What is the half life of Recombinant Human Noggin Protein (Catalog # 6057-NG) in vitro?

Recombinant Human Noggin Protein (Catalog # 6057-NG) is evaluated for bioactivity by its ability to inhibit BMP-4-induced alkaline phosphatase production in mouse chondrogenic cells in vitro. We have not evaluated the half-life of 6057-NG. The half-life of a specific protein will depend on experimental conditions, including the cell number, density, and media content. It is up to the end-users to determine the appropriate concentration and timing when adding 6057-NG to individual experiments. For techniques and methodologies, we recommend reviewing our list of publications under the Citations tab on the product-specific web page to find reported use of our products in similar experimental layouts.

Has Recombinant Human Noggin Protein (Catalog # 6057-NG or 6057-NG/CF) been evaluated in vivo?

Recombinant Human Noggin Protein (Catalog # 6057-NG) is evaluated for bioactivity by its ability to inhibit BMP-4-induced alkaline phosphatase production in mouse chondrogenic cells in vitro. We have not evaluated this protein for activity in vivo, but we are aware of publications citing use of the protein this type of experimentation. We recommend reviewing our list of publications under the Citations tab on the product-specific web page to find reported use of our products in similar experimental layouts.

Recombinant Human Noggin Protein

Name: Recombinant Human Noggin Protein
Brand: R&D Systems
SKU: 6057-NG
Rating: 5 (8 reviews)

R&D Systems, Inc. a Bio-Techne Brand

Catalog # 6057-NG

Citations (174)

(8)

Product Datasheet / COA / SDS

Catalog #

Availability

Size / Price

Qty

Setting the standard in quality research reagents

Key Product Details

Source:	NS0
Accession #:	Q13253
Structure / Form:	Disulfide-linked homodimer
Applications:	Bioactivity

View Full Technical Details for Recombinant Human Noggin Protein

Product Specifications for Recombinant Human Noggin Protein

Source	Mouse myeloma cell line, NS0-derived human Noggin protein Gln28-Cys232
Purity	>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin level	<0.10 EU per 1 μg of the protein by the LAL method.
N-terminal sequence Analysis	No results obtained: Gln28 predicted
Predicted Molecular Mass	23 kDa (monomer)
SDS-PAGE	30-33 kDa, reducing conditions
Activity	Measured by its ability to inhibit BMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED₅₀ for this effect is 0.0200-0.160 μg/mL in the presence of 50 ng/mL of Recombinant Human BMP‑4 (Catalog # 314-BP).

Scientific Data Examples for Recombinant Human Noggin Protein

	Superior and Consistent Pluripotent Stem Cell Differentiation with R&D Systems Recombinant Human Noggin. BG01V human embryonic stem cells were cultured in Mouse Embryonic Fibroblast Conditioned Media supplemented with FGF basic (5 ng/mL). Stem cells were driven into early cells of the neuroectoderm using a 3 day incubation in recombinant human Noggin (25 µg/mL) from either R&D Systems (Lot 1, Lot 2; Catalog # 6057-NG) or from two separate competitors (Competitor 1, Competitor 2). Control cells were not incubated in Noggin (No Noggin). The cells were stained for the early ectoderm marker, Otx2, and the neuroectoderm marker, SOX1. (A) Representative images of SOX1 (green), Otx2 (red), and DAPI (blue) staining in embryonic stem cells differentiated with Noggin from R&D Systems or Noggin from Competitor 2. (B) SOX1+ clusters were quantified under each of the indicated culture conditions. Cells treated with R&D Systems Noggin showed an increase in SOX1+ cells compared to both untreated and competitor-treated cells. R&D Systems Noggin showed consistent differentiation across the lots tested. BG01V human embryonic stem cells are licensed from ViaCyte, Inc.
	Superior and Consistent Pluripotent Stem Cell Differentiation with R&D Systems Recombinant Human Noggin. Recombinant Human Noggin (Catalog # 6057-NG) inhibits BMP-4 induced alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line. The activity is approximately 30-fold greater than the top competitor's Noggin.
	Recombinant Human Noggin Protein Lot-to-Lot Consistency The lot-to-lot consistency of Recombinant Human Noggin (Catalog # 6057-NG) was assessed by testing the ability of three independent lots of the protein to inhibit BMP-4-induced alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line (orange, green, red lines). Each trace on the graph represents data obtained from Recombinant Human Noggin from a different manufacturing run. The ED₅₀ for this effect is 0.020-0.160 ug/mL in the presence of 50 ng/mL Recombinant Human BMP-4 (314-BP). The dark blue line on the graph is showing the ability of Recombinant Human BMP-4 (ng/mL) to induce alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line.

Formulation, Preparation and Storage

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

6057-NG

Carrier

Formulation	Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution	Reconstitute at 250 μg/mL in PBS containing at least 0.1% human or bovine serum albumin.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

6057-NG/CF

Carrier Free

Formulation	Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution	Reconstitute at 250 μg/mL in PBS.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Background: Noggin

Noggin is a secreted homodimeric glycoprotein that is an antagonist of bone morphogenetic proteins (BMPs) (1, 2). Human Noggin cDNA encodes a 232 amino acid (aa) precursor protein; cleavage of a 19 aa signal peptide generates the 213 aa mature protein which contains an N-terminal acidic region, a central basic heparin‑binding segment and a C-terminal cysteine-knot structure (2). Secreted Noggin probably remains close to the cell surface due to its binding of heparin‑containing proteoglycans (3). Noggin is very highly conserved among vertebrates, such that mature human Noggin shares 99%, 99%, 98%, 97% and 89% aa sequence identity with mouse, rat, bovine, equine and chicken Noggin, respectively. Noggin binds some BMPs such as BMP-4 with high affinity and others such as BMP-7 with lower affinity. It antagonizes BMP bioactivities by blocking epitopes on BMPs that are needed for binding to both type I and type II receptors (2, 4). During embryogenesis, Noggin antagonizes specific BMPs at defined times, for example, during neural tube, somite and cardiomyocyte growth and patterning (5-7). During skeletal development, Noggin prevents chondrocyte hyperplasia, thus allowing proper formation of joints (4). Mutations within the cysteine-knot region of human Noggin are linked to multiple types of skeletal dysplasias that result in apical joint fusions (8). Noggin is expressed in defined areas of the adult central nervous system and peripheral tissues such as lung, skeletal muscle and skin (1). During culture of human embryonic stem cells (hESC) or neural stem cells under certain conditions, addition of Noggin to antagonize BMP activity may allow stem cells to proliferate while maintaining their undifferentiated state, or alternatively, to differentiate into dopaminergic neurons (6, 9 - 13). Noggin also appears to maintain adult stem cell populations in-vivo, for example, maintaining neural stem cells within the hippocampus (13).

Item	Value
References	Valenzuela, D.M. et al. (1995) J. Neurosci. 15:6077. Groppe, J. et al. (2002) Nature 420:636. Paine-Saunders, S et al. (2002) J. Biol. Chem. 277:2089. Brunet, L. J. et al. (1998) Science 280:1455. McMahon, J. A. et al. (1998) Genes Dev. 12:1438. Itsykson, P. et al. (2005) Mol. Cell. Neurosci. 30:24. Yuasa, S. et al. (2005) Nat. Biotechnol. 23:607. Gong, Y. et al. (1999) Nat. Genet. 21:302. Xu, R.-H. et al. (2005) Nat. Methods 2:185. Wang, G. et al. (2005) Biochem. Biophys. Res. Commun. 330:934. Chaturvedi, G. et al. (2009) Cell Prolif. 42:425. Chiba, S. et al. (2008) Stem Cells 26:2810. Bonaguidi, M.A. et al. (2008) J. Neurosci. 28:9194.
Entrez Gene IDs	9241 (Human); 18121 (Mouse)
Alternate Names	NOG, Noggin, SYM1, SYNS1, SYNS1A, symphalangism 1 (proximal), synostoses (multiple) syndrome 1

Citations for Recombinant Human Noggin Protein (174)

Showing 1 - 10 of 174 citations Showing All

Filter By:

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for Recombinant Human Noggin Protein include:

Species: Human
Sample Types: Whole Cells
Applications: Bioassay

K Uehara et al. (2022), Epithelial-derived factors induce muscularis mucosa of human induced pluripotent stem cell-derived gastric organoids Stem Cell Reports, 0(0).
PMID: 35245440
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

J Zhou et al. (2022), ATG7-mediated autophagy facilitates embryonic stem cell exit from naive pluripotency and marks commitment to differentiation Autophagy, 0(0).
PMID: 35311460
Species: Human
Sample Types: Organoid
Applications: Bioassay

S Vachenc et al. (2022), OncoSNIPEï¿½ Study Protocol, a study of molecular profiles associated with development of resistance in solid cancer patients BMC Cancer, 22(1):41.
PMID: 34991520
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

K Zhao et al. (2022), Intracameral Microimaging of Maturation of Human iPSC Derivatives into Islet Endocrine Cells Cell Transplantation, 31(0):9636897211066.
PMID: 35156411
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

JM Suárez-Riv et al. (2022), Pterostilbene in Combination With Mitochondrial Cofactors Improve Mitochondrial Function in Cellular Models of Mitochondrial Diseases Frontiers in Pharmacology, 13(0):862085.
PMID: 35370630
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Kim et al. (2022), Tissue extracellular matrix hydrogels as alternatives to Matrigel for culturing gastrointestinal organoids Nature Communications, 13(1):1692.
PMID: 35354790
Species: Human
Sample Types: Organoids
Applications: Bioassay

YH Go et al. (2022), Modeling Pancreatic Cancer with Patient-Derived Organoids Integrating Cancer-Associated Fibroblasts Cancers, 14(9).
PMID: 35565206
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay

S Ding et al. (2022), Patient-derived micro-organospheres enable clinical precision oncology Cell Stem Cell, 0(0).
PMID: 35508177
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

M Ohgushi et al. (2022), Delamination of trophoblast-like syncytia from the amniotic ectodermal analogue in human primed embryonic stem cell-based differentiation model Cell Reports, 39(12):110973.
PMID: 35732132
Species: Equine
Sample Types: Organoid
Applications: Bioassay

RE Thompson et al. (2022), Equine Oviductal Organoid Generation and Cryopreservation Methods and protocols, 5(3).
PMID: 35736552
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

K Kishimoto et al. (2022), Directed differentiation of human pluripotent stem cells into diverse organ-specific mesenchyme of the digestive and respiratory systems Nature Protocols, 0(0).
PMID: 35978039
Species: Frog

Applications: Bioassay

K Johnson et al. (2022), Quantitative analysis of transcriptome dynamics provides novel insights into developmental state transitions BMC Genomics, 23(1):723.
PMID: 36273135
Species: Human
Sample Types: Organoid
Applications: Bioassay

H Marei et al. (2022), Antibody targeting of E3 ubiquitin ligases for receptor degradation Nature, 610(7930):182-189.
PMID: 36131013
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

M Kuwahara et al. (2022), Fluvastatin promotes chondrogenic differentiation of adipose-derived mesenchymal stem cells by inducing bone morphogenetic protein 2 Bmc Pharmacology Toxicology, 2022;23(1):61.
PMID: 35945639
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

KJ Ng et al. (2022), Sox2 in the dermal papilla regulates hair follicle pigmentation Oncogene, 40(3):111100.
PMID: 35858560
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

E Akrioti et al. (2022), Early Signs of Molecular Defects in iPSC-Derived Neural Stems Cells from Patients with Familial Parkinson's Disease Biomolecules, 12(7).
PMID: 35883433
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

ESY Ng et al. (2022), Membrane Attack Complex Mediates Retinal Pigment Epithelium Cell Death in Stargardt Macular Degeneration Cells, 11(21).
PMID: 36359858
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Iannielli et al. (2022), Modeling native and seeded Synuclein aggregation and related cellular dysfunctions in dopaminergic neurons derived by a new set of isogenic iPSC lines with SNCA multiplications Cell Death Disease, 2022;13(10):881.
PMID: 36261424
Species: Feline
Sample Types: Organoids
Applications: Bioassay

RE Thompson et al. (2022), Generation and cryopreservation of feline oviductal organoids Theriogenology, 196(0):167-173.
PMID: 36423511
Species: N/A
Sample Types: Plasmid
Applications: Bioassay

V Haellman et al. (2021), Rational design and optimization of synthetic gene switches for controlling cell-fate decisions in pluripotent stem cells Metabolic engineering, 65(0):99-110.
PMID: 33744461
Species: Porcine
Sample Types: Organoids
Applications: Bioassay

B Vermeire et al. (2021), Porcine small intestinal organoids as a model to explore ETEC-host interactions in the gut Veterinary research, 52(1):94.
PMID: 34174960
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

N Brookhouse et al. (2021), APOE2 mitigates disease-related phenotypes in an isogenic hiPSC-based model of Alzheimer's disease Molecular Psychiatry, 0(0).
PMID: 33837271
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MDA Norman et al. (2021), Measuring the elastic modulus of soft culture surfaces and three-dimensional hydrogels using atomic force microscopy Nature Protocols, 0(0).
PMID: 33854255
Species: Equine
Sample Types: Organoid
Applications: Bioassay

S Hellman (2021), Generation of equine enteroids and enteroid-derived 2D monolayers that are responsive to microbial mimics Veterinary research, 52(1):108.
PMID: 34391473
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

T Bai et al. (2021), Establishment of human induced trophoblast stem-like cells from term villous cytotrophoblasts Stem Cell Research, 56(0):102507.
PMID: 34454392
Species: Human
Sample Types: Organoid
Applications: Bioassay

O Hoare et al. (2021), Exploring the Complementarity of Pancreatic Ductal Adenocarcinoma Preclinical Models Cancers, 13(10).
PMID: 34069519
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

M Ali et al. (2021), Pluripotent stem cell-derived corneal endothelial cells as an alternative to donor corneal endothelium in keratoplasty Stem Cell Reports, 0(0).
PMID: 34358452
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Merlevede et al. (2021), A quantitative model of cellular decision making in direct neuronal reprogramming Scientific Reports, 11(1):1514.
PMID: 33452356
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

N Yucer et al. (2021), Human iPSC-derived fallopian tube organoids with BRCA1 mutation recapitulate early-stage carcinogenesis Cell Reports, 37(13):110146.
PMID: 34965417
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

R Sharma et al. (2021), Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model Nature Communications, 12(1):7293.
PMID: 34911940
Species: Chicken
Sample Types: Whole Cells
Applications: Bioassay

B Orr et al. (2021), Novel chicken two-dimensional intestinal model comprising all key epithelial cell types and a mesenchymal sub-layer Veterinary research, 52(1):142.
PMID: 34819162
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Bruzelius et al. (2021), Reprogramming Human Adult Fibroblasts into GABAergic Interneurons Cells, 10(12).
PMID: 34943958
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

AK Eicher et al. (2021), Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells Cell Stem Cell, 0(0).
PMID: 34856121
Species: Human
Sample Types: Organoid
Applications: Bioassay

Y Cheng et al. (2021), Targeting uPA-uPAR interaction to improve intestinal epithelial barrier integrity in inflammatory bowel disease EBioMedicine, 75(0):103758.
PMID: 34933179
Species: Human
Sample Types: Organoid
Applications: Bioassay

R Nicolle et al. (2021), Relevance of biopsy-derived pancreatic organoids in the development of efficient transcriptomic signatures to predict adjuvant chemosensitivity in pancreatic cancer Translational Oncology, 16(0):101315.
PMID: 34906890
Species: Human
Sample Types: Organoid
Applications: Bioassay

V Chesnokova et al. (2021), Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage Cell Reports, 37(11):110068.
PMID: 34910915
Species: Human
Sample Types: Organoid
Applications: Bioassay

SK Sarvestani et al. (2021), Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity Nature Communications, 12(1):262.
PMID: 33431859
Species: Human
Sample Types: Organoid
Applications: Bioassay

BM Larsen et al. (2021), A pan-cancer organoid platform for precision medicine Cell Reports, 36(4):109429.
PMID: 34320344
Species: Human
Sample Types: Organoid
Applications: Bioassay

H Nakashima et al. (2021), MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling Cell Reports, 35(7):109124.
PMID: 34010654
Species: Human
Sample Types: Organoid
Applications: Bioassay

K Husain et al. (2021), Farnesyl dimethyl chromanol targets colon cancer stem cells and prevents colorectal cancer metastasis Scientific Reports, 11(1):2185.
PMID: 33500430
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Yoshida et al. (2020), Generation of intestinal organoids derived from human pluripotent stem cells for drug testing Sci Rep, 10(1):5989.
PMID: 32249832
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

A Gunne-Brad et al. (2020), GATA3 Mediates a Fast, Irreversible Commitment to BMP4-Driven Differentiation in Human Embryonic Stem Cells Cell Stem Cell, 26(5):693-706.e9.
PMID: 32302522
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

NK Vinckier et al. (2020), LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development Nat Commun, 11(1):2082.
PMID: 32350257
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

S Forostyak et al. (2020), Transplantation of Neural Precursors Derived from Induced Pluripotent Cells Preserve Perineuronal Nets and Stimulate Neural Plasticity in ALS Rats International Journal of Molecular Sciences, 21(24).
PMID: 33339362
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

L Han et al. (2020), Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis Nat Commun, 11(1):4158.
PMID: 32855417
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

AB Caldwell et al. (2020), Dedifferentiation and neuronal repression define familial Alzheimer's disease Sci Adv, 6(46).
PMID: 33188013
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

J Giacomoni et al. (2020), Direct Conversion of Human Stem Cell-Derived Glial Progenitor Cells into GABAergic Interneurons Cells, 9(11).
PMID: 33182669
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

K Lloyd et al. (2020), Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease Dis Model Mech, 0(0).
PMID: 32958515
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

J Meisig et al. (2020), Kinetic modeling of stem cell transcriptome dynamics to identify regulatory modules of normal and disturbed neuroectodermal differentiation Nucleic Acids Res, 0(0).
PMID: 33245762
Species: Human
Sample Types: Organoid
Applications: Bioassay

A Di Grazia et al. (2020), The Fragile X Mental Retardation Protein regulates RIP1K and colorectal cancer resistance to necroptosis Cell Mol Gastroenterol Hepatol, 0(0).
PMID: 33091622
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

L Zhang et al. (2020), Generation of Functional Brown Adipocytes from Human Pluripotent Stem Cells via Progression through a Paraxial Mesoderm State Cell Stem Cell, 0(0).
PMID: 32783886
Species: Human
Sample Types: Organoid
Applications: Bioassay

MJ Workman et al. (2020), Modeling Intestinal Epithelial Response to Interferon-&gamma in Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids International Journal of Molecular Sciences, 22(1).
PMID: 33396621
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Zheng et al. (2020), A microfluidics-based stem cell model of early post-implantation human development Nature Protocols, 0(0).
PMID: 33311712
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Nolbrant et al. (2020), Direct Reprogramming of Human Fetal- and Stem Cell-Derived Glial Progenitor Cells into Midbrain Dopaminergic Neurons Stem Cell Reports, 0(0).
PMID: 32976765
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

L Han et al. (2020), Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis Nat Commun, 11(1):4158.
PMID: 32855417
Species: Human
Sample Types: Organoid
Applications: Bioassay

L Zhang et al. (2020), Generation of Functional Brown Adipocytes from Human Pluripotent Stem Cells via Progression through a Paraxial Mesoderm State Cell Stem Cell, 0(0).
PMID: 32783886
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

J Ruzicka et al. (2019), The Effect of iPS-Derived Neural Progenitors Seeded on Laminin-Coated pHEMA-MOETACl Hydrogel with Dual Porosity in a Rat Model of Chronic Spinal Cord Injury Cell Transplant, 0(0):9636897188237.
PMID: 30654639
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

STJ Bradford et al. (2019), High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds J. Biol. Chem., 0(0).
PMID: 30602563
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

V Chesnokova et al. (2019), Excess growth hormone suppresses DNA damage repair in epithelial cells JCI Insight, 4(3).
PMID: 30728323
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

M Iwashita et al. (2019), Brain-stiffness-mimicking tilapia collagen gel promotes the induction of dorsal cortical neurons from human pluripotent stem cells Sci Rep, 9(1):3068.
PMID: 30816128
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

AR Field et al. (2019), Structurally Conserved Primate LncRNAs Are Transiently Expressed during Human Cortical Differentiation and Influence Cell-Type-Specific Genes Stem Cell Reports, 12(2):245-257.
PMID: 30639214
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TR Broda et al. (2019), Generation of human antral and fundic gastric organoids from pluripotent stem cells Nat Protoc, 14(1):28-50.
PMID: 30470820
Species: Human
Sample Types: Whole Cells
Applications: Differentiation

X Wang et al. (2019), Point mutations in the PDX1 transactivation domain impair human ?-cell development and function Mol Metab, 0(0).
PMID: 30930126
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay

AJ Miller et al. (2019), Generation of lung organoids from human pluripotent stem cells in vitro Nat Protoc, 14(2):518-540.
PMID: 30664680
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

AM Blázquez-M et al. (2019), Noggin depletion in adipocytes promotes obesity in mice Mol Metab, 0(0).
PMID: 31027994
Species: Human
Sample Types: Organoid
Applications: Bioassay

KB Jung et al. (2019), Blockade of STAT3 Causes Severe In Vitro and In Vivo Maturation Defects in Intestinal Organoids Derived from Human Embryonic Stem Cells J Clin Med, 8(7).
PMID: 31277507
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

V Lungova et al. (2019), Human induced pluripotent stem cell-derived vocal fold mucosa mimics development and responses to smoke exposure Nat Commun, 10(1):4161.
PMID: 31551422
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

KB Jung et al. (2019), Blockade of STAT3 Causes Severe In Vitro and In Vivo Maturation Defects in Intestinal Organoids Derived from Human Embryonic Stem Cells J Clin Med, 8(7).
PMID: 31277507
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

K Shik Mun et al. (2019), Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders Nat Commun, 10(1):3124.
PMID: 31311920
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Zheng et al. (2019), Controlled modelling of human epiblast and amnion development using stem cells Nature, 573(7774):421-425.
PMID: 31511693
Species: Human
Sample Types: Whole Cells
Applications: Tissue Culture

R Sachdeva et al. (2019), BMP signaling mediates glioma stem cell quiescence and confers treatment resistance in glioblastoma Sci Rep, 9(1):14569.
PMID: 31602000
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Omi et al. (2019), Activin A receptor type 1-mediated BMP signaling regulates RANKL-induced osteoclastogenesis via canonical SMAD signaling pathway J. Biol. Chem., 0(0).
PMID: 31619522
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

J Piccand et al. (2019), Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells whileï¿½repressing genetic programs controllingï¿½serotonin production Mol Metab, 29(0):24-39.
PMID: 31668390
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

V Veschi et al. (2019), Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant Oncogene, 0(0).
PMID: 31591478
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

W Liang et al. (2019), Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells Stem Cells, 0(0).
PMID: 31648393
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Tripathi et al. (2019), Oligodendrocyte Intrinsic miR-27a Controls Myelination and Remyelination Cell Rep, 29(4):904-919.e9.
PMID: 31644912
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

T Yung et al. (2019), Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals Nat Commun, 10(1):4647.
PMID: 31604927
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Liu et al. (2019), Differential susceptibility of human neural progenitors and neurons to ischaemic injury Brain Res. Bull., 156(0):25-32.
PMID: 31837459
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

T Hyakumura et al. (2019), Organotypic Cocultures of Human Pluripotent Stem Cell Derived-Neurons with Mammalian Inner Ear Hair Cells and Cochlear Nucleus Slices Stem Cells Int, 2019(0):8419493.
PMID: 31827535
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

AP Marshall et al. (2019), Medial artery calcification increases neointimal hyperplasia after balloon injury Sci Rep, 9(1):8193.
PMID: 31160618
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

JE Ahlfors et al. (2019), Examining the fundamental biology of a novel population of directly reprogrammed human neural precursor cells Stem Cell Res Ther, 10(1):166.
PMID: 31196173
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

C Markouli et al. (2019), Gain of 20q11.21 in Human Pluripotent Stem Cells Impairs TGF-?-Dependent Neuroectodermal Commitment Stem Cell Reports, 13(1):163-176.
PMID: 31178415
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

KE Tumelty et al. (2018), Identification of direct negative crosstalk between the SLIT2 and Bone Morphogenetic Protein-Gremlin signaling pathways J. Biol. Chem., 0(0).
PMID: 29317497
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

S Chen et al. (2018), DEPTOR regulates osteogenic differentiation via inhibiting MEG3-mediated activation of BMP4 signaling and is involved in osteoporosis Stem Cell Res Ther, 9(1):185.
PMID: 29973283
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

M Amin et al. (2018), Cardiotrophic Growth Factor-Driven Induction of Human Muse Cells Into Cardiomyocyte-Like Phenotype Cell Transplant, 27(2):285-298.
PMID: 29637816
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

B Memon et al. (2018), Enhanced differentiation of human pluripotent stem cells into pancreatic progenitors co-expressing PDX1 and NKX6.1 Stem Cell Res Ther, 9(1):15.
PMID: 29361979
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

X Wang et al. (2018), Genome-wide analysis of PDX1 target genes in human pancreatic progenitors Mol Metab, 0(0).
PMID: 29396371
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MJ Workman et al. (2018), Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips Cell Mol Gastroenterol Hepatol, 5(4):669-677.e2.
PMID: 29930984
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

KKB Tan et al. (2018), Sequential Application of Discrete Topographical Patterns Enhances Derivation of Functional Mesencephalic Dopaminergic Neurons from Human Induced Pluripotent Stem Cells Sci Rep, 8(1):9567.
PMID: 29934644
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

GM D'Abaco et al. (2018), Graphene foam as a biocompatible scaffold for culturing human neurons R Soc Open Sci, 5(3):171364.
PMID: 29657752
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

F Zambelli et al. (2018), Random Mutagenesis, Clonal Events, and Embryonic or Somatic Origin Determine the mtDNA Variant Type and Load in Human Pluripotent Stemï¿½Cells Stem Cell Reports, 0(0).
PMID: 29910126
Species: Human

VM Jovanovic et al. (2018), BMP/SMAD pathway promotes neurogenesis of midbrain dopaminergic neurons in vivo and in human induced pluripotent and neural stem cells J. Neurosci., 0(0).
PMID: 29321139
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

I Espuny-Cam et al. (2018), Human Pluripotent Stem-Cell-Derived Cortical Neurons Integrate Functionally into the Lesioned Adult Murine Visual Cortex in an Area-Specific Way Cell Rep, 23(9):2732-2743.
PMID: 29847802
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

J Li et al. (2018), Decoding the dynamic DNA methylation and hydroxymethylation landscapes in endodermal lineage intermediates during pancreatic differentiation of hESC Nucleic Acids Res., 0(0).
PMID: 29394393
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Liu et al. (2018), Derivation of phenotypically diverse neural culture from hESC by combining adherent and dissociation methods J. Neurosci. Methods, 0(0).
PMID: 30003885
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Haider et al. (2018), Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta Stem Cell Reports, 0(0).
PMID: 30078556
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MA Scavuzzo et al. (2018), Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis Nat Commun, 9(1):3356.
PMID: 30135482
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

JD Blair et al. (2018), Genetically engineered human cortical spheroid models of tuberous sclerosis Nat. Med., 0(0).
PMID: 30127391
Species: Human
Sample Types: Organoids
Applications: Bioassay

R Cruz-Acuña et al. (2018), PEG-4MAL hydrogels for human organoid generation, culture, and in vivo delivery Nat Protoc, 0(0).
PMID: 30190557
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Zhang et al. (2018), 3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling Cell Stem Cell, 0(0).
PMID: 30244870
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

J Li et al. (2018), A transient DMSO treatment increases the differentiation potential of human pluripotent stem cells through the Rb family PLoS ONE, 13(12):e0208110.
PMID: 30540809
Species: Human
Sample Types: Organoids
Applications: Bioassay

C Bonamy et al. (2018), Expression of the human antimicrobial peptide ?-defensin-1 is repressed by the EGFR-ERK-MYC axis in colonic epithelial cells Sci Rep, 8(1):18043.
PMID: 30575780
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MA Scavuzzo et al. (2018), Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA Cell Rep, 25(13):3811-3827.e7.
PMID: 30590051
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

N Bayó-Puxan et al. (2018), Lysosomal and network alterations in human mucopolysaccharidosis type VII iPSC-derived neurons Sci Rep, 8(1):16644.
PMID: 30413728
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Michael J Workman et al. (2018), Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips. Cellular and Molecular Gastroenterology and Hepatology, 0(0):2352-345X.
PMID: 29930984
Species: Human
Sample Types: Organoids
Applications: Bioassay

E Sechet et al. (2018), Natural molecules induce and synergize to boost expression of the human antimicrobial peptide ?-defensin-3 Proc. Natl. Acad. Sci. U.S.A., 0(0).
PMID: 30275324
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Buskin et al. (2018), Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa Nat Commun, 9(1):4234.
PMID: 30315276
Species: Human
Sample Types: Organoid
Applications: Bioassay

EE Alexeev et al. (2018), Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor Am. J. Pathol., 0(0).
PMID: 29454749
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

SV Hegarty et al. (2017), Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation Sci Rep, 7(1):8568.
PMID: 28819210
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

JO Múnera et al. (2017), Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling Cell Stem Cell, 0(0).
PMID: 28648364
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

E Raja et al. (2017), Bone morphogenetic protein signaling mediated by ALK-2 and DLX2 regulates apoptosis in glioma-initiating cells Oncogene, 0(0).
PMID: 28459464
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Baronchell et al. (2017), Epigenetic and transcriptional modulation of WDR5, a chromatin remodeling protein, in Huntington's disease human induced pluripotent stem cell (hiPSC) model Mol. Cell. Neurosci., 82(0):46-57.
PMID: 28476540
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

N Avaliani et al. (2017), Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus Stem Cells Int, 2017(0):5718608.
PMID: 29317869
Species: Zebrafish
Sample Types: Whole Tissue
Applications: Bioassay

OH Ocaña et al. (2017), A right-handed signalling pathway drives heart looping in vertebrates Nature, 549(7670):86-90.
PMID: 28880281
Species: Primate
Sample Types: Whole Cells
Applications: Bioassay

T Yamashita et al. (2017), Differentiation of oligodendrocyte progenitor cells from dissociated monolayer and feeder-free cultured pluripotent stem cells PLoS ONE, 12(2):e0171947.
PMID: 28192470
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

J Drouin-Oue et al. (2017), REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways EMBO Mol Med, 9(8):1117-1131.
PMID: 28646119
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Shao et al. (2017), A pluripotent stem cell-based model for post-implantation human amniotic sac development Nat Commun, 8(1):208.
PMID: 28785084
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

T Ruetz et al. (2017), Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming Cell Stem Cell, 0(0).
PMID: 29174331
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

E Harper et al. (2017), TRAIL attenuates RANKL-mediated osteoblastic signalling in vascular cell mono-culture and co-culture models PLoS ONE, 12(11):e0188192.
PMID: 29145460
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

KF Cogger et al. (2017), Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors Nat Commun, 8(1):331.
PMID: 28835709
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

H Isshiki et al. (2017), Establishment of a refined culture method for rat colon organoids Biochem. Biophys. Res. Commun., 0(0).
PMID: 28559141
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

KW McCracken et al. (2017), Wnt/?-catenin promotes gastric fundus specification in mice and humans Nature, 0(0).
PMID: 28052057
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

M Bernhardt et al. (2017), Melanoma-Derived iPCCs Show Differential Tumorigenicity and Therapy Response Stem Cell Reports, 0(0).
PMID: 28392221
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

X Yuan et al. (2017), A hypomorphic PIGA gene mutation causes severe defects in neuron development and susceptibility to complement-mediated toxicity in a human iPSC model PLoS ONE, 12(4):e0174074.
PMID: 28441409
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

H Kilpinen et al. (2017), Common genetic variation drives molecular heterogeneity in human iPSCs Nature, 546(7658):370-375.
PMID: 28489815
Species: Human
Sample Types: Whole Cells
Applications: Differentiation

C Barry et al. (2017), Species-specific developmental timing is maintained by pluripotent stem cells ex utero Dev. Biol., 423(2):101-110.
PMID: 28179190
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay

(2016), Growth hormone is permissive for neoplastic colon growth Proc Natl Acad Sci USA, 0(0).
PMID: 27226307
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Jun Tao (2016), BMP4/Id2 signaling pathway is a novel therapeutic target for late outgrowth endothelial progenitor cell-mediated endothelial injury repair Int. J. Cardiol., 228(0):796-804.
PMID: 27888757
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016), Altered neuronal network and rescue in a human MECP2 duplication model Mol. Psychiatry, 21(2):178-88.
PMID: 26347316
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016), Reductive carboxylation is a major metabolic pathway in the retinal pigment epithelium Proc. Natl. Acad. Sci. U.S.A., 0(0).
PMID: 27911769
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Warren C Plaisted (2016), Remyelination Is Correlated with Regulatory T Cell Induction Following Human Embryoid Body-Derived Neural Precursor Cell Transplantation in a Viral Model of Multiple Sclerosis PLoS ONE, 11(6):e0157620.
PMID: 27310015
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Leslie J et al. (2015), Persistence and toxin production by Clostridium difficile within human intestinal organoids result in disruption of epithelial paracellular barrier function. Infect Immun, 83(1):138-45.
PMID: 25312952
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cebola I et al. (2015), TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors. Nat Cell Biol, 17(5):615-26.
PMID: 25915126
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pezzolla D et al. (2015), Resveratrol ameliorates the maturation process of beta-cell-like cells obtained from an optimized differentiation protocol of human embryonic stem cells. PLoS ONE, 10(3):e0119904.
PMID: 25774684
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Dye et al. (2015), In vitro generation of human pluripotent stem cell derived lung organoids. Elife, 4(0).
PMID: 25803487
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Huang S et al. (2015), The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells. Nat Protoc, 10(3):413-25.
PMID: 25654758
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hernanda P et al. (2015), SMAD4 exerts a tumor-promoting role in hepatocellular carcinoma. Oncogene, 34(39):5055-68.
PMID: 25531314
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

All A et al. (2015), Early intervention for spinal cord injury with human induced pluripotent stem cells oligodendrocyte progenitors. PLoS ONE, 10(1):e0116933.
PMID: 25635918
Species: Chicken
Sample Types: Whole Organism
Applications: In Vivo

Hu D et al. (2015), A dynamic Shh expression pattern, regulated by SHH and BMP signaling, coordinates fusion of primordia in the amniote face. Development, 142(3):567-74.
PMID: 25605783
Species: Chicken
Sample Types: Whole Tissue
Applications: Bioassay

Thiede B et al. (2014), Retinoic acid signalling regulates the development of tonotopically patterned hair cells in the chicken cochlea. Nat Commun, 5(0):3840.
PMID: 24845860
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wattanapanitch M et al. (2014), Dual small-molecule targeting of SMAD signaling stimulates human induced pluripotent stem cells toward neural lineages. PLoS ONE, 9(9):e106952.
PMID: 25207966
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cechin S et al. (2014), Influence of in vitro and in vivo oxygen modulation on beta cell differentiation from human embryonic stem cells. Stem Cells Transl Med, 3(3):277-89.
PMID: 24375542
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Burnight E et al. (2014), CEP290 gene transfer rescues Leber congenital amaurosis cellular phenotype. Gene Ther, 21(7):662-72.
PMID: 24807808
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

He Q et al. (2014), Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide. Mol Biol Cell, 25(11):1715-29.
PMID: 24694597
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Lee et al. (2014), Real-time discrimination between proliferation and neuronal and astroglial differentiation of human neural stem cells. Sci Rep, 4(0):6319.
PMID: 25204726
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pereira et al. (2014), Highly efficient generation of induced neurons from human fibroblasts that survive transplantation into the adult rat brain. Sci Rep, 4(0):6330.
PMID: 25208484
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Bayin et al. (2014), Selective lentiviral gene delivery to CD133-expressing human glioblastoma stem cells. PLoS ONE, 9(12):e116114.
PMID: 25541984
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Weedon M et al. (2014), Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis. Nat Genet, 46(1):61-4.
PMID: 24212882
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Dunworth et al. (2014), Bone morphogenetic protein 2 signaling negatively modulates lymphatic development in vertebrate embryos. Circ Res, 114(1):56-66.
PMID: 24122719
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Takeuchi et al. (2014), Endodermal differentiation of human pluripotent stem cells to insulin-producing cells in 3D culture. Sci Rep, 4(0):4488.
PMID: 24671046
Species: Chicken
Sample Types: Whole Cells
Applications: Bioassay

Mann Z et al. (2014), A gradient of Bmp7 specifies the tonotopic axis in the developing inner ear. Nat Commun, 5(0):3839.
PMID: 24845721
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ronaghi et al. (2014), Inner ear hair cell-like cells from human embryonic stem cells. Stem Cells Dev, 23(11):1275-84.
PMID: 24512547
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Lin P et al. (2014), A synthetic peptide-acrylate surface for production of insulin-producing cells from human embryonic stem cells. Stem Cells Dev, 23(4):372-9.
PMID: 24083371
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Lam A et al. (2014), Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers. J Am Soc Nephrol, 25(6):1211-25.
PMID: 24357672
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cai et al. (2014), Prospectively isolated NGN3-expressing progenitors from human embryonic stem cells give rise to pancreatic endocrine cells. Stem Cells Transl Med, 3(4):489-99.
PMID: 24493854
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Robson N et al. (2014), Optimal effector functions in human natural killer cells rely upon autocrine bone morphogenetic protein signaling. Cancer Res, 74(18):5019-31.
PMID: 25038228
Species: Mouse
Sample Types: Whole Organism
Applications: In Vivo

Zhang Y et al. (2014), Inhibition of bone morphogenic protein 4 restores endothelial function in db/db diabetic mice. Arterioscler Thromb Vasc Biol, 34(1):152-9.
PMID: 24202302
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pethe et al. (2014), Polycomb group protein expression during differentiation of human embryonic stem cells into pancreatic lineage in vitro. BMC Cell Biol, 15(0):18.
PMID: 24885493
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Lippmann E et al. (2014), Defined human pluripotent stem cell culture enables highly efficient neuroepithelium derivation without small molecule inhibitors. Stem Cells, 32(4):1032-42.
PMID: 24357014
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Farmer et al. (2013), Activation of the type I interferon pathway is enhanced in response to human neuronal differentiation. PLoS ONE, 8(3):e58813.
PMID: 23505563
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hannan et al. (2013), Generation of multipotent foregut stem cells from human pluripotent stem cells. Stem Cell Reports, 1(4):293-306.
PMID: 24319665
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tucker et al. (2013), Patient-specific iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa. Elife, 2(0):e00824.
PMID: 23991284
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Rezania A et al. (2013), Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo. Stem Cells, 31(11):2432-42.
PMID: 23897760
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Maroof A et al. (2013), Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells. Cell Stem Cell, 12(5):559-72.
PMID: 23642365
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Talavera-Adame et al. (2013), Bone morphogenetic protein-2/-4 upregulation promoted by endothelial cells in coculture enhances mouse embryoid body differentiation. Stem Cells Dev, 22(24):3252-60.
PMID: 23924071
Brafman D et al. (2013), Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions. Cell Death Differ, 20(3):369-81.
PMID: 23154389
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Buchholz et al. (2013), Rapid and efficient directed differentiation of human pluripotent stem cells into retinal pigmented epithelium. Stem Cells Transl Med, 2(5):384-93.
PMID: 23599499
Species: Xenopus
Sample Types: Whole Tissue
Applications: Bioassay

Swapna et al. (2012), Interplay between electrical activity and bone morphogenetic protein signaling regulates spinal neuron differentiation. Proc Natl Acad Sci U S A, 109(40):16336-41.
PMID: 22991474
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Li Q et al. (2012), Cited2 gene controls pluripotency and cardiomyocyte differentiation of murine embryonic stem cells through Oct4 gene. J Biol Chem, 287(34):29088-100.
PMID: 22761414
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Maegdefrau U et al. (2011), Downregulation of hemojuvelin prevents inhibitory effects of bone morphogenetic proteins on iron metabolism in hepatocellular carcinoma. Lab. Invest., 91(11):1615-23.
PMID: 21863061
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Spence JR et al. (2011), Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature, 470(7332):105-9.
PMID: 21151107
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Klim JR et al. (2010), A defined glycosaminoglycan-binding substratum for human pluripotent stem cells. Nat. Methods, 7(12):989-94.
PMID: 21076418
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Jiang J et al. (0), Translating dosage compensation to trisomy 21. Natur500(7462):296-300.
PMID: 23863942
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kumar Gupta A et al. (0), Asynchronous mixing of kidney progenitor cells potentiates nephrogenesis in organoids. Commun Bio3(1):231.
PMID: 32393756

There are no citations that match your criteria.

Showing 1 - 10 of 174 citations Showing All

Customer Reviews for Recombinant Human Noggin Protein (8)

4.5 out of 5

8 customer ratings

5 stars

50%

4 stars

50%

3 stars

2 stars

1 star

Customer Images

Showing 1 - 5 of 8 reviews Showing All

Filter By:

Recombinant Human Noggin Protein

Name: Anonymous

Application: Stem/Immune cell maintenance or differentiation

Verified Customer | Posted 09/26/2021

Used for iPSC differentiation into intestinal organoids at a concentration of 100ng/mL
Recombinant Human Noggin Protein

Name: Ermali Aliaj

Application: Cell Culture

Verified Customer | Posted 01/02/2021
Recombinant Human Noggin Protein

Name: Anonymous

Application: CellProlif

Reason for Rating: Cells grew well.

Verified Customer | Posted 12/28/2020
Recombinant Human Noggin Protein

Name: Anonymous

Application: Stem/Immune cell maintenance or differentiation

Verified Customer | Posted 04/05/2019
Recombinant Human Noggin Protein

Name: Anonymous

Application: Cell Culture

Verified Customer | Posted 12/22/2017

combination of a low dose of Noggin and the bone morphogenetic protein
Name: Anonymous

Verified Customer | Posted 04/25/2017
Recombinant Human Noggin Protein

Name: Anonymous

Application: Neural differentiation of iPSCs. Image is Nestin(Green), Sox1 (red) staining.

Verified Customer | Posted 01/04/2017
Recombinant Human Noggin Protein

Name: Anonymous

Verified Customer | Posted 10/26/2015

Noggin (100 ng/ml) was added into DMEM/F12 (plus B27 and N2) medium to promote neurogenesis of human-induced pluripotent stem cells.

There are no reviews that match your criteria.

Showing 1 - 5 of 8 reviews Showing All

FAQs for Recombinant Human Noggin Protein

What is the half life of Recombinant Human Noggin Protein (Catalog # 6057-NG) in vitro?

Recombinant Human Noggin Protein (Catalog # 6057-NG) is evaluated for bioactivity by its ability to inhibit BMP-4-induced alkaline phosphatase production in mouse chondrogenic cells in vitro. We have not evaluated the half-life of 6057-NG. The half-life of a specific protein will depend on experimental conditions, including the cell number, density, and media content. It is up to the end-users to determine the appropriate concentration and timing when adding 6057-NG to individual experiments. For techniques and methodologies, we recommend reviewing our list of publications under the Citations tab on the product-specific web page to find reported use of our products in similar experimental layouts.
Has Recombinant Human Noggin Protein (Catalog # 6057-NG or 6057-NG/CF) been evaluated in vivo?

Recombinant Human Noggin Protein (Catalog # 6057-NG) is evaluated for bioactivity by its ability to inhibit BMP-4-induced alkaline phosphatase production in mouse chondrogenic cells in vitro. We have not evaluated this protein for activity in vivo, but we are aware of publications citing use of the protein this type of experimentation. We recommend reviewing our list of publications under the Citations tab on the product-specific web page to find reported use of our products in similar experimental layouts.

Recombinant Human Noggin Protein

R&D Systems, Inc. a Bio-Techne Brand

Key Product Details

Customers also Viewed

Customers also Purchased

Product Specifications for Recombinant Human Noggin Protein

Scientific Data Examples for Recombinant Human Noggin Protein

Formulation, Preparation and Storage

Carrier Free

6057-NG

Carrier

6057-NG/CF

Carrier Free

Reconstitution Calculator

Background: Noggin

Citations for Recombinant Human Noggin Protein (174)

Customer Reviews for Recombinant Human Noggin Protein (8)

Customer Images

Recombinant Human Noggin Protein

Recombinant Human Noggin Protein

Recombinant Human Noggin Protein

Recombinant Human Noggin Protein

Recombinant Human Noggin Protein

Recombinant Human Noggin Protein

Recombinant Human Noggin Protein

FAQs for Recombinant Human Noggin Protein

Product Documents for Recombinant Human Noggin Protein

Product Datasheets

COA

Certificate of Analysis

SDS

Bio-Techne Brands

Stay Connected