Chembiochem, 0(0).
PMID: 28370937 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayK Low et al. (2017-01-01), Physico-electrochemical Characterization of Pluripotent Stem Cells during Self-Renewal or Differentiation by a Multi-modal Monitoring System Stem Cell Reports, 0(0).
PMID: 28457888 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJG Camp et al. (2017-01-01), Multilineage communication regulates human liver bud development from pluripotency Nature, 0(0).
PMID: 28614297 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayX Li et al. (2017-01-01), AKAP2 is upregulated in ovarian cancer, and promotes growth and migration of cancer cells Mol Med Rep, 0(0).
PMID: 28849175 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJ Jang et al. (2017-01-01), LPS-induced inflammatory response is suppressed by Wnt inhibitors, Dickkopf-1 and LGK974 Sci Rep, 7(0):41612.
PMID: 28128299 -
Species: Rat
Sample Types: Whole Cells
Applications: BioassayH Isshiki et al. (2017-01-01), Establishment of a refined culture method for rat colon organoids Biochem. Biophys. Res. Commun., 0(0).
PMID: 28559141 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayS Premarathn et al. (2017-01-01), Loss of Usp9x disrupts cell adhesion, and components of the Wnt and Notch signaling pathways in neural progenitors Sci Rep, 7(1):8109.
PMID: 28808228 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayY Choudhury et al. (2017-01-01), Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity Sci Rep, 7(0):41238.
PMID: 28120901 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayXH Jiang et al. (2017-01-01), Effects of hepatitis C virus core protein and nonstructural protein 4B on the Wnt/?-catenin pathway BMC Microbiol., 17(1):124.
PMID: 28545480 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayS Miura et al. (2017-01-01), Generation of Mouse and Human Organoid-Forming Intestinal Progenitor Cells by Direct Lineage Reprogramming Cell Stem Cell, 0(0).
PMID: 28943029 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayDS Varghese et al. (2017-01-01), Effects of Aminoglycoside Antibiotics on Human Embryonic Stem Cell Viability during Differentiation In Vitro Stem Cells Int, 2017(0):2451927.
PMID: 29147115 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayF Ou et al. (2017-01-01), The LncRNA ZBED3-AS1 induces chondrogenesis of human synovial fluid mesenchymal stem cells Biochem. Biophys. Res. Commun., 487(2):457-463.
PMID: 28431932 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayQ Gu et al. (2017-01-01), Accreditation of Biosafe Clinical-Grade Human Embryonic Stem Cells According to Chinese Regulations Stem Cell Reports, 0(0).
PMID: 28506532 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayIT Cho et al. (2017-01-01), Aristaless Related Homeobox (ARX) Interacts with ?-Catenin, BCL9, and P300 to Regulate Canonical Wnt Signaling PLoS ONE, 12(1):e0170282.
PMID: 28103279 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJJ Kathiriya et al. (2017-01-01), Galectin-1 inhibition attenuates profibrotic signaling in hypoxia-induced pulmonary fibrosis Cell Death Discov, 3(0):17010.
PMID: 28417017 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayY Kishimoto et al. (2017-01-01), Wnt/?-catenin signaling suppresses expressions of Scx, Mkx, and Tnmd in tendon-derived cells PLoS ONE, 12(7):e0182051.
PMID: 28750046 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayJ Messéant et al. (2017-01-01), Wnts contribute to neuromuscular junction formation through distinct signaling pathways Development, 0(0).
PMID: 28348167 -
Species: Rat
Sample Types: Whole Cells
Applications: BioassayML Xu et al. (2017-01-01), Wnt3a Induces the Expression of Acetylcholinesterase during Osteoblast Differentiation via the Runx2 Transcription Factor J. Biol. Chem., 0(0).
PMID: 28607150 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayCY Janda et al. (2017-01-01), Surrogate Wnt agonists that phenocopy canonical Wnt and ?-catenin signalling Nature, 0(0).
PMID: 28467818 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayT Nakamura et al. (2017-01-01), Age-related increase in Wnt inhibitor causes a senescence-like phenotype in human cardiac stem cells Biochem. Biophys. Res. Commun., 0(0).
PMID: 28435069 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJA Heslop et al. (2017-01-01), Donor-Dependent and Other Nondefined Factors Have Greater Influence on the Hepatic Phenotype Than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte-Like Cells Stem Cells Transl Med, 6(5):1321-1331.
PMID: 28456008 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayS Monteagudo et al. (2017-01-01), DOT1L safeguards cartilage homeostasis and protects against osteoarthritis Nat Commun, 8(0):15889.
PMID: 28627522 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayKB McCauley et al. (2017-01-01), Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling Cell Stem Cell, 0(0).
PMID: 28366587 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayDM Velázquez et al. (2017-01-01), Dishevelled stability is positively regulated by PKC?-mediated phosphorylation induced by Wnt agonists Cell. Signal., 35(0):107-117.
PMID: 28366812 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayB Lucendo-Vi et al. (2017-01-01), Modelling foetal exposure to maternal smoking using hepatoblasts from pluripotent stem cells Arch. Toxicol., 0(0).
PMID: 28510779 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayS Zeng et al. (2017-01-01), Wnt/?-catenin signaling contributes to tumor malignancy and is targetable in gastrointestinal stromal tumor Mol. Cancer Ther., 0(0).
PMID: 28611108 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureYukihiro Saito et al. (2017-01-01), Suppression of Wnt Signaling and Osteogenic Changes in Vascular Smooth Muscle Cells by Eicosapentaenoic Acid. Nutrients, 0(0):2072-6643.
PMID: 28796175 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayN Arora et al. (2017-01-01), A process engineering approach to increase organoid yield Development, 144(6):1128-1136.
PMID: 28174251 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassay(2016-01-01), Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins Proc. Natl. Acad. Sci. U.S.A, 0(0).
PMID: 28028233 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassay(2016-01-01), Activation of endothelial ?-catenin signaling induces heart failure Sci Rep, 6(0):25009.
PMID: 27146149 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassay(2016-01-01), Modeling Smith-Lemli-Opitz syndrome with induced pluripotent stem cells reveals a causal role for Wnt/?-catenin defects in neuronal cholesterol synthesis phenotypes Nat. Med., 22(4):388-96.
PMID: 26998835 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassay(2016-01-01), TNIK inhibition abrogates colorectal cancer stemness Nat Commun, 7(0):12586.
PMID: 27562646 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassay(2016-01-01), The AKAP GSKIP regulates beta-catenin through both its interactions with PKA and GSK3beta J Biol Chem, 0(0).
PMID: 27484798 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassay(2016-01-01), PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells Sci Rep, 6(0):36795.
PMID: 27827428 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayElena Neumann (2016-01-01), Expression of adipokines in osteoarthritis osteophytes and their effect on osteoblasts Matrix Biol., 0(0).
PMID: 27884778 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayKarthikeyan Mythreye (2016-01-01), Altering the Proteoglycan State of Transforming Growth Factor ? Type III Receptor (T?RIII)/Betaglycan Modulates Canonical Wnt/?-Catenin Signaling J. Biol. Chem., 291(49):25716-25728.
PMID: 27784788 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayRonald A DePinho (2016-01-01), Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth Cell, 167(5):1281-1295.e18.
PMID: 27863244 -
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay(2016-01-01), Quantifying ?-catenin subcellular dynamics and cyclin D1 mRNA transcription during Wnt signaling in single living cells Elife, 5(0).
PMID: 27879202 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayRichard P Phipps (2016-01-01), The Aryl Hydrocarbon Receptor and Its Ligands Inhibit Myofibroblast Formation and Activation: Implications for Thyroid Eye Disease Am. J. Pathol., 0(0).
PMID: 27842700 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayHoeke A Baarsma (2016-01-01), Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD J. Exp. Med, 0(0).
PMID: 27979969 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassay(2016-01-01), ROCK inhibitor primes human induced pluripotent stem cells to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation Stem Cell Res, 17(2):222-227.
PMID: 27591478 -
Species: Bovine
Sample Types: Whole Cells
Applications: BioassayL J Spicer (2016-01-01), G protein-coupled receptor 34 in ovarian granulosa cells of cattle: changes during follicular development and potential functional implications Domest. Anim. Endocrinol, 59(0):90-99.
PMID: 28040605 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayA Persad et al. (2016-01-01), Active ?-catenin is regulated by the PTEN/PI3 kinase pathway: a role for protein phosphatase PP2A Genes Cancer, 7(12):368-382.
PMID: 28191283 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassay(2016-01-01), Growth hormone is permissive for neoplastic colon growth Proc Natl Acad Sci USA, 0(0).
PMID: 27226307 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassay(2016-01-01), Wnt signaling promotes breast cancer by blocking ITCH-mediated degradation of the YAP/TAZ transcriptional coactivator WBP2 Cancer Res, 0(0).
PMID: 27578003 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassay(2016-01-01), Anthelmintic niclosamide disrupts the interplay of p65 and FOXM1/?-catenin and eradicates leukemia stem cells in chronic myelogenous leukemia Clin Cancer Res, 0(0).
PMID: 27492973 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayGui-Li Huang (2016-01-01), Oncogenic retinoic acid receptor ? promotes human colorectal cancer growth through simultaneously regulating p21 transcription and GSK3?/?-catenin signaling Cancer Lett, 388(0):118-129.
PMID: 27932034 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassay(2016-01-01), Tumor-Free Transplantation of Patient-Derived Induced Pluripotent Stem Cell Progeny for Customized Islet Regeneration Stem Cells Transl Med, 5(5):694-702.
PMID: 26987352 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayJunhua Wang et al. (2016-01-01), Icariin attenuates titanium-particle inhibition of bone formation by activating the Wnt/?-catenin signaling pathway in vivo and in vitro. Scientific Reports, 0(0):2045-2322.
PMID: 27029606 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJames M et al. (2015-01-01), Characterization and propagation of tumor initiating cells derived from colorectal liver metastases: trials, tribulations and a cautionary note. PLoS ONE, 10(2):e0117776.
PMID: 25658706 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayViale-Bouroncle S et al. (2015-01-01), A protein kinase A (PKA)/beta-catenin pathway sustains the BMP2/DLX3-induced osteogenic differentiation in dental follicle cells (DFCs). Cell Signal, 27(3):598-605.
PMID: 25530217 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayGrigson E et al. (2015-01-01), Canonical Wnt pathway inhibitor ICG-001 induces cytotoxicity of multiple myeloma cells in Wnt-independent manner. PLoS ONE, 10(1):e0117693.
PMID: 25635944 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayTesfay L et al. (2015-01-01), Hepcidin regulation in prostate and its disruption in prostate cancer. Cancer Res, 75(11):2254-63.
PMID: 25858146 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayWilliams K et al. (2015-01-01), Focal adhesion kinase and Wnt signaling regulate human ductal carcinoma in situ stem cell activity and response to radiotherapy. Stem Cells, 33(2):327-41.
PMID: 25187396 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayHuang T et al. (2015-01-01), A Regulatory Network Involving beta-Catenin, e-Cadherin, PI3k/Akt, and Slug Balances Self-Renewal and Differentiation of Human Pluripotent Stem Cells In Response to Wnt Signaling. Stem Cells, 33(5):1419-33.
PMID: 25538040 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayXue J et al. (2015-01-01), Tumour suppressor TRIM33 targets nuclear beta-catenin degradation. Nat Commun, 6(0):6156.
PMID: 25639486 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayHandorf A et al. (2015-01-01), Endogenously produced Indian Hedgehog regulates TGFbeta-driven chondrogenesis of human bone marrow stromal/stem cells. Stem Cells Dev, 24(8):995-1007.
PMID: 25519748 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayTamminen K et al. (2015-01-01), Intestinal Commitment and Maturation of Human Pluripotent Stem Cells Is Independent of Exogenous FGF4 and R-spondin1. PLoS ONE, 10(7):e0134551.
PMID: 26230325 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayMaubant S et al. (2015-01-01), Transcriptome analysis of wnt3a-treated triple-negative breast cancer cells. PLoS ONE, 10(4):e0122333.
PMID: 25848952 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayWong et al. (2015-01-01), Efficient generation of functional CFTR-expressing airway epithelial cells from human pluripotent stem cells. Nat Protoc, 10(3):363-81.
PMID: 25654755 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayKuhnl A et al. (2015-01-01), Downregulation of the Wnt inhibitor CXXC5 predicts a better prognosis in acute myeloid leukemia. Blood, 125(19):2985-94.
PMID: 25805812 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayZanni R et al. (2015-01-01), Novel cancer chemotherapy hits by molecular topology: dual Akt and Beta-catenin inhibitors. PLoS ONE, 10(4):e0124244.
PMID: 25910265 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayTsankov et al. (2015-01-01), Transcription factor binding dynamics during human ES cell differentiation. Nature, 518(7539):344-9.
PMID: 25693565 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayIyer D et al. (2015-01-01), Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells. Development, 142(8):1528-41.
PMID: 25813541 -
Peng H et al. (2015-01-01), microRNA-103/107 Family Regulates Multiple Epithelial Stem Cell Characteristics. Stem Cells, 33(5):1642-56.
PMID: 25639731 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayChang B et al. (2015-01-01), Epsin is required for Dishevelled stability and Wnt signalling activation in colon cancer development. Nat Commun, 6(0):6380.
PMID: 25871009 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayKim M et al. (2015-01-01), Activin-A and Bmp4 levels modulate cell type specification during CHIR-induced cardiomyogenesis. PLoS ONE, 10(2):e0118670.
PMID: 25706534 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayHuang S et al. (2015-01-01), The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells. Nat Protoc, 10(3):413-25.
PMID: 25654758 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayPezzolla D et al. (2015-01-01), Resveratrol ameliorates the maturation process of beta-cell-like cells obtained from an optimized differentiation protocol of human embryonic stem cells. PLoS ONE, 10(3):e0119904.
PMID: 25774684 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayListerman I et al. (2014-01-01), An investigation of the effects of the core protein telomerase reverse transcriptase on Wnt signaling in breast cancer cells. Mol Cell Biol, 34(2):280-9.
PMID: 24216762 -
Cnossen W et al. (2014-01-01), Whole-exome sequencing reveals LRP5 mutations and canonical Wnt signaling associated with hepatic cystogenesis. Proc Natl Acad Sci U S A, 111(14):5343-8.
PMID: 24706814 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayGuezguez A et al. (2014-01-01), Modulation of stemness in a human normal intestinal epithelial crypt cell line by activation of the WNT signaling pathway. Exp Cell Res, 322(2):355-64.
PMID: 24534551 -
Species: Human
Sample Types: Whole Cells
Applications: BioassaySundaram S et al. (2014-01-01), Tissue-engineered vascular grafts created from human induced pluripotent stem cells. Stem Cells Transl Med, 3(12):1535-43.
PMID: 25378654 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassayvan den Bosch M et al. (2014-01-01), Canonical Wnt signaling skews TGF-beta signaling in chondrocytes towards signaling via ALK1 and Smad 1/5/8. Cell Signal, 26(5):951-8.
PMID: 24463008 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayNakamura I et al. (2014-01-01), Brivanib attenuates hepatic fibrosis in vivo and stellate cell activation in vitro by inhibition of FGF, VEGF and PDGF signaling. PLoS ONE, 9(4):e92273.
PMID: 24710173 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayMeinhardt G et al. (2014-01-01), Wnt-dependent T-cell factor-4 controls human etravillous trophoblast motility. Endocrinology, 155(5):1908-20.
PMID: 24605829 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayHirata et al. (2014-01-01), Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation. Nat Commun, 5(0):4806.
PMID: 25254944 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayPeng X et al. (2014-01-01), Wnt/beta-catenin signaling regulates the proliferation and differentiation of mesenchymal progenitor cells through the p53 pathway. PLoS ONE, 9(5):e97283.
PMID: 24819053 -
Species: Rat
Sample Types: Whole Cells
Applications: BioassayTsai T et al. (2014-01-01), Pigment epithelium-derived factor 34-mer peptide prevents liver fibrosis and hepatic stellate cell activation through down-regulation of the PDGF receptor. PLoS ONE, 9(4):e95443.
PMID: 24763086 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayPethe et al. (2014-01-01), Polycomb group protein expression during differentiation of human embryonic stem cells into pancreatic lineage in vitro. BMC Cell Biol, 15(0):18.
PMID: 24885493 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayHwang Y et al. (2014-01-01), WNT3A promotes myogenesis of human embryonic stem cells and enhances in vivo engraftment. Sci Rep, 4(0):5916.
PMID: 25084050 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayLin P et al. (2014-01-01), A synthetic peptide-acrylate surface for production of insulin-producing cells from human embryonic stem cells. Stem Cells Dev, 23(4):372-9.
PMID: 24083371 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayEkstrom E et al. (2014-01-01), WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells. Mol Cancer, 13(0):88.
PMID: 24766647 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJin R et al. (2014-01-01), The metastasis suppressor NDRG1 modulates the phosphorylation and nuclear translocation of beta-catenin through mechanisms involving FRAT1 and PAK4. J Cell Sci, 127(0):3116-30.
PMID: 24829151 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayLin et al. (2014-01-01), Suppression of the SOX2 neural effector gene by PRDM1 promotes human germ cell fate in embryonic stem cells. Stem Cell Reports, 2(2):189-204.
PMID: 24527393 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayHinton A et al. (2014-01-01), sRNA-seq analysis of human embryonic stem cells and definitive endoderm reveals differentially expressed microRNAs and novel IsomiRs with distinct targets. Stem Cells, 32(9):2360-72.
PMID: 24805944 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayTodaro M et al. (2014-01-01), CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis. Cell Stem Cell, 14(3):342-56.
PMID: 24607406 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayEmmrich S et al. (2014-01-01), miR-99a/100~125b tricistrons regulate hematopoietic stem and progenitor cell homeostasis by shifting the balance between TGFbeta and Wnt signaling. Genes Dev, 28(8):858-74.
PMID: 24736844 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayCarmon K et al. (2014-01-01), RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. Proc Natl Acad Sci U S A, 111(13):E1221-9.
PMID: 24639526 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayCechin S et al. (2014-01-01), Influence of in vitro and in vivo oxygen modulation on beta cell differentiation from human embryonic stem cells. Stem Cells Transl Med, 3(3):277-89.
PMID: 24375542 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayMassumi M et al. (2014-01-01), Efficient programming of human eye conjunctiva-derived induced pluripotent stem (ECiPS) cells into definitive endoderm-like cells. Exp Cell Res, 322(1):51-61.
PMID: 24434355 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayLam A et al. (2014-01-01), Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers. J Am Soc Nephrol, 25(6):1211-25.
PMID: 24357672 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayChen E et al. (2014-01-01), Glycogen synthase kinase 3 inhibitors induce the canonical WNT/beta-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma. Proc Natl Acad Sci U S A, 111(14):5349-54.
PMID: 24706870 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayAloia L et al. (2014-01-01), Zrf1 is required to establish and maintain neural progenitor identity. Genes Dev, 28(2):182-97.
PMID: 24449271 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayKang et al. (2014-01-01), Generation of bladder urothelium from human pluripotent stem cells under chemically defined serum- and feeder-free system. Int J Mol Sci, 15(5):7139-57.
PMID: 24776760 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayKang et al. (2014-01-01), Differentiation of human pluripotent stem cells into nephron progenitor cells in a serum and feeder free system. PLoS ONE, 9(4):e94888.
PMID: 24728509 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayDhamdhere et al. (2014-01-01), Drugging a stem cell compartment using Wnt3a protein as a therapeutic. PLoS ONE, 9(1):e83650.
PMID: 24400074 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJabaji Z et al. (2014-01-01), Type I collagen as an extracellular matrix for the in vitro growth of human small intestinal epithelium. PLoS ONE, 9(9):e107814.
PMID: 25222024 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayFuerer C et al. (2014-01-01), Nodal.Gdf1 heterodimers with bound prodomains enable serum-independent nodal signaling and endoderm differentiation. J Biol Chem, 289(25):17854-71.
PMID: 24798330 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayHillesheim A et al. (2014-01-01), beta-catenin promotes the type I IFN synthesis and the IFN-dependent signaling response but is suppressed by influenza A virus-induced RIG-I/NF-kappaB signaling. Cell Commun Signal, 12(0):29.
PMID: 24767605 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayKilander M et al. (2014-01-01), Assessment of Frizzled 6 membrane mobility by FRAP supports G protein coupling and reveals WNT-Frizzled selectivity. Cell Signal, 26(9):1943-9.
PMID: 24873871 -
Species: Porcine
Sample Types: Whole Cells
Applications: BioassayAo et al. (2014-01-01), High efficient differentiation of functional hepatocytes from porcine induced pluripotent stem cells. PLoS ONE, 9(6):e100417.
PMID: 24949734 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayLee J et al. (2014-01-01), Interleukin-1beta-induced Wnt5a enhances human corneal endothelial cell migration through regulation of Cdc42 and RhoA. Mol Cell Biol, 34(18):3535-45.
PMID: 25022753 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayCecchelli R et al. (2014-01-01), A stable and reproducible human blood-brain barrier model derived from hematopoietic stem cells. PLoS ONE, 9(6):e99733.
PMID: 24936790 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayTsai H et al. (2014-01-01), Wnts enhance neurotrophin-induced neuronal differentiation in adult bone-marrow-derived mesenchymal stem cells via canonical and noncanonical signaling pathways. PLoS ONE, 9(8):e104937.
PMID: 25170755 -
Wu C et al. (2014-01-01), RSPO2-LGR5 signaling has tumour-suppressive activity in colorectal cancer. Nat Commun, 5(0):3149.
PMID: 24476626 -
Species: Human
Sample Types: Whole Tissue
Applications: BioassaySkoczek D et al. (2014-01-01), Luminal microbes promote monocyte-stem cell interactions across a healthy colonic epithelium. J Immunol, 193(1):439-51.
PMID: 24907348 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayHernandez-Maqueda J et al. (2013-01-01), Protein kinase C delta negatively modulates canonical Wnt pathway and cell proliferation in colon tumor cell lines. PLoS ONE, 8(3):e58540.
PMID: 23520519 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayRasmussen N et al. (2013-01-01), Receptor tyrosine kinase-like orphan receptor 2 (Ror2) expression creates a poised state of Wnt signaling in renal cancer. J Biol Chem, 288(36):26301-10.
PMID: 23893409 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureGoto T et al. (2013-01-01), IQGAP1 protein regulates nuclear localization of beta-catenin via importin-beta5 protein in Wnt signaling. J Biol Chem, 288(51):36351-60.
PMID: 24196961 -
Jiang Y et al. (2013-01-01), Activation of the Wnt pathway through AR79, a GSK3beta inhibitor, promotes prostate cancer growth in soft tissue and bone. Mol Cancer Res, 11(12):1597-610.
PMID: 24088787 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayRezania A et al. (2013-01-01), Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo. Stem Cells, 31(11):2432-42.
PMID: 23897760 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassay(2013-01-01), Cripto-1 enhances the canonical Wnt/β-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors. Cell Signal, 25(1):178-89.
PMID: 23022962 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayLoh Y et al. (2013-01-01), The Wnt signalling pathway is upregulated in an in vitro model of acquired tamoxifen resistant breast cancer. BMC Cancer, 13(0):174.
PMID: 23547709 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayGreer Y et al. (2013-01-01), Atypical protein kinase Ciota is required for Wnt3a-dependent neurite outgrowth and binds to phosphorylated dishevelled 2. J Biol Chem, 288(13):9438-46.
PMID: 23396968 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayHannan et al. (2013-01-01), Generation of multipotent foregut stem cells from human pluripotent stem cells. Stem Cell Reports, 1(4):293-306.
PMID: 24319665 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayThatava T et al. (2013-01-01), Intrapatient variations in type 1 diabetes-specific iPS cell differentiation into insulin-producing cells. Mol Ther, 21(1):228-39.
PMID: 23183535 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayTahir S et al. (2013-01-01), Caveolin-1-LRP6 signaling module stimulates aerobic glycolysis in prostate cancer. Cancer Res, 73(6):1900-11.
PMID: 23302227 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayWilson TR et al. (2012-01-01), Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 487(7408):505-9.
PMID: 22763448 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayCohen E et al. (2012-01-01), Wnt5a and Wnt11 are essential for second heart field progenitor development. Development, 139(11):1931-40.
PMID: 22569553 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayErceg S et al. (2012-01-01), Derivation of cerebellar neurons from human pluripotent stem cells. Curr Protoc Stem Cell Biol, 20(0):1H.51.
PMID: 22415839 -
Species: Human
Sample Types: Whole Cells
Applications: BioassaySui L et al. (2012-01-01), FGF signaling via MAPK is required early and improves Activin A-induced definitive endoderm formation from human embryonic stem cells. Biochem Biophys Res Commun, 426(3):380-5.
PMID: 22960178 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayIchii et al. (2012-01-01), The canonical Wnt pathway shapes niches supportive of hematopoietic stem/progenitor cells. Blood, 119(7):1683-92.
PMID: 22117039 -
Species: Bovine
Sample Types: Whole Cells
Applications: BioassayAad et al. (2012-01-01), The hedgehog system in ovarian follicles of cattle selected for twin ovulations and births: evidence of a link between the IGF and hedgehog systems. Biol Reprod, 87(4):79.
PMID: 22811575 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CulturePrabakar K et al. (2012-01-01), Generation of glucose-responsive, insulin-producing cells from human umbilical cord blood-derived mesenchymal stem cells. Cell Transplant, 21(6):1321-39.
PMID: 22195604 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayKohler EE et al. (2011-01-01), NANOG induction of fetal liver kinase-1 (FLK1) transcription regulates endothelial cell proliferation and angiogenesis. Blood, 117(5):1761-9.
PMID: 21119109 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayLiu N et al. (2011-01-01), High levels of beta-catenin signaling reduce osteogenic differentiation of stem cells in inflammatory microenvironments through inhibition of the noncanonical Wnt pathway. J. Bone Miner. Res., 26(9):2082-95.
PMID: 21638320 -
Species: Human
Sample Types: Whole Cells
Applications: BioassaySpence JR et al. (2011-01-01), Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature, 470(7332):105-9.
PMID: 21151107 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayGudjonsson JE et al. (2010-01-01), Evidence for altered Wnt signaling in psoriatic skin. J. Invest. Dermatol., 130(7):1849-59.
PMID: 20376066 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayLiu G et al. (2009-01-01), Canonical Wnts function as potent regulators of osteogenesis by human mesenchymal stem cells. J. Cell Biol., 185(1):67-75.
PMID: 19349579 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayHenry C et al. (), Targeting the ROR1 and ROR2 receptors in epithelial ovarian cancer inhibits cell migration and invasion. Oncotarge6(37):40310-26.
PMID: 26515598
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Customer Reviews for Recombinant Human Wnt-3a Protein (25)
Customer Images
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Application: Cell migration/motilityVerified Customer | Posted 05/20/2023wnt3a promote wound healing.
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Application: Stem/Immune cell maintenance or differentiationVerified Customer | Posted 01/01/2022wnt3a was used for the differentiation of cerebral organoid
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Application: CellProlifVerified Customer | Posted 11/29/2021avoid freezing and refreezing.
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Application: Stem/Immune cell maintenance or differentiationVerified Customer | Posted 09/26/2021
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Application: CellProlifVerified Customer | Posted 08/17/2021200ng/ml wn3a CF can further promote the colony formation efficiency.
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Application: Stem/Immune cell maintenance or differentiationVerified Customer | Posted 08/17/2021
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Application: Enzymatic activity in vitroReason for Rating: excellent product, very repeated product, we bought it many times with different lot numbersVerified Customer | Posted 08/06/2021
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Application: CellProlifReason for Rating: This product works good.Verified Customer | Posted 07/20/2021Use the final concentration that is recommended, don't make the final concentration very low. Hek293SFT cells were treated with different concentrations of wnt3a, and topflash assay was performed to detect the luciferase activity of wnt3a.
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Application: Cell CultureVerified Customer | Posted 01/02/2021
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Application: Enzymatic activity in vitroVerified Customer | Posted 11/06/2020HepG2 cells were treated with 100 ng/ml Wnt3a for 2 days, following which the LDH activity of cell culture medium samples were assayed. The result shows that Wnt3a increased LDH release in HepG2 cells.
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Application: SDS-PAGE ControlReason for Rating: Recombinant Wnt3a product was added to activate Wnt/ beta -catenin signaling pathway.Verified Customer | Posted 02/16/2020
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Application: In vitro bioactivity in cell cultureReason for Rating: This protein (200 ng/mL) works well for activating Wnt signaling as shown by Topflash luciferase activity.Verified Customer | Posted 12/16/2018
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Application: In vitro bioactivity in cell cultureReason for Rating: The product worked to activate Wnt signaling in breast cancer cells with a Wnt reporter, however performed less well than supernatants from L cell Wnt3a lines.Verified Customer | Posted 10/27/2018Recombinant Wnt3a product was added at 100 ng/mL for 2 days on 7TGC reporter cell lines. Activation was measured with GFP levels by Flow.
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Application: CellProlifVerified Customer | Posted 10/17/2018
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Application: In vitro bioactivity in cell cultureVerified Customer | Posted 12/06/2017
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Application: In vitro bioactivity in cell cultureVerified Customer | Posted 06/07/2017
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Application: Cell migration/motilityVerified Customer | Posted 03/14/2017Cell motility assay performed with MA-11 cells untreated (A) and treated (B) for 72 hours with R&D Recombinant Human Wnt-3a (#5036-WN/CF) at 250 ng/mL.
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Application: Stem/Immune cell maintenance or differentiationVerified Customer | Posted 12/15/2016We use for stem cell maintenance and differentiation.
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Application: Stem/Immune cell maintenance or differentiationVerified Customer | Posted 12/15/2016We use this product for our neuron stem cells studies.
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Application: In vitro bioactivity in cell cultureReason for Rating: It works well.Verified Customer | Posted 11/11/2016I tested the activity of the recombinant protein in the HEK293 Top Flash Reporter cell lines. LiCl was used as a positive control.
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Application: Luciferase reporter activity (TOPFlash for Wnt activity) was performed in cultured cells.Verified Customer | Posted 08/08/2016Luciferase reporter activity by TOPFlash/FOPFlash for Wnt/B-catenin activity was performed in cultured cells. Cells were transfected for 48 hours with plasmid and treated with Wnt3a for 24 hours prior to performing Dual-Glo luciferase assay.
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Application: Stem/Immune cell maintenance or differentiationReason for Rating: We attempted to use the product to induce skeletal muscle differentiation in Mus musculus stem cells, but our results suggest differentiation to cardiomyocytes.Verified Customer | Posted 05/13/2016
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Application: CellProlifVerified Customer | Posted 01/15/2016
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Application: SDS-PAGE ControlReason for Rating: I have used Wnt3a routinely to stimulate primary cells in culture. I have obtained consistent results with reproducible data.Verified Customer | Posted 01/13/2016
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Application: Media additive for protein or antibody productionReason for Rating: This protein works very well for activating Wnt signaling as shown by B-catenin expression.Verified Customer | Posted 01/13/2016
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FAQs for Recombinant Human Wnt-3a Protein
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Can I reconstitute Recombinant Human Wnt-3a Protein (catalog # 5036-WN) at a different concentration than recommended?
We cannot guarantee the performance if the protein is reconstituted at a different concentration than recommended in the product datasheet. Please contact Technical Service if you have any questions or concerns about reconstitution.
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Can I reconstitute Recombinant Human Wnt-3a Protein (catalog # 5036-WN) in a different buffer than recommended?
For best recovery, stability, and activity, the protein should be reconstituted in the buffer recommended on the product datasheet. Stability testing has been evaluated under these conditions; we can support the performance under these reconstitution conditions.